Collagenous gastritis: Review

Abstract

Collagenous gastritis is a rare disease characterized by the subepithelial deposition of collagen bands thicker than 10 μm and the infiltration of inflammatory mononuclear cells in the lamina propria. Collagenous colitis and collagenous sprue have similar histological characteristics to collagenous gastritis and are thought to be part of the same disease entity. However, while collagenous colitis has become more common in the field of gastroenterology, presenting with clinical symptoms of chronic diarrhea in older patients, collagenous gastritis is rare. Since the disease was first reported in 1989, only 60 cases have been documented in the English literature. No safe and effective treatments have been identified from randomized, controlled trials. Therefore, better understanding of the disease and the reporting of more cases will help to establish diagnostic criteria and to develop therapeutic strategies. Therefore, here we review the clinical characteristics, endoscopic and histological findings, treatment, and clinical outcomes from case reports and case series published to date, and provide a summary of the latest information on the disease. This information will contribute to improved knowledge of collagenous gastritis so physicians can recognize and correctly diagnose the disease, and will help to develop a standard therapeutic strategy for future clinical trials.

Collagenous Gastritis in a Young Female With IgA Deficiency

“…There are no reports of any association between collagenous gastritis and any malignancy, lymphoma or any other gastric disorders [4]. The course and prognosis of the disease is still unclear.…”

Collagenous gastritis: a case report

“…17 However, in most cases, the collagen deposits remain unchanged or become thicker as a result of continued inflammation. 1 There are number of potential pitfalls in diagnosing CG. Considering the rarity of this condition with respect to collagenous deposition at other gastrointe-kLinični PriMer stinal sites, CG may be underdiagnosed.…”

“…18 The other endoscopic findings include mucosal erythema, erosions and exudate. 1,12 The diagnosis of CG is made by histology -in order to make a diagnosis it is necessary to take biopsy specimens according to the updated Sydney protocol: two specimens from the antrum, two specimens from the corpus and one specimen from the incisura angularis. Especially in the early stages, the disease can be unevenly distributed over the gastric mucosa, thus it is important to take at least five specimens.…”

Collagenous Gastritis Observed by Magnifying Narrow-Band Imaging Endoscopy

“…Further investigations including capsule endoscopy and colonoscopy with biopsies did not show any sign of collagenous sprue or collagenous colitis. We diagnosed this case as collagenous gastritis (CG).Endoscopic findings in CG have been characterized by fine and fading nodularity surrounded by slightly depressed, atrophic mucosa [1]. Pathologically, dense collagen depositions are found in the intervening, atrophied mucosa, whereas the nodules contain mild inflammatory infiltrates without thickened collagen bands [1,2].…”

“…Pathologically, dense collagen depositions are found in the intervening, atrophied mucosa, whereas the nodules contain mild inflammatory infiltrates without thickened collagen bands [1,2]. However, little has been…”