Collagen mineralization: Aspects of the structural relationship between collagen and the apatitic crystallites

Höhling, H. J.; Barckhaus, R.H.; Krefting, E. R.; Althoff, J.; Quint, P.

doi:10.1007/978-1-4613-1487-5_3

Cited by 33 publications

(21 citation statements)

References 32 publications

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“…Besides this assumption it has also been concluded, since several years, that the primary crystal formations in the collagen-rich hard tissues are needles (rods; Boyde 1974;Hayashi 1984;Bonucci 1985;Katz et al 1989;Weiner et al 1991;Fratzl et al 1992;Traub et al 1992). Höhling et al (1970Höhling et al ( , 1971aHöhling et al ( ,b, 1981Höhling et al ( , 1990) have come to the conclusion that in developing dentine, enamel, bone, growth plate cartilage, and physiologically mineralising turkey tibia tendon, the primary crystal formations are thin Ca-phosphate chains, apatitic strands, composed of nanometer-sized particles. Their centre-to-centre distances represent the distances between nucleating sites, called active sites, along the matrix macromolecules.…”

Section: Introductionmentioning

confidence: 92%

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Quantitative electron-spectroscopic diffraction (ESD) and electron-spectroscopic imaging (ESI) analyses of dentine mineralisation in rat incisors

Arnold

Plate

Wiesmann

et al. 1997

Cell and Tissue Research

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Primary crystal formations in all hard tissues are, according to our investigations, Ca-phosphate chains composed of nanometer sized particles (dots) which develop along the matrix macromolecules. In circumpulpal dentine the centre-to-centre distances between the dots inside the chains reflect the distances between the crystal nucleating sites ("active sites") along the collagen matrix macromolecule. The centre-to-centre distances at the surface of the mineralised collagen fibrils probably reflect the distances between nucleating sites of noncollagenous proteins attached to collagen. These needle-like chains of dots coalesce in lateral directions to form ribbon-like crystallites. The morphological results are supported by correlated small area diffraction studies in the same regions of dentine. We have found that the first appearing Bragg-reflection has a lattice spacing value of 0.388 nm, which corresponds to the (111) apatite value. For the earliest crystal formations the intensity of the (002) reflection is higher than that of the (300)-reflection. A maximum of the net-signal-intensity ratio of the (002) to (300) Bragg-reflection appears at the mineralisation front. This peak repeats with decreasing height 3 to 5 times with a distance range of about 8-16 microm through the whole dentine zone, which corresponds to the distances of the incremental lines, called "von Ebner lines".

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Section: Introductionmentioning

confidence: 92%

“…Höhling et al 1971aHöhling et al ,b, 1980Höhling et al , 1990Höhling et al , 1995Plate et al 1992), the collagen macroperiod, i.e. the hole and overlapping zone, is often not reinforced by the mineralisation process of the singly lying collagen fibrils in the circumpulpal dentine.…”

Section: Analyses Of the Nanometer-sized Particles In The Apatitic Chmentioning

confidence: 99%

Quantitative electron-spectroscopic diffraction (ESD) and electron-spectroscopic imaging (ESI) analyses of dentine mineralisation in rat incisors

Arnold

Plate

Wiesmann

et al. 1997

Cell and Tissue Research

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“…In special cases, limited data are available on the microstructure of the healing tissue at the implant interface at an ultrastructural and crystallographic level 102 . In addition, the complex interactions of cells and extracellular matrix components with mineral deposits directly after insertion and under immediate mechanical loads are poorly understood 44,45 . Various analytical methods nowadays allow a more precise insight into bone mineralization.…”

Section: Influence Of Bone Biology On Osseointegrationmentioning

confidence: 99%

Mineralization at the interface of implants

Joos¹,

Wiesmann²,

Szuwart³

et al. 2006

International Journal of Oral and Maxillofacial Surgery

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“…In bone and other hard tissues, collagen is the main component of the organic phase and, therefore, the configuration and arrangement of the collagen fibrils are thought to be the most important factors in the regulation of size and location of the apatite crystallites (Höhling 1990 et al;Glimcher 1992). Transmission electron-microscopic images of the mineral-matrix complex are not easily interpreted due to the two-dimensional projection of the mineral phase.…”

Section: Introductionmentioning

confidence: 99%

Sutural mineralization of rat calvaria characterized by atomic-force microscopy and transmission electron microscopy

Wiesmann

Chi

Stratmann

et al. 1998

Cell and Tissue Research

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The application of transmission electron microscopy (TEM) and atomic-force microscopy (AFM) aid the acquisition of detailed structural information on the process of hard tissue formation. The sutural mineralization of rat calvaria is taken as a model for a collagen-related mineralization system. After cryofixation or chemical fixation an anhydrous tissue preparation technique with no staining procedures is used. The atomic-force microscope and the transmission electron microscope are used for structural analysis of the mineralizing region of the sutural tissue. With the application of AFM the collagen macroperiod is shown to be well represented in the unmineralized sutural tissue. At the mineralization front the collagen fibrils are found to be thickened and to change to a characteristic stacked platelet structure. Using TEM the macroperiod is faintly visible before mineral crystallites have formed and is more prominent after the apatite crystallization has started in the fibrils. In this step a needle-like structure of the newly formed apatitic crystals is visible.

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Collagen mineralization: Aspects of the structural relationship between collagen and the apatitic crystallites

Cited by 33 publications

References 32 publications

Quantitative electron-spectroscopic diffraction (ESD) and electron-spectroscopic imaging (ESI) analyses of dentine mineralisation in rat incisors

Quantitative electron-spectroscopic diffraction (ESD) and electron-spectroscopic imaging (ESI) analyses of dentine mineralisation in rat incisors

Mineralization at the interface of implants

Sutural mineralization of rat calvaria characterized by atomic-force microscopy and transmission electron microscopy

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