Collagen peptide from Walleye pollock skin attenuated obesity and modulated gut microbiota in high-fat diet-fed mice

Wang, Shuo; Lv, Zhiyuan; Zhao, Wandong; Wang, Linna; He, Ningning

doi:10.1016/j.jff.2020.104194

Cited by 32 publications

(28 citation statements)

References 60 publications

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“…As a result of these beneficial health effects, people have been motivated to consume a diet rich in collagen peptides in some areas of the world, such as China. Collagen peptide derived from walleye pollock skin was reported to suppress obesity via modulating gut microbiota in high-fat diet-fed mice [ 55 ]. The feeding enhanced the beneficial bacterial count relative to Lactobacillus, Akkermansia muciniphila, Parabacteroides , and Odoribacter spp while, the intervention reduced the number of intestinal inflammation bacteria, such as Erysipelatoclostridium and Alistipes [ 55 ].…”

Section: Gut Microbiota Obesity and Hydrolysates/bioactive Peptidesmentioning

confidence: 99%

“…Collagen peptide derived from walleye pollock skin was reported to suppress obesity via modulating gut microbiota in high-fat diet-fed mice [ 55 ]. The feeding enhanced the beneficial bacterial count relative to Lactobacillus, Akkermansia muciniphila, Parabacteroides , and Odoribacter spp while, the intervention reduced the number of intestinal inflammation bacteria, such as Erysipelatoclostridium and Alistipes [ 55 ]. Akkermansia muciniphila is well-known for its anti-obesity effects and is also positively correlated with glucose tolerance while Lactobacillus is a typical beneficial bacterium in obesity, with studies indicating that the bacterium ameliorates high fat-fed diet-induced blood glucose intolerance and adipose tissue accumulation [ 56 , 57 ].…”

Section: Gut Microbiota Obesity and Hydrolysates/bioactive Peptidesmentioning

confidence: 99%

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The Functional Interplay between Gut Microbiota, Protein Hydrolysates/Bioactive Peptides, and Obesity: A Critical Review on the Study Advances

Aloo

2022

Antioxidants

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Diet is an essential factor determining the ratio of pathogenic and beneficial gut microbiota. Hydrolysates and bioactive peptides have been described as crucial ingredients from food protein that potentially impact human health beyond their roles as nutrients. These compounds can exert benefits in the body, including modulation of the gut microbiota, and thus, they can reduce metabolic disorders. This review summarized studies on the interaction between hydrolysates/peptides, gut microbes, and obesity, focusing on how hydrolysates/peptides influence gut microbiota composition and function that improve body weight. Findings revealed that gut microbes could exert anti-obesity effects by controlling the host’s energy balance and food intake. They also exhibit activity against obesity-induced inflammation by changing the expression of inflammatory-related transcription factors. Protein hydrolysates/peptides can suppress the growth of pro-obesity gut bacteria but facilitate the proliferation of those with anti-obesity effects. The compounds provide growth factors to the beneficial gut bacteria and also improve their resistance against extreme pH. Hydrolysates/peptides are good candidates to target obesity and obesity-related complications. Thus, they can allow the development of novel strategies to fight incidences of obesity. Future studies are needed to understand absorption fate, utilization by gut microbes, and stability of hydrolysates/peptides in the gut under obesity.

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Section: Gut Microbiota Obesity and Hydrolysates/bioactive Peptidesmentioning

confidence: 99%

Section: Gut Microbiota Obesity and Hydrolysates/bioactive Peptidesmentioning

confidence: 99%

The Functional Interplay between Gut Microbiota, Protein Hydrolysates/Bioactive Peptides, and Obesity: A Critical Review on the Study Advances

Aloo

2022

Antioxidants

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“…Recently, it was reported that walleye pollock skin collagenderived peptides considerably reduced the BW gain in obese mice after 8 weeks of peptide treatment [58]. The authors also pointed that peptides inhibited the growth of adipocytes and the accumulation of adipose tissue in obese mice.…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 96%

“…It was demonstrated that Spirulina platensis -derived peptides exhibited antiobesity effects by reducing BW (39.8%) and lowering serum glucose (23.8%) through altering the gene expressions of Acadm, Retn, Fabp4, Ppard, and Slc27a1 in the brain and liver of mice fed with peptides (2 g/kg BW) for 4 weeks [ 57 ]. Recently, it was reported that walleye pollock skin collagen-derived peptides considerably reduced the BW gain in obese mice after 8 weeks of peptide treatment [ 58 ]. The authors also pointed that peptides inhibited the growth of adipocytes and the accumulation of adipose tissue in obese mice.…”

Section: Role Of Dietary Bioactive Peptides In Obesitymentioning

confidence: 99%

Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders

Qiao

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Bioactive peptides (BPs) are fragments of 2–15 amino acid residues with biological properties. Dietary BPs derived from milk, egg, fish, soybean, corn, rice, quinoa, wheat, oat, potato, common bean, spirulina, and mussel are reported to possess beneficial effects on redox balance and metabolic disorders (obesity, diabetes, hypertension, and inflammatory bowel diseases (IBD)). Peptide length, sequence, and composition significantly affected the bioactive properties of dietary BPs. Numerous studies have demonstrated that various dietary protein-derived BPs exhibited biological activities through the modulation of various molecular mechanisms and signaling pathways, including Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element in oxidative stress; peroxisome proliferator-activated-γ, CCAAT/enhancer-binding protein-α, and sterol regulatory element binding protein 1 in obesity; insulin receptor substrate-1/phosphatidylinositol 3-kinase/protein kinase B and AMP-activated protein kinase in diabetes; angiotensin-converting enzyme inhibition in hypertension; and mitogen-activated protein kinase and nuclear factor-kappa B in IBD. This review focuses on the action of molecular mechanisms of dietary BPs and provides novel insights in the maintenance of redox balance and metabolic diseases of human.

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“…The reduction of plasma LDL, TG levels and relative abundance of Erysipelotrichaceae observed in the present study supports the association between Erysipelotrichaceae and host lipid metabolism. At the genus level, abundance of Blautia, Clostridium sensu stricto 1, intestinal inflammation bacteria Erysipelatoclostridium [48], Romboutsia and Turicibacter genera was significantly decreased by HFB diet compared to HF diet, where Blautia was inversely correlated with visceral fat [49].…”

Section: Gut Microbiome Analysismentioning

confidence: 97%

Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets

Tan

Tam

Meng

et al. 2021

Foods

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Colored common beans are associated with health promoting and chronic disease prevention effects. Male C57BL/6J mice were fed high-fat (HF) diets supplemented with cooked black turtle beans (HFB) to prevent obesity related insulin resistance. Mice on both HF and HFB were obese compared to mice fed a low-fat (LF) diet. Plasma low density lipoprotein (LDL) and triglyceride concentrations of mice fed HFB diet were 28% and 36.6% lower than those on HF diet. Homeostatic model assessment of insulin resistance (HOMA-IR) index of mice fed HFB diet was 87% lower than that of mice fed HF diet. Diabetes related biomarkers, gastric inhibitory polypeptide (GIP), leptin, glucagon, and inflammatory cytokines interleukin 4 (IL-4) and IL-5, 10 and 12, IFN-g and TNF-α were significantly affected by HFB diet. Pparα, Cyp7a1 and Fasn were down-regulated by HFB diet while LDL-R, Srebp-2, Adipoq and Slc2a4 were up-regulated by HFB diet. The ratio of Firmicutes/Bacteroidetes (F/B) was also decreased 64.1% by HFB diet compared to HF diet. The results indicated that cooked black turtle bean consumption could ameliorate insulin resistance and lower plasma LDL in mice fed HF diet through glucose signaling pathway and JNK/c-Jun pathway. Meanwhile, cooked black turtle bean consumption restored the gut microbiome.

show abstract

Collagen peptide from Walleye pollock skin attenuated obesity and modulated gut microbiota in high-fat diet-fed mice

Cited by 32 publications

References 60 publications

The Functional Interplay between Gut Microbiota, Protein Hydrolysates/Bioactive Peptides, and Obesity: A Critical Review on the Study Advances

The Functional Interplay between Gut Microbiota, Protein Hydrolysates/Bioactive Peptides, and Obesity: A Critical Review on the Study Advances

Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders

Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets

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