Collagen synthesis-promoting and collagenase inhibitory activities of constituents isolated from the rhizomes of Picrorhiza kurroa Royle ex Benth

Morikawa, Toshio; Inoue, N.; Nakanishi, Yusuke; Manse, Yoshiaki; Matsuura, Hideyuki; Okino, Kenji; Hamasaki, Shinya; Yoshikawa, Masayuki; Muraoka, Osamu; Ninomiya, Kiyofumi

doi:10.1016/j.fitote.2020.104584

Cited by 18 publications

(15 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, it was reported that calceolarioside A induced moderate antibacterial activity against Bacillus cereus NRRLB 3711 [ 16 ], antifungal activity against Malassenzia spp. [ 17 ], and collagenase inhibitory activity [ 18 ] and putative anti-viral activity against COVID-19 from docking and molecular dynamics simulation data [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties

et al. 2022

View full text Add to dashboard Cite

Phenylpropanoid glycosides are a class of natural substances of plant origin with interesting biological activities and pharmacological properties. This study reports the antinociceptive and anti-inflammatory effects of calceolarioside A, a phenylpropanoid glycoside previously isolated from various Calceolaria species. In models of acute nociception induced by thermal stimuli, such as the hot plate and tail flick test, calceolarioside administered at doses of 1, 5, and 10 μg in the left cerebral ventricles did not modify the behavioral response of mice. In an inflammatory based persistent pain model as the formalin test, calceolarioside A at the high dose tested (100 μg/paw) reduced the licking activity induced by formalin by 35% in the first phase and by 75% in the second phase of the test. In carrageenan-induced thermal hyperalgesia, calceolarioside A (50 and 100 μg/paw) was able to significantly reverse thermal hyperalgesia induced by carrageenan. The anti-inflammatory activity of calceolarioside A was then assessed using the zymosan-induced paw edema model. Calceolarioside A (50 and 100 μg/paw) induced a significant reduction in the edema from 1 to 4 h after zymosan administration. Measuring IL-6, TNFα, and IL-1β pro-inflammatory cytokines released from LPS-stimulated THP-1 cells, calceolarioside A in a concentration-dependent manner reduced the release of these cytokines from THP-1 cells. Taken together, our results highlight, for the first time, the potential and selective anti-inflammatory properties of this natural-derived compound, prompting its rationale use for further investigations.

show abstract

Section: Discussionmentioning

confidence: 99%

Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A methanol extract of Picrorhiza kurroa rhizomes along with picrosides I II, III, and IV and 6-feruloylcatalpol, phenylethanoid glycosides, triterpene glycosides, cucurbitacin B 2-O-β-Dglucopyranoside and 25-acetoxy-2-β-D-glucopyranosyloxy-3,16,20trihydroxy-9-methyl-19-norlanosta-5-en-22-one, and an acetophenone glycoside, picein, exhibited collagenase inhibitory activity at 10-30 μM, with no cytotoxicity being observed at the effective concentrations [67].…”

Section: Anti-collagenase Activitymentioning

confidence: 99%

A Review on Chemical Constituents and Biological Activities of the Genus Picrorhiza (Scrophulariace)

Bhatnagar¹

2021

Int J Curr Pharm Sci

View full text Add to dashboard Cite

Picrorhiza (family Scrophulariace), commonly known as ‘kukti’ is a small perennial herb found in the Himalayan regions of China, Pakistan, India, Bhutan and Nepal at an altitude of 3000-5200 m. Different plant parts and its extract have traditionally been used as a remedy of various ailments such as fever, asthma, jaundice, anemia, abdominal pain, dysentery, cold, stomach problems. Picrorihza has been investigated for its chemical composition and biological activities by various researchers. The major chemical constituents found in this plant were iridoid glycosides, cucurbitacins (triterpenoids) glycosides, phenylethanoid glycosides and phenolics. The Picrorihza has various pharmacological properties, including hepto-protective, antimicrobial, anti-mutagenic, cardio-protective, anti-malarial, anti-diabetic, anti-cancer, anti-inflammatory, anti-ulcer, and neuroprotective and antioxidant activities. A thorough bibliographic investigation was carried out by analyzing worldwide scientific databases including Pub Med, Science Direct, Google Scholar and Wiley online as well as offline sources. The Present review is aimed to provide an updated overview of traditional uses, chemical constituents and biological activities of Picrorihza to explore its therapeutic potentials and to provide bases for future research.

show abstract

“…Picrorhiza kurroa , also known as Kutki, belongs to the Scrophulariaceae family and is a well-known herb in Ayurvedic medicine that is used for asthma, jaundice, fever, malaria, snake bite, and liver disorders, and is suggested to have antimicrobial, antioxidant, antibacterial, antimutagenic, cardioprotective, hepatoprotective, antimalarial, antidiabetic, anti-inflammatory, anticancer, anti-ulcer and nephroprotective properties [ 96 , 97 ]. A study by Morikawa et al showed that picein extracted from the rhizomes of Picrorhiza kurroa had favorable results on the promotion of collagen synthesis (at 10–30 μM) without cytotoxicity observed at effective concentrations [ 98 ]. Studying the antioxidative activity of picein extracted as one of the two phenol glycosides of this herb identified no such effect for picein, whereas the other compound of these leaves, luteolin-5-O-glucopyranoside, showed significant antioxidative properties [ 99 ].…”

Section: Antioxidative and Neuroprotective Properties Of Piceinmentioning

confidence: 99%

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Neurodegenerative diseases (NDDs) are the main cause of dementia in the elderly, having no cure to date, as the currently available therapies focus on symptom remission. Most NDDs will progress despite treatment and eventually result in the death of the patient after several years of a burden on both the patient and the caregivers. Therefore, it is necessary to investigate agents that tackle the disease pathogenesis and can efficiently slow down or halt disease progression, with the hope of curing the patients and preventing further burden and mortality. Accordingly, recent research has focused on disease-modifying treatments with neuroregenerative or neuroprotective effects. For this purpose, it is necessary to understand the pathogenesis of NDDs. It has been shown that oxidative stress plays an important role in the damage to the central nervous system and the progression of neurodegenerative disorders. Furthermore, mitochondrial dysfunction and the accumulation of unfolded proteins, including beta-amyloid (Aβ), tau proteins, and α-synuclein, have been suggested. Accordingly, cellular and molecular studies have investigated the efficacy of several natural compounds (herbs and nutritional agents) for their neuroprotective and antioxidative properties. The most popular herbs suggested for the treatment and/or prevention of NDDs include Withania somnifera (ashwagandha), ginseng, curcumin, resveratrol, Baccopa monnieri, and Ginkgo biloba. In some herbs, such as ginseng, preclinical and clinical evidence are available for supporting its effectiveness; however, in some others, only cellular and animal studies are available. In line with the scant literature in terms of the effectiveness of herbal compounds on NDDs, there are also other herbal agents that have been disregarded. Picein is one of the herbal agents that has been investigated in only a few studies. Picein is the active ingredient of several herbs and can be thus extracted from different types of herbs, which makes it more available. It has shown to have anti-inflammatory properties in cellular and plant studies; however, to date, only one study has suggested its neuroprotective properties. Furthermore, some cellular studies have shown no anti-inflammatory effect of picein. Therefore, a review of the available literature is required to summarize the results of studies on picein. To date, no review study seems to have addressed this issue. Thus, in the present study, we gather the available information about the antioxidative and potential neuroprotective properties of picein and its possible effectiveness in treating NDDs. We also summarize the plants from which picein can be extracted in order to guide researchers for future investigations.

show abstract

Collagen synthesis-promoting and collagenase inhibitory activities of constituents isolated from the rhizomes of Picrorhiza kurroa Royle ex Benth

Cited by 18 publications

References 69 publications

Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties

Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties

A Review on Chemical Constituents and Biological Activities of the Genus Picrorhiza (Scrophulariace)

The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature

Contact Info

Product

Resources

About