Collagen/Povidone as a New Endoscopic Treatment Option in Peptic Ulcer Bleeding

Hoyos, Alberto de; Monroy, Manuel; Checa, Giancarlo; Rodríguez, Pablo Fernández

doi:10.1055/s-2005-870209

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The amount of solution was chosen empirically and was injected only in and around the lesion and sprayed over the surface of the ulcer. This decision was supported by previous reports of cases in which collagen-PVP treatment was successfully used (injecting intramuscularly and subcutaneously for patients with rheumatoid arthritis and scleroderma, and application to the surface of dermatological ulcers secondary to venous insufficiency [4][5][6], as well as in the case described in our previous publication [3]). The patient consented to the use of the biological compound for treatment.…”

Section: Case Presentationmentioning

confidence: 58%

“…It also modulates collagen turnover by decreasing collagenolytic activity and tissue inhibitor of metalloproteinase-1 production and increasing the amount of type III collagen. This is possibly accomplished by downregulating proinflamamatory cytokines and adhesion molecules such as intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin-1beta, tumour necrosis factor-alpha and platelet-derived growth factor (3,(7)(8)(9)(10). Intralesional injection of collagen-PVP once a week for one to three months into human hypertrophic scars or scleroderma lesions diminishes pruritus, pain, erythema, volume and inflammatory infiltrates (5,11).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ileocolonic Ulcer Treated by Endoscopic Application of Collagen-Polyvinylpyrrolidone

Garza

Aguilar

Richards

2007

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

A de Hoyos Garza, EA Esparza Aguilar, G Checa Richards. Ileocolonic ulcer treated by endoscopic application of collagenpolyvinylpyrrolidone. Can J Gastroenterol 2007;21(8):513-515.Ulceration is a complication that may occur after an ileocolonic anastomosis. Most of the etiologies remain speculative. The case of a 33-year-old woman with eosinophilic colitis is reported, in whom a colectomy with an ileocolonic anastomosis was performed. After four months, the patient presented with a stenosis in the ileocolonic anastomosis, necessitating surgical restoration. Four weeks later, the patient presented with rectal bleeding, and a colonoscopy showed an ulcer in the anastomosis. Collagenpolyvinylpyrrolidone was applied into and on the surface of the ulcer, and five days later the procedure was repeated. Follow-up endoscopies at seven days and three months showed complete healing of the ulcer and the patient remained without bleeding throughout a further four weeks of follow-up tests. It was concluded that this biological product could be an excellent treatment for these lesions.Key Words: Collagen-polyvinylpyrrolidone; Ileocolonic ulcer; Ulcer healing Un ulcère iléocolique traité par application endoscopique de collagène polyvinyle pyrolidone L'ulcération est une complication qui peut se produire après une anastomose iléocolique. La plupart des étiologies demeurent spéculatives. On présente le cas d'une femme de 33 ans atteinte de colite éosinophile dans le présent article, chez qui on a procédé à une colectomie avec anastomose iléocolique. Au bout de quatre mois, la patiente souffrait d'une sténose de l'anastomose iléocolique, exigeant une restauration chirurgicale. Quatre semaines plus tard, la patiente a consulté pour des saignements rectaux, et une coloscopie a révélé un ulcère de l'anastomose. On a appliqué du collagène polyvinyle pyrolidone à la surface de l'ulcère et dans celui-ci et on a repris l'intervention cinq jours plus tard. Des endoscopies de suivi au bout de sept jours et de trois mois ont révélé une cicatrisation complète de l'ulcère, et la patiente n'a présenté aucun saignement pendant les quatre autres semaines de tests de suivi. On a conclu que ce produit biologique peut constituer un excellent traitement pour ces lésions.

show abstract

Section: Case Presentationmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Ileocolonic Ulcer Treated by Endoscopic Application of Collagen-Polyvinylpyrrolidone

Garza

Aguilar

Richards

2007

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…The physicochemical and pharmacological properties of this copolymer are derived from its components. C–PVP exhibits immunomodulatory and tissue-regenerative properties, which have been evidenced in different pathologies in acute and chronic stages in various fields, including orthopedics and trauma, − vascular surgery, gynecology and gastroenterology, − as well as dermatology and rheumatology. − …”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Functional Characterization of the Collagen–Polyvinylpyrrolidone Copolymer

et al. 2014

View full text Add to dashboard Cite

Collagen-polyvinylpyrrolidone (C-PVP) is a copolymer that is generated from the γ irradiation of a mixture of type I collagen and low-molecular-weight PVP. It is characterized by immunomodulatory, fibrolytic, and antifibrotic properties. Here, we used various physicochemical and biological strategies to characterize the structure, biochemical susceptibility, as well as its effects on metabolic activity in fibroblasts. C-PVP contained 16 times more PVP than collagen, but only 55.8% of PVP was bonded. Nevertheless, the remaining PVP exerted strong structural activity due to the existence of weak bonds that provided shielding in the NMR spectra. On SEM and AFM, freeze-dried C-PVP appeared as a film that uniformly covered the collagen fibers. Size analysis revealed the presence of abundant PVP molecules in the solution of the copolymer with a unique dimension related to macromolecular combinations. Calorimetric analysis showed that the copolymer in solution exhibited structural changes at 110 °C, whereas the lyophilized form showed such changes at temperatures below 50 °C. The copolymer presented a rheopectic behavior, with a predominant effect of the collagen. C-PVP had biological effects on the expression of integrin α2 and prolyl-hydroxylase but did not interact with cells through the collagen receptors because it did not inhibit or slow contraction.

show abstract

Collagen/Povidone as a New Endoscopic Treatment Option in Peptic Ulcer Bleeding

Cited by 2 publications

References 0 publications

Ileocolonic Ulcer Treated by Endoscopic Application of Collagen-Polyvinylpyrrolidone

Ileocolonic Ulcer Treated by Endoscopic Application of Collagen-Polyvinylpyrrolidone

Physicochemical and Functional Characterization of the Collagen–Polyvinylpyrrolidone Copolymer

Contact Info

Product

Resources

About