Collagen Production and Types in Fibrous Capsules Around Breast Implants

Bj, McCoy; Person, Philip; Ik, Cohen

doi:10.1097/00006534-198406000-00012

Cited by 25 publications

(16 citation statements)

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“…Also as noted above, in vitro studies have shown that IFN-'y down-regulates collagen and fibronectin synthesis (16)(17)(18) and this decreased synthesis is associated with decreased levels of mRNA (19)(20)(21). Fibrous capsule formation around alloplastic implants in humans and animals, including breast implants (38,39), silicone plates (40), Marlex mesh (41), and nylon velour pouches (42) has been observed previously. Our finding that a similar phenomenon occurs with the osmotic pumps allowed us to develop an in vivo model for soluble mediator effects on new collagen synthesis.…”

Section: Discussionmentioning

confidence: 68%

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

Granstein¹,

Murphy²,

Margolis³

et al. 1987

J. Clin. Invest.

166

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Subcutaneous implantation of osmotic pumps into CAF1 mice resulted in the formation of thick fibrous capsules around the pumps. When pumps were loaded with recombinant murine gamma-interferon (rMuIFN-'y) to deliver 2 X 103 U/h for 14 d, there was a marked decrease in thickness and collagen content of the capsules from rMuIFN-'y-treated animals compared with capsules from animals receiving diluent alone. The collagen content of the capsules was estimated by hydroxyproline analysis of the tissue and by quantitative electron microscopy of collagen bundles. Heat-inactivated rMuIFN-'y failed to reduce the fibrotic response in this assay. These results provide compelling evidence that gamma-interferon can down-regulate collagen synthesis in vivo and suggest the possibility that this lymphokine may be useful in the treatment of disease states characterized by excessive fibrosis.

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Section: Discussionmentioning

confidence: 68%

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

Granstein¹,

Murphy²,

Margolis³

et al. 1987

J. Clin. Invest.

166

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show abstract

“…Collagen type III, which is encoded for by the COL3A1 gene on chromosome 2q31, is one of the fibril-forming collagens. Previous studies of collagen type III in breast capsules showed no significant correlation with severity of contracture [20,21] . However, the proportion of collagen type III:type I is known to de- crease during the proliferation and maturation stages of wound healing [22] .…”

Section: Discussionmentioning

confidence: 67%

Tumour Necrosis Factor-α Expression Is Associated with Increased Severity of Periprosthetic Breast Capsular Contracture

et al. 2010

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Background: The pathogenesis of periprosthetic capsular contracture following breast implant surgery is unclear. The aim of this study was to identify the expression of tumour necrosis factor-α (TNF-α), collagen type III α₁ (COL3A1), transforming growth factor-β₁ (TGF-β₁) and connective tissue growth factor (CTGF) in different Baker grades of breast capsular contracture. Methods: Seven periprosthetic breast capsule specimens were collected from 6 patients. TNF-α, COL3A1, TGF-β₁ and CTGF gene expression were analysed using real-time quantitative polymerase chain reaction. Immunohistolocalisation of TNF-α was performed on paraffin-embedded sections. Significant correlations were analysed using the Pearson correlation coefficient. Results: TNF-α expression was associated with increased Baker grade of capsular contracture (Pearson correlation, r = 0.558; p = 0.02). COL3A1 gene expression was reduced with increasing severity of contracture (r = –0.490; p = 0.05). There were no significant correlations between TGF-β₁ and CTGF expression with Baker grade. Positive TNF-α staining in breast capsules was localised to fibroblasts, macrophages, and extracellularly close to the prosthesis. Conclusion: The increased expression of TNF-α may play a key role in the inflammatory response associated with capsular contracture. The corresponding decrease in COL3A1 may contribute to the change in capsular physical properties seen in capsular contracture.

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“…In patient populations, this condition is accompanied by overt symptoms and loss of esthetic results of breast augmentation 13 Since the first reports on capsular contracture in the literature, a number of preclinical studies have been conducted in an attempt to prevent its development, using different drugs (such as leukotriene receptor antagonists, antibiotics, anti-neoplastic and antifibroticagents, steroids and non-steroidal anti-inflammatory drugs) administered locally or systemically, but with disappointing results [3][4][5][6][7][8][9][13][14][15][16] . Thus, there is currently no proven pharmacological therapy for ACC 13 .…”

Section: Discussionmentioning

confidence: 99%

“…Long time ago it was hypothesized that collagen production and deposition might be increased by inflammation in contracted capsules since there is histological evidence for increased lymphocytes, macrophages and multinuclear giant cells [6][7][8][12][13][14] . Also, the ratio of collagen type I:type III increases in rigid tissue compared with more distensible ones 15 . The management of ACC is a wellknown problem for plastic surgeons.…”

Section: Introductionmentioning

confidence: 99%

“…The management of ACC is a wellknown problem for plastic surgeons. ACC occurs in 0-74% of breast implant operations depending on the series, follow-up, implant shell and content, surface texture, presence of subclinical infection or accumulation of tissue fluids in the implant pocket, patient age, surgical technique and anatomical location of implants and others [9][10][11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of propranolol on capsular reaction around silicone implants in guinea pigs

Mesquita

Guimarães²,

Filho³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model. METHODS:Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation). RESULTS:Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant. CONCLUSION:Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.

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Collagen Production and Types in Fibrous Capsules Around Breast Implants

Cited by 25 publications

References 0 publications

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

Gamma-interferon inhibits collagen synthesis in vivo in the mouse.

Tumour Necrosis Factor-α Expression Is Associated with Increased Severity of Periprosthetic Breast Capsular Contracture

Effect of propranolol on capsular reaction around silicone implants in guinea pigs

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