Based on a nine-story ancient pagoda with important historical and cultural value in Guangxi, China, this study simulated the collapse process of the ancient pagoda under different explosion points by using the fluid-structure coupling method, which can better explore the explosion-proof performance of the ancient pagoda. By constructing the finite element model of 5 explosion points, it is found that the area closest to the explosion point is the most seriously damaged, and the damage of the front explosion surface is obviously higher than that of the back explosion surface. In addition, the study shows that the response of the pagoda body is more severe and the damage is more serious when the number of blasting layers is 3, 5 and 7. In order to optimize the explosion-proof design, it is suggested to strengthen the structure of the surface of the explosion facing, improve the support system and masonry connection mode, and pay attention to the safety margin in the middle area of the pagoda body, so as to provide an effective scheme for the protection technology of the ancient pagoda.