Collagenous Colitis Associated with Protein Losing Enteropathy Presenting with Multiple Venous Thromboses

Raimo, John; Coronel, Mark; Criss, Adam; Storch, Ian

doi:10.14309/00000434-201010001-00943

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very rarely patients may develop protein-losing enteropathy and consequent hypoalbuminemia. [89][90][91] Because of the absence of validated laboratory biomarkers, the subjective impact on patients' quality of life can be used as an approximate for disease activity. Patients with less than 3 daily stools and less than one liquid present little or no effect on their perceived well-being, for which reason this definition has been proposed as a criterion for clinical remission by Hjortswang et al 31,92 Impact on patients' quality of life Although not objectively measurable, the selfreported patient quality of life is usually impaired.…”

Section: Diagnosismentioning

confidence: 99%

Microscopic colitis in older adults: impact, diagnosis, and management

Fedor

Zöld

Barta

2022

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

Microscopic colitis (comprising lymphocytic and collagenous colitis, albeit an incomplete variant is gaining recognition as well) is a chronic, immune-mediated inflammatory state of the lower gastrointestinal tract (colon). The diagnosis requires diagnostic colonoscopy with characteristic histopathological findings. They have a propensity to present in senior populations (above 60 years of age), particularly women – who are approximately 2.5–3 times more likely to develop microscopic colitis. Preexisting other immune-inflammatory diseases are also shown to predispose patients for the development of microscopic colitis. The classic presentation is profuse watery diarrhea, often during the night or early morning hours. Fecal incontinence and abdominal pain are frequent as well. Thus, the disease impacts patients’ quality of life and well-being. The first described cases date back to the seventies and eighties of the twentieth century, thereby they can be considered fairly recently discovered disease states. Our understanding of the disease and its pathophysiology is still incomplete. Although there is a lack of unified recommendation for treatment, most clinicians prefer the use of budesonide, and most published guidelines regard this locally acting glucocorticoid as the therapy of choice. In our article, we aimed for a brief, noncomprehensive overview of the clinical significance, diagnosis, and management of microscopic colitis.

show abstract

Section: Diagnosismentioning

confidence: 99%

Microscopic colitis in older adults: impact, diagnosis, and management

Fedor

Zöld

Barta

2022

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

show abstract

“…Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer [ 1 ]. However, CC has also been associated with six cases of protein-losing enteropathy (PLE) ([ 2 – 7 ]; Table 1 ), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Biopsy: collagenous colitis Therapy: oral corticosteroids with resolution of diarrhea. Pulmonary embolus treated with IV heparin as bridge to Coumadin Raimo et al [ 7 ] y. o. years old, F female, M male, WBC white blood cell (count), Hb hemoglobin, BUN blood urea nitrogen, GFR glomerular filtration rate, K potassium, IgA immunoglobulin A, IgG immunoglobulin G, AP alkaline phosphatase, TPN total parenteral nutrition, U/A urinalysis, CT computed tomography, 99m Tc HSA technetium-99m human serum albumin, PE physical exam, EGD esophagogastroduodenoscopy, HR heart rate, RR respiratory rate, BP blood pressure, T temperature …”

Section: Introductionmentioning

confidence: 99%

Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis

et al. 2021

View full text Add to dashboard Cite

Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Collagenous duodenitis (CD) has not been associated with PLE. This work reports a novel case of CD (and CC) associated with PLE; a pathophysiologically reasonable mechanism for CD causing PLE (by the thick collagen layer of CD blocking normal intestinal amino acid absorption); and a novel association of PLE with severe COVID-19 infection (attributed to relative immunosuppression from hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and malnutrition from PLE).

show abstract

Collagenous Colitis Associated with Protein Losing Enteropathy Presenting with Multiple Venous Thromboses

Cited by 2 publications

References 0 publications

Microscopic colitis in older adults: impact, diagnosis, and management

Microscopic colitis in older adults: impact, diagnosis, and management

Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis

Contact Info

Product

Resources

About