Collapsibility of the internal jugular veins in the lateral decubitus body position: A potential protective role of the cerebral venous outflow against neurodegeneration

Simka, Marian; Czaja, Joanna; Kowalczyk, Dariusz

doi:10.1016/j.mehy.2019.109397

Cited by 12 publications

(12 citation statements)

References 36 publications

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“…In the supine body position a majority of blood flows out of the brain through the IJVs, while in the sitting or standing humans a substantial part of outflow is shifted toward the vertebral veins, a valveless system which includes the vertebral veins, and paravertebral and intraspinal venous plexuses. [21][22][23][24] In the latter positions, because of a negative transmural pressure in the IJVs, these veins partially collapse, which in turn significantly increases the flow resistance and consequently the outflow is directed to the vertebral veins that do not significantly collapse. Because of this phenomenon, an impaired flow through the IJV could potentially exhibit clinical consequences only in the decubitus body position, which primarily occurs during sleep.…”

Section: Discussionmentioning

confidence: 99%

Numerical modeling of blood flow in the internal jugular vein with the use of computational fluid mechanics software

Simka

Latacz

2021

Phlebology

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Objectives To determine the site and nature of altered hemodynamics in pathological internal jugular veins. Method With the use of computational fluid mechanics software we simulated blood flow in 3 D models of the internal jugular veins that exhibited different morphologies, including nozzle-like strictures in their upper parts and valves in the lower parts. Results In a majority of models with nozzle-like strictures, especially those positioned asymmetrically, abnormal flow pattern was revealed, with significant flow separation and regions with reversed flow. Abnormal valves had no significant impact on flow in a case of already altered flow evoked by stricture in upper part of the vein. Conclusions In our jugular model, cranially-located stenoses, which in clinical practice are primarily caused by external compression, cause more significant outflow impact respect to endoluminal defects and pathological valves located more caudally.

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Section: Discussionmentioning

confidence: 99%

Numerical modeling of blood flow in the internal jugular vein with the use of computational fluid mechanics software

Simka

Latacz

2021

Phlebology

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“…Interestingly, in patients with obstructive sleep apnea the use of positive airway pressure machines increases SWS, and SWS is significantly correlated with lower Aβ levels after treatment. Lastly, body position during sleep could also be crucial for protection against neurodegeneration: in the lateral decubitus position, decreased flow resistance is observed in the extracranial veins, with optimal cerebral venous outflow, which in turn optimizes glymphatic system function [ 8 ].…”

mentioning

confidence: 99%

Sleep disorders and increased risk of dementia

Ferini‐Strambi

2022

Euro J of Neurology

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“…Recently, elevated sleeping posture has been studied at high altitudes and did not show efficacy in preventing AMS [ 67 ]. However, in light of this finding, research suggests that, instead, lateral sleeping posture may be key to increasing glymphatic and cerebral venous drainage, therefore facilitating cerebral fluid homeostasis [ 68 , 69 ]. Thus, such an intervention may warrant further investigation in the setting of HACE prevention.…”

Section: Emerging Discoverymentioning

confidence: 99%

High Altitude Cerebral Edema: Improving Treatment Options

et al. 2022

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High altitude illness in its most severe form can lead to high altitude cerebral edema (HACE). Current strategies have focused on prevention with graduated ascents, pharmacologic prophylaxis, and descent at first signs of symptoms. Little is understood regarding treatment with steroids and oxygenation being commonly utilized. Pre-clinical studies with turmeric derivatives have offered promise due to its anti-inflammatory and antioxidant properties, but they warrant validation clinically. Ongoing work is focused on better understanding the disease pathophysiology with an emphasis on the glymphatic system and venous outflow obstruction. This review highlights what is known regarding diagnosis, treatment, and prevention, while also introducing novel pathophysiology mechanisms warranting further investigation.

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Collapsibility of the internal jugular veins in the lateral decubitus body position: A potential protective role of the cerebral venous outflow against neurodegeneration

Cited by 12 publications

References 36 publications

Numerical modeling of blood flow in the internal jugular vein with the use of computational fluid mechanics software

Numerical modeling of blood flow in the internal jugular vein with the use of computational fluid mechanics software

Sleep disorders and increased risk of dementia

High Altitude Cerebral Edema: Improving Treatment Options

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