Collapse of human scalp microbiome network in dandruff and seborrhoeic dermatitis

Park, Taehun; Kim, Hye-Jin; Myeong, Nu Ri; Lee, Hyun Gee; Kwack, Ilyoung; Lee, John-Hwan; Kim, Beom Joon; Sul, Woo Jun; An, Shi

doi:10.1111/exd.13293

Cited by 89 publications

(114 citation statements)

References 9 publications

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“…In general, Malassezia spp. were found to be more abundant on dandruff scalp compared to healthy scalp 47, 48, 50. In addition to the mycobiota, a dysbiosis in Staphylococcus and Propionibacterium spp.…”

Section: Resultsmentioning

confidence: 95%

“…Four case–control studies investigated the microbiome in SD patients 47, 48, 49, 50, Table 1. In general, Malassezia spp.…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the mycobiota, a dysbiosis in Staphylococcus and Propionibacterium spp. was described in microbiota analysis 48, 50. One of the four studies did not find a general association between Malassezia spp.…”

Section: Resultsmentioning

confidence: 99%

“…However, future studies will have to confirm this potential. In SD, three different sequencing methods were used in the three different studies 47, 49, 50. This, together with the small sample populations, single time point sampling and poor study designs, might explain the heterogeneity in findings.…”

Section: Discussionmentioning

confidence: 99%

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A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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AimsTo explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC).MethodsA systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method.ResultsIn total, 841 papers were identified and after screening of titles and abstracts for eligibility we identified 42 manuscripts that could be included in the review. Eleven studies were included for AD, five for AV, 10 for PV, two for HS, four for SD and 10 for UC. For AD and AV, multiple studies report the relationship between the skin microbiome, disease severity and clinical response to treatment. This is currently lacking for the remaining conditions.ConclusionFor two indications – AD and AV – there is preliminary evidence to support implementation of the skin microbiome as biomarkers in early phase clinical trials. For PV, UC, SD and HS there is insufficient evidence from the literature. More microbiome‐directed prospective studies studying the effect of current treatments on the microbiome with special attention for patient meta‐data, sampling methods and analysis methods are needed to draw more substantial conclusions.

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Section: Resultsmentioning

confidence: 95%

“…Four case–control studies investigated the microbiome in SD patients 47, 48, 49, 50, Table 1. In general, Malassezia spp.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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“…Propionibacterium был выявлен в изоби-лии на участках без повреждений, тогда как Acinetobacter, Staphylococcus и Streptococcus преобладали на участках поражения. Изуче-ние микробного состава поверхности кожи больных себорейным дерматитом показало, что даже сапрофитные и условно-патогенные микроорганизмы могут реализовывать свои патогенные свойства, что обусловливает более тяжелое течение дерматита у больных жирной формой себорейного дерматита с частым воз-никновением осложнений [66,68,69].…”

Section: изменения микробиоты при заболеваниях кожиunclassified

Микробиота Кожи И Возможности Ее Коррекции Пре- И Пробиотиками При Лечении Хронических Дерматозов

Litus¹,

Martyniuk²,

Bardova³

2017

Inter. jour. antoboit. and probiot.

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В последнее время достигнут прогресс в понимании значения микробиома для здоровья человека и его роли в развитии заболеваний. Изучение изменений микробиоты кожи при хронических дерматозах помогает понять этиологию и патогенез заболеваний, что важно для разработки стратегии лечения. Перспективным направлением является применение пре- и пробиотиков для модуляции кожной микробиоты с целью улучшения состояния кожи.

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A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?

et al. 2021

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Dandruff is a common scalp condition, which frequently causes psychological distress in those affected. Dandruff is considered to be caused by an interplay of several factors. However, the pathogenesis of dandruff remains under‐investigated, especially with respect to the contribution of the hair follicle. As the hair follicle exhibits unique immune‐modulatory properties, including the creation of an immunoinhibitory, immune‐privileged milieu, we propose a novel hypothesis taking into account the role of the hair follicle. We hypothesize that the changes and imbalance of yeast and bacterial species, along with increasing proinflammatory sebum by‐products, leads to the activation of immune response and inflammation. Hair follicle keratinocytes may then detect these changes in scalp microbiota resulting in the recruitment of leukocytes to the inflammation site. These changes in the scalp skin immune‐microenvironment may impact hair follicle immune privilege status, which opens new avenues into exploring the role of the hair follicle in dandruff pathogenesis. Also see the video abstract here: https://youtu.be/mEZEznCYtNs

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Collapse of human scalp microbiome network in dandruff and seborrhoeic dermatitis

Abstract: We investigate the relationship between scalp microbiota and dandruff/seborrhoeic dermatitis (D/SD), an unpleasant scalp disorder common in human populations. Bacterial and fungal community analyses on scalp of 102 Korean were performed by next-generation sequencing.

Cited by 89 publications

References 9 publications

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Микробиота Кожи И Возможности Ее Коррекции Пре- И Пробиотиками При Лечении Хронических Дерматозов

A folliculocentric perspective of dandruff pathogenesis: Could a troublesome condition be caused by changes to a natural secretory mechanism?

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