Collagenolytic Fragments and Active Gelatinase Complexes in Periodontitis

Bildt, Miriam; Bloemen, Marjon; Kuijpers-Jagtman, Anne Marie; Hoff, Johannes W. Von den

doi:10.1902/jop.2008.080021

Cited by 30 publications

(28 citation statements)

References 45 publications

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“…In our study, nicotine administration caused a change in fibroblast activity due to the change of collagene fiber synthesis and decreased MMP2 expression. Several MMPs have been identified in the inflamed gingival tissues: MMP-1, -2, -3, -8, -9, -13, produced by the keratinocytes, macrophages, polymorphonuclear leukocytes [2,3,6,26,27]. Their activity could be different depending on the severity of disease and the needs for extracellular matrix digestion.…”

Section: Discussionmentioning

confidence: 99%

Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

et al. 2018

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Nicotine is associated with increased incidence of periodontal disease and poor response to therapy. This article aimed at identifying the expression of Matrix metalloproteinases-2 (MMP2) and Vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. In this experimental study, the groups were divided into nicotine and control groups. While the nicotine groups in rats (n=6) were administered 2mg/kg Nicotine sulphate for 28 days, the control group in rats (n=6) were only administered 1,5 ml physiologic saline solution subcutaneously for 28 days. Histological sections were prepared and immunohistochemically stained for MMP2 and VEGF. The sections were stained with Trichrome-Masson were observed under light microscope. VEGF and MMP2 immunoreactivity of periodontal gingiva and dentin was assessed by immunohistochemical staining. In conclusion, nicotine effect reduces Matrix metalloproteinases production and disrupt collagen synthesis and causes periodontitis. We observed that nicotine increases periodontitis by disrupting periodontal membrane and prevent tooth to anchor in dental alveoli by disrupting epithelial structure.

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Section: Discussionmentioning

confidence: 99%

Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

et al. 2018

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“…A similar pattern applies for MMP-9, which may not be affected by stretch (4, 11), but was found in this study to be trendwise (3-fold) downregulated by compression. In the clinic, active forms of MMP-2 and -9 have been inversely correlated with collagen fiber density (3), and both forms of MMP-2 are found in inflamed gingiva (3).…”

Section: Discussionmentioning

confidence: 99%

“…After 7-10 days of routine culture, fibroblasts were seen growing prolifically around the tissue pieces. At confluence, the cells were cryopreserved for later testing at passages [3][4][5][6]. In this study, a total of six cell lines were cultured from six individuals.…”

Section: Methodsmentioning

confidence: 99%

Pneumatic pressure bioreactor for cyclic hydrostatic stress application: mechanobiology effects on periodontal ligament cells

Wenger

El‐Awady²,

Messer³

et al. 2011

Journal of Applied Physiology

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“…Several MMPs have been identified in the inflamed gingival tissues: MMP-1, -2, -3, -8, -9, -13, produced by the keratinocytes, macrophages, polymorphonuclear leukocytes Bartold & Narayanan, 2006;Bildt et al, 2008;Kubota et al, 2008;Kumar et al, 2006). Their activity could be different depending on the severity of disease and the needs for extracellular matrix digestion.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%