Collagen-silica nanocomposites as dermal dressings preventing infection in vivo

Mebert, Andrea Mathilde; Álvarez, Gisela Solange; Peroni, Roxana N.; Illoul, Corinne; Hélary, Christophe; Coradin, Thibaud; Desimone, Martín Federico

doi:10.1016/j.msec.2018.07.078

Cited by 43 publications

(26 citation statements)

References 23 publications

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“…The by‐products or metabolites that have an acidic and/or alkaline character could alter the stability of the 3D matrix by influencing on its performance. On the other hand, hydrogels must also show biodegradation evaluated by the effect of proteolytic enzymes, which allows the formation of new tissue without deformation or scarring, since the new tissue is formed as the hydrogel is biodegraded 36,37 . Controlled swelling and diffusion also depend on pH and are parameters that should be considered when bioactive molecules or cells are encapsulated within hydrogels ensuring their controlled and sustained release 35,38 .…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, hydrogels must also show biodegradation evaluated by the effect of proteolytic enzymes, which allows the formation of new tissue without deformation or scarring, since the new tissue is formed as the hydrogel is biodegraded. 36,37 Controlled swelling and diffusion also depend on pH and are parameters that should be considered when bioactive molecules or cells are encapsulated within hydrogels ensuring their controlled and sustained release. 35,38 With this in mind, the results of the evaluation of the degradation and swelling behavior indicates that these novel semi-IPN matrices show control in these properties, which would increase their applicability in biomedical areas.…”

Section: Swelling/degradation Behavior Of Hydrogelsmentioning

confidence: 99%

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Novel semi‐interpenetrated networks based on collagen‐polyurethane‐polysaccharides in hydrogel state for biomedical applications

Claudio‐Rizo

Hernandez‐Hernandez

Cano-Salazar

et al. 2020

J of Applied Polymer Sci

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The development of collagen hydrogels with tailored properties for improved applications in biomedicine represents an area of opportunity for materials science. The collagen can form semi-interpenetrated networks (semi-IPN) with various natural and/or synthetic polymers. This work aims the preparation of novel hydrogels generated from a collagen matrix cross-linked with polyurethane (PU), and the subsequent inclusion of polysaccharide chains to form semi-IPN systems with improved properties. The choice of polysaccharides for this purpose is related to their ability to modulate the biocompatibility and the antibacterial capacity in various biomedical strategies. The work

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Section: Resultsmentioning

confidence: 99%

Section: Swelling/degradation Behavior Of Hydrogelsmentioning

confidence: 99%

Novel semi‐interpenetrated networks based on collagen‐polyurethane‐polysaccharides in hydrogel state for biomedical applications

Claudio‐Rizo

Hernandez‐Hernandez

Cano-Salazar

et al. 2020

J of Applied Polymer Sci

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“…The sutures were first stretched twofold of their initial length and maintained for 10 min at 50°C, then cooled at room temperature and kept in ambient temperature before use. The mouse skin suture-wound model was established as described previously, with minor modifications (Mebert et al, 2018). Briefly, the mice were anesthetized with intraperitoneal administration of pentobarbital sodium (3% in saline solution) at a dose of 1 ml/ kg.…”

Section: Mouse Skin Suture-wound Modelmentioning

confidence: 99%

Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture

et al. 2020

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The surgical suture has long been used to reconnect the injured tissues to restore their structure and function. However, its utility remains challenging in many areas, such as surgical site infections and minimally invasive surgeries. Herein, we report a novel surgical suture that possesses both antibacterial activity and shape memory effect to address these issues. In detail, natural antibacterial berberine was incorporated directly into the spinning solution of shape memory polyurethane with a near body transition temperature, and then berberine-containing polyurethane (BP) fibers were prepared by a facile one-step wetspinning method for surgical suture. The prepared BP fibers were micro-sized and characterized by their transition temperature, morphology, water contact angles, mechanical properties, in vitro shape memory effect, drug release, and antibacterial activity. The results showed that with the increasing amount of the incorporated berberine, the transition temperatures of the fibers were not significantly affected, remains at near body temperature, while the contact angles of the fibers were significantly decreased and the mechanical properties of the fibers were significantly weakened. The optimized fiber was selected to evaluate the cytotoxicity and in vivo biocompatibility before in vivo shape memory effect and wound healing capacity in a mouse skin suture-wound model was tested. Besides the shape memory effect, it was demonstrated that the fiber is capable of antibacterial activity and anti-inflammatory effect, and promoting wound healing. The mechanism of the antibacterial activity and anti-inflammatory effect of the fiber was discussed. Overall, it is expected that by the berberine added to the fiber for surgical suture, it will be more popular and extend the utility of the sutures in a wide range of clinical applications.

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“…Over the last years, collagen has gained widespread popularity as scaffolds for wound healing and drug delivery 13,14 . Collagen is the most abundant protein in vivo and is the major responsible for maintaining the biological and structural integrity of the extracellular matrix 15 .…”

Section: Introductionmentioning

confidence: 99%

Tuning the antimicrobial activity of collagen biomaterials through a liposomal approach

Municoy

Antezana

Pérez

et al. 2020

J of Applied Polymer Sci

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The development of advanced biocidal agents stands as a global challenge, focused on the increasing demand of new biomaterials with local and gradual release of antimicrobial agents. This is the first time that three well‐known materials are strategically combined to develop a novel biomaterial with long‐term bactericidal activity that avoids burst release and toxic effects, by the incorporation of silver nanoparticles in liposomes and the subsequent incorporation of these assemblies in collagen hydrogels. These systems show improved mechanical properties and prolonged inhibitory effect on the growth of Gram‐positive (Staphylococcus aureus) and Gram‐negative (Pseudomonas aeruginosa) bacteria, while remaining highly biocompatible for epithelial cells. In fact, the hybrid biocomposite prevents bacterial colonization for at least 72 h, allowing at the same time eukaryotic cell proliferation. As a result, this new bactericidal biomaterial provides a new alternative to improve current treatments of bacterial infections with many implications in significant applications, such as wound therapy and tissue regeneration.

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Collagen-silica nanocomposites as dermal dressings preventing infection in vivo

Cited by 43 publications

References 23 publications

Novel semi‐interpenetrated networks based on collagen‐polyurethane‐polysaccharides in hydrogel state for biomedical applications

Novel semi‐interpenetrated networks based on collagen‐polyurethane‐polysaccharides in hydrogel state for biomedical applications

Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture

Tuning the antimicrobial activity of collagen biomaterials through a liposomal approach

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