Collagenous Spherulosis Associated with Adenomyoepithelioma of the Breast

Ohta, Makoto; Mori, Masaki; Kawada, Takako; Maegawa, Hideki; Yamamoto, Shiro; Imamura, Yoshiaki

doi:10.1159/000325041

Cited by 4 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apocrine metaplasia of the luminal cells is common and squamous metaplasia is also often encountered,34 together with focal sebaceous differentiation14 34 (figure 4). AMEs rarely contain foci of collagenous spherulosis 35 36. The myoepithelial cells in AME are usually much more numerous and larger than those seen in normal breast lobules, adenosis nodules or simple papillomas.…”

Section: Histopathological Featuresmentioning

confidence: 99%

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Hayes¹

2011

J Clin Pathol

131

View full text Add to dashboard Cite

This review describes the classification, clinical presentation, pathological features and clinical behaviour of adenomyoepithelioma (AME) of the breast. It is based on an extensive review of the literature and study of a collection of cases built up over a 17-year period at the British Columbia Cancer Agency. The diversity of the morphology encountered in both benign and malignant AME is described. The behaviour of malignant AME seems to be related to the grade of the malignant component.

show abstract

Section: Histopathological Featuresmentioning

confidence: 99%

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Hayes¹

2011

J Clin Pathol

131

View full text Add to dashboard Cite

show abstract

“…CS has been frequently seen in association with benign breast lesions such as sclerosing adenosis, radial scar, intraductal papilloma, fibroadenoma, adenomyoepithelioma, and atypical ductal hyperplasia. [ 2 3 ]…”

Section: Discussionmentioning

confidence: 99%

Collagenous spherulosis: An interesting cytological finding in breast lesion

2015

View full text Add to dashboard Cite

Collagenous spherulosis (CS) is a rare and interesting entity associated with benign breast lesions. CS is an incidental finding picked up only on 0.2% of cytology specimen. Typically cytologically of CS of breast consists of central spherical hyaline spherule surrounded by myoepithelial cells. The central hyaline spherule has been found to be basement membrane material histochemically and immunohistochemically. The importance of recognizing CS of breast lies in the fact that similar hyaline globules can occur in adenoid cystic carcinoma of the breast (ACCB). The two lesions need to be differentiated on cytology failing which inappropriate treatment can be given for either of the two lesions. We present here a case of CS associated with benign breast lesion and a case of ACCB to describe their cytological features and key points to differentiate them cytologically.

show abstract

“…It has been frequently seen in association with benign proliferative lesions of the breast, including sclerosing adenosis, radial scar, intraductal papilloma, fibroadenoma, adenomyoepithelioma, atypical ductal hyperplasia, etc. [23]…”

Section: Introductionmentioning

confidence: 99%

Cytological diagnosis of collagenous spherulosis of breast

Gokhale

Nanda

Pillai

2014

J Cytol

View full text Add to dashboard Cite

Collagenous spherulosis is a rare entity usually seen in association with benign breast lesions. It is often picked up incidentally with a reported incidence of about 0.2% in cytological material. There are very few reports describing cytomorphological features of collagenous spherulosis. To the best of our knowledge this is the only case reported from the middle-east region. The presence of hyaline spherules surrounded by a single layer of benign myoepithelial cells is the hallmark of collagenous spherulosis on FNA. However, due to close cytological resemblance, it can be misdiagnosed as adenoid cystic carcinoma of the breast. A 40-year-old woman presented with a history of a painless lump in the infraareolar region of left breast for a year. Fine needle aspiration was performed. The smears showed scanty cellularity comprising of cohesive clusters and a few branching fragments of benign ductal epithelial cells closely intermingled with many spherical, acellular homogenous hyaline globules. Few bare bipolar nuclei were noted in the background. A diagnosis of collagenous spherulosis associated with benign proliferative breast disease was made. Cytopathologists need to be aware of this entity in order to differentiate it from adenoid cystic carcinoma of the breast which requires radical treatment.

show abstract

Collagenous Spherulosis Associated with Adenomyoepithelioma of the Breast

Cited by 4 publications

References 14 publications

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

Collagenous spherulosis: An interesting cytological finding in breast lesion

Cytological diagnosis of collagenous spherulosis of breast

Contact Info

Product

Resources

About