Collagenous crystalloids in pleomorphic adenoma of the parotid gland

Okano, Kimiaki; Arimoto, Tomoko; Ishida, Mitsuaki; Sandoh, Kaori; Fujisawa, Takuo; Iwai, Hiroshi; Tsuta, Koji

doi:10.1002/dc.24149

Cited by 2 publications

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References 3 publications

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“…13 Collagenrich crystalloids, which have been described as radially arranged collagen fibers around a clear central area, have also been identified in pleomorphic adenomas as well as in myoepitheliomas. [14][15][16] Fine-needle aspiration (FNA) is a well established and important method for characterizing and triaging salivary gland lesions, 17 and results are reported using the recently published Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). 18 Overall, finding crystalloids on salivary gland cytology is relatively uncommon.…”

Section: Introductionmentioning

confidence: 99%

Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute

Faquin

Torous

2020

Cancer Cytopathology

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BACKGROUND:Identifying crystalloids, which includes amylase and tyrosine crystalloids, is relatively uncommon in salivary gland fine-needle aspiration (FNA) cytology. Although it has been suggested that the presence of crystalloids favors a benign process, the full significance has not been well established. METHODS: The authors performed a review of slides from all salivary gland FNA cases received in their laboratory from January 2017 to September 2019 to identify cases with crystalloids (screened cohort). In addition, the departmental archives were searched retrospectively for all salivary gland FNA cases that had specifically reported crystalloids. Cytologic findings as well as correlation with surgical pathology and clinical follow-up were examined. RESULTS: There were 664 cases in the screened cohort. Crystalloids were present in 37 cases (incidence, 5.6%). Amylase crystalloids were the most commonly identified (n = 28; 75%), followed by tyrosine crystalloids (n = 4; 11%), and collagenous crystalloids (n = 1; 3%). Four cases with crystalloids could not be further classified because of low quantity (n = 4; 11%). An additional 54 cases were identified in the 10-year retrospective review. Diagnostic categorization for the total cohort (N = 91) was as follows: nondiagnostic, 30 cases (33%); nonneoplastic/benign, 42 cases (46%); neoplasm: benign, 10 cases (11%); and atypia of undetermined significance, 9 cases (10%). Twenty-six cases had subsequent resection findings, including oncocytic cyst/cystadenoma in 8 cases (31%), chronic sialadenitis/ductal obstructive change in 7 cases (27%), pleomorphic adenoma in 5 cases (27%), developmental cyst in 3 cases (12%), lymphoepithelial cyst in 2 cases (8%), and Warthin tumor in 1 case (4%). CONCLUSIONS: This cohort represents the largest FNA series of salivary gland crystalloids. All cases were associated with nonneoplastic or benign neoplastic lesions.

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Section: Introductionmentioning

confidence: 99%

Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute

Faquin

Torous

2020

Cancer Cytopathology

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Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology

Ishida,

Kataoka,

Tomiuka

et al. 2024

Mol Clin Oncol

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Lymphoepithelial cysts (LECs) of the salivary glands are relatively rare, benign cystic lesions. Characteristic histopathological features of LEC include presence of well-circumscribed unilocular cysts surrounded by dense lymphoid tissue with lymphoid follicles. These cysts are lined by a combination of squamous, ciliated, columnar and mucous epithelia. Fine-needle aspiration (FNA) cytology is the standard preoperative diagnostic procedure for salivary gland lesions. Although the cytological diagnosis of cystic salivary gland lesions is difficult, the use of Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) in the cytodiagnosis of cystic salivary gland lesions has been reported. However, only a few studies have described the cytological features of LEC. To the best of our knowledge, the present study reviewed the cytological features of a case series of LEC and evaluated the application of MSRSGC for the first time. This retrospective study included 13 patients with LEC of the salivary glands who underwent pre-operative FNA followed by surgical resection of the cyst. All the lesions were present in the parotid gland. Cytological analysis revealed no epithelial cell component in eight patients (62.5%) along with a proteinaceous background containing lymphocytes and/or foamy cells. Non-keratinising squamous epithelium was observed in three patients. Amylase crystalloids were noted in two patients. None of the patients were cytodiagnosed with LEC. Eight, three, one and one patients were categorised as MSRSGC I, II, III, and IVa, respectively. The results of the present study demonstrated that cytodiagnosis of LEC was difficult due to the absence of epithelial component in 62.5% of the specimens. However, evaluation of its benignity was not difficult. Thus, it can be summarized that MSRSGC may be useful for cytological evaluation of LECs.

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Collagenous crystalloids in pleomorphic adenoma of the parotid gland

Cited by 2 publications

References 3 publications

Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute

Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute

Cytological features of a lymphoepithelial cyst of the salivary gland with application of the second edition of Milan System for Reporting Salivary Gland Cytopathology

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