2012
DOI: 10.4103/0975-7406.100221
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Collagen with simvastatin promotes cell metabolism in osteoblast-like SaOS-2 cells

Abstract: Background:Simvastatin (SMV) is one of the cholesterol-lowering pharmacological drugs. Recent studies demonstrate that it has a bone stimulatory effect. The present study was designed to investigate the effect of SMV along with collagen membrane on osteoblast-like SaOS-2 cells and also to standardize the dosage of SMV to be incorporated into the collagen membrane to achieve regeneration.Materials and Methods:SMV at doses of 0.5, 1, 1.5, and 2 mg was incorporated into the collagen membrane and cell metabolism w… Show more

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