2024
DOI: 10.1101/2024.12.04.626580
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Collapse of Interictal Suppressive Networks Permits Seizure Spread

Ghassan S. Makhoul,
Derek J. Doss,
Graham W. Johnson
et al.

Abstract: How do networks in the brain limit seizure activity? In the Interictal Suppression Hypothesis (ISH), we recently postulated that high inward connectivity to seizure onset zones (SOZs) from non-involved zones (NIZs) is a sign of broader network suppression at rest. If broad networks appear to be responsible for interictal SOZ suppression, what changes during seizure initiation, spread, and termination? For patients with drug resistant epilepsy, intracranial monitoring offers a view into the electrographic netwo… Show more

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