Collagenolytic Activity in Bovine Corneal Epithelium

Slansky, Harvey H.; Freeman, Melvin I.; Itoi, M

doi:10.1001/archopht.1968.00980050498018

Cited by 48 publications

(9 citation statements)

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“…Several authors have already claimed that the release of a collagenolytic enzyme from damaged epithelial cells is of considerable importance in the pathogenesis of corneal stromal ulceration (Slansky, Freeman and Itoi, 1968;Brown, Akiya and Weller, 1969;Itoi et al, 1969;Slansky et al, 1969). Brown et al have shown that the corneal ulcers and perforations, which inevitably occur with severe alkali burns, can be prevented by the use of collagenase inhibitors, and that though some degree of neovascularisation occurred in the cornea of control animals there was none in the inhibitor-treated corneas.…”

Section: Discussionmentioning

confidence: 99%

The fine structure of growing corneal lymphatic vessels

1971

The Journal of Pathology

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Section: Discussionmentioning

confidence: 99%

The fine structure of growing corneal lymphatic vessels

1971

The Journal of Pathology

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“…He pointed out the role of the epithelium in stromal ulceration, particularly the elaboration of collagenase by damaged epithelial cells. Slansky et al (1968 showed that cultured epithelium from human corneal ulcers released collagenase. Fetal calf and chick serum was shown to inhibit mammalian collagenase, but rabbit and human serum did not .…”

Section: Corneal Epithelial Outgrowthsmentioning

confidence: 99%

Biology in vitro of corneal epithelium and endothelium

Yanoff

1976

Doc Ophthalmol

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Four main areas were explored: 1) the proper medium for culturing corneal tissue; 2) the effect of serum on tissue growth in vitro; 3) the interrelationships in vitro between corneal epithelium and endothelium, and 4) the biology of cultures of whole corneas (organ cultures). Modified Eagle's minimal essential medium (MEM) proved to be an excellent culture fluid. Corneal tissue could be grown in MEM without serum or clot, thus providing a defined culture medium. The biology in vitro of outgrowths of multilayered corneal epithelium and monolayered corneal endothelium are discussed. Contact inhibition between epithelium and endothelium is demonstrated in whole corneal (organ) cultures.

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“…L azarus et al [1968] found that the granulocytes also pro duce it. Slansky et al [1968Slansky et al [ , 1970a and M cC ulley et al [1970] demon strated the collagenase activity of the corneal epithelial cells. According to Brown et al [1969Brown et al [ , 1970b, the stromal cells also produce the enzyme.…”

Section: Cell Activity In the Corneal Regenerationmentioning

confidence: 99%