Collagen triple helix repeat containing-1 in the differential diagnosis of dermatofibrosarcoma protuberans and dermatofibroma

Abstract

We confirmed that Cthrc1 is a positive marker for DFSP and that Cthrc1 staining might be more reliable than markers traditionally used. Cthrc1 was not positive in absolutely [corrected] all cases of DFSP, and combination with CD34, factor XIIIa and ST3 immunostaining could make the distinction more reliable.

Elevated Plasma Levels of the Pituitary Hormone Cthrc1 in Individuals with Red Hair but Not in Patients with Solid Tumors

“…Microarray analyses have identified Cthrc1 as a gene overexpressed in many cancers [2], [3] [4] [5], [6], [7], [8], [9], [10], [11], [12] with reports of Cthrc1 localization in cancer cells as determined by immunohistochemistry. It does not appear that the specificity of any commercial antibody was verified using negative control tissues from Cthrc1 null species.…”

“…Since our discovery, Cthrc1 has frequently been identified as a gene upregulated in tumors based on microarray-based screening approaches [2]. Among the cancer cells reported to express Cthrc1 are melanomas [2], [3], hepatocellular carcinoma [4], oral cancer [5], breast ductal carcinoma [6], [7], pancreatic cancer [8], colorectal cancer [9], [10], gastric cancer [11], and dermatofibrosarcoma protuberans [12]. A recent study by Spector et al [13] reported expression of Cthrc1 in myofibroblasts in muscular dystrophies.…”

Collagen triple helix repeat containing 1 protein, periostin and versican in primary and metastatic breast cancer: an immunohistochemical study

“…These results suggest that CTHRC1 may be significant for tumour development, and suggest a more aggressive behaviour of breast cancer cells. Wang et al 27 have recently reported high levels of CTHRC1 in dermatofibrosarcoma protuberans, a locally aggressive spindle cell neoplasm that frequently recurs and metastasises.…”

Immunohistochemistry in Dermatopathology

“…Unlike CD34, which can be absent or decreased in fibrosarcoma- tous areas of DFSP (Figure 13, B), nestin remains unaltered. 250 Immunohistochemistry for stromelysin 3, a member of the matrix metalloproteinase family, MMP-11, has also been studied in at least 6 separate studies 46,238,[251][252][253][254] with similar outcomes. Stromelysin 3 has a role in tissue remodeling during wound healing and tumor invasion, and there is diffuse cytoplasmic staining of the spindle cells in most DFs, whereas it has rarely been noted in DFSPs.…”

“…Stromelysin 3 has a role in tissue remodeling during wound healing and tumor invasion, and there is diffuse cytoplasmic staining of the spindle cells in most DFs, whereas it has rarely been noted in DFSPs. 46,238,[251][252][253][254] Most DFSPs harbor the COL1A1-PDGFB translocation, and FISH can be used in cases showing confusing histopathologic and/or immunohistochemical features. 255 Positivity with CD117, an immunohistochemical marker that binds the KIT receptor, has shown an association with response to imatinib in gastrointestinal stromal tumors.…”