Collagen Tube Conduits in Peripheral Nerve Repair: A Retrospective Analysis

Wangensteen, Kirk J.; Kalliainen, Loree K.

doi:10.1007/s11552-009-9245-0

Cited by 140 publications

(99 citation statements)

References 13 publications

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“…Bushnell and colleagues [108] performed in 2008 a retrospective study of the utilization of collagen conduits in digital sensory nerve gaps of up to 20 mm and demonstrated a significant recovery rate of 89%. In a retrospective review, Wangensteen and Kalliaine [109] reported on a large number of sensory nerve gaps of 2.5-20 mm repaired with collagen conduits in multiple body regions and concluded that clinically successful outcomes were only observed in 43% of the cases. A prospective cohort study was performed by Lohmeyer and colleagues in 2009 [110] in digital and palmar nerve gaps of 6-18 mm, and results showed meaningful recovery in 75% of patients.…”

Section: Collagenmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Section: Collagenmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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show abstract

“…The commonly used degradable materials include collagen, 46,47 chitin, 48,49 polyglycolic acid (PGA), polylactic acid (PLA), glycolide, trimethylene carbonate, 50 etc. Rosen et al compared autologous nerve graft and PGA conduit to bridge 5 mm defects in rat femoral nerve.…”

Section: Degradable Nerve Conduitsmentioning

confidence: 99%

Progress of nerve bridges in the treatment of peripheral nerve disruptions

Ao¹

2016

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Clinical repair of a nerve defect is one of the most challenging surgical problems. Autologous nerve grafting remains the gold standard treatment in addressing peripheral nerve injuries that cannot be bridged by direct epineural suturing. However, the autologous nerve graft is not readily available, and the process of harvesting autologous nerve graft results in several complications. Thus, it is necessary to explore an alternative to autologous nerve graft. In the last few decades, with significant advances in the life sciences and biotechnology, a lot of artificial nerve grafts have been developed to aim at the treatment of peripheral nerve disruptions. Artificial nerve grafts range from biological tubes to synthetic tubes and from nondegradable tubes to degradable tubes. Among them, acellular nerve allografts and artificial nerve repair conduits are two kinds of the most promising substitutes for nerve autografts. The history, research status, and prospect of acellular nerve allografts and artificial nerve repair conduits are described briefly in this review.

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“…The rat CSF contains numerous neurotrophic factors (nerve growth factor, fibroblast growth factor 2, ciliary neurotrophic factor) enhance peripheral nerve regeneration and neuroprotection (32). These factors may enhance the migration of Schwann cells into the guide channel, as well as proliferation, growth cone attachment on the guide channel wall and so regenerating axon elongation (17).…”

Section: Sciatic Functional Index (Sfi)mentioning

confidence: 99%

“…Collagen molecules can easily trap neurotrophic factors and collagen channels are able to adsorb cell adhesion molecules (17). Another advantage of using the collagen as a NGCs is that the degradation speed of this biological material can be controlled by manipulating the thickness of the guide channel (32).…”

Section: Sciatic Functional Index (Sfi)mentioning

confidence: 99%

The effect of cerebro-spinal fluid in collagen guide channel on sciatic nerve regeneration in rat

Farjah

Dolatkhah²,

Pourheidar³

et al. 2015

Turkish Neurosurgery

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ABSTRACTgaps by inserting the severed nerve stumps into the two ends of the canal (16). Some natural and synthetic substances can be shaped in structures that are able to promote nerve regeneration for example: eggshell membrane (12), silicone (31), human amnion layer (22), collagen (18), collagen-Chitosan (36).Collagen-based biomaterials have been extensively studied as a promising nerve guide (7). Since collagen is a natural material, it shows excellent biocompatibility, insignificant immunogenicity, and high bio-absorbability (27).█ INTRODUCTION F or peripheral nerve repair, nerve autografts have always been considered as the "gold standard" for the restoration of structural and functional nerve regeneration (34).Autograft has several disadvantages, including the need for an extra-incision, loss of donor nerve function, mismatch in size between the donor nerve and the injured nerve, and a limited availability of donor nerve (33). To solve these problems, nerve guide channels (NGCs) have been made to bridge the nerve AIm: The aim of this study was to evaluate the effect of cerebrospinal fluid (CSF) in nerve regeneration across the collagen guide channel in comparison with autograft. mATERIAl and mEThODS: Forty adult male rats (250-300 g) were randomized into (1) collagen channel+CSF, (2) collagen channel+normal saline (NS), (3) autograft, and (4) sham surgery groups. The left sciatic nerve was exposed and a 10 mm nerve segment was cut and removed. In the collagen groups, the proximal and distal cuts ends of sciatic nerve were telescoped into the nerve guides and CSF or NS injected into collagen conduit. In the autograft group, the 10 mm nerve segment was turned backwards and used an autologous nerve graft. All animals were evaluated by sciatic functional index (SFI) and electrophysiology, histology, and immunohistochemistry testing. RESUlTS:The improvements in SFI since the beginning of the last evaluation in experimental groups were measured. On days 49 and 60 post-operation, the mean SFI of the collagen+CSF group was significantly greater than the autograft group (P< 0.05). On day 90, the mean nerve conduction velocity (NCV) of the collagen+CSF group was greater than autograft group (P< 0.05). The number of myelinated fibers in the collagen+CSF group was significantly greater than that of the collagen + NS group at day 90 (P<0.05).CONClUSION: CSF in collagen nerve guide channel effectively enhances nerve regeneration and promotes functional recovery in injured sciatic nerve of rats.

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Collagen Tube Conduits in Peripheral Nerve Repair: A Retrospective Analysis

Cited by 140 publications

References 13 publications

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Progress of nerve bridges in the treatment of peripheral nerve disruptions

The effect of cerebro-spinal fluid in collagen guide channel on sciatic nerve regeneration in rat

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