Collateral circulation on <scp>p</scp>erfusion‐<scp>c</scp>omputed <scp>t</scp>omography‐<scp>s</scp>ource <scp>i</scp>mages predicts the response to stroke intravenous thrombolysis

Calleja, Ana; Cortijo, Elisa; García-Bermejo, Pablo; Gómez, R. D.; Pérez-Fernández, Santiago; Monte, J. M. del; Muñoz, M. F.; Fernández-Herranz, R; Arenillas, Juan F.

doi:10.1111/ene.12063

Cited by 67 publications

(73 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predictive value of the morphologic extent is consistent with previous reports using dynamic CTA and other imaging techniques. 4,14,26 Notably, both delay and extent remained independent predictors after correcting for IV thrombolysis and mechanical thrombectomy. This suggests the beneficial effect of good collateralization in dynamic CTA, even in the absence of interventions.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Predictive Value of the Velocity of Collateral Filling in Patients with Acute Ischemic Stroke

Beyer¹,

Baumgarten

Thierfelder³

et al. 2014

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

The velocity of collateral filling can be assessed in dynamic time-resolved computed tomography (CT) angiographies and may predict initial CT perfusion (CTP) and follow-up lesion size. We included all patients with an M1 ± internal carotid artery (ICA) occlusion and follow-up imaging from an existing cohort of 1791 consecutive patients who underwent multimodal CT for suspected stroke. The velocity of collateral filling was quantified using the delay of time-to-peak (TTP) enhancement of the M2 segment distal to the occlusion. Cerebral blood volume (CBV) and mean transit time (MTT)-CBV mismatch were assessed in initial CTP. Follow-up lesion size was assessed by magnetic resonance imaging (MRI) or non-enhanced CT (NECT). Multivariate analyses were performed to adjust for extent of collateralization and type of treatment. Our study comprised 116 patients. Multivariate analysis showed a short collateral blood flow delay to be an independent predictor of a small CBV lesion (P o 0.001) and a large relative mismatch (P o 0.001) on initial CTP, of a small follow-up lesion (P o 0.001), and of a small difference between initial CBV and follow-up lesion size (P = 0.024). Other independent predictors of a small lesion on follow-up were a high morphologic collateral grade (P = 0.001), lack of an additional ICA occlusion (P = 0.009), and intravenous thrombolysis (P = 0.022). Fast filling of collaterals predicts initial CTP and follow-up lesion size and is independent of extent of collateralization.

show abstract

Section: Discussionmentioning

confidence: 95%

“…Using this approach, a comprehensive assessment of the watershed of collaterals over the entire scan time has been shown to predict clinical outcome. [13][14][15] However, little is yet known about the value of analyzing the temporal aspects of the filling of leptomeningeal collateral vessels.…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of the Velocity of Collateral Filling in Patients with Acute Ischemic Stroke

Beyer¹,

Baumgarten

Thierfelder³

et al. 2014

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…These collaterals can also predict the effectiveness of intravenous thrombolysis as well as various endovascular interventions [3]. Furthermore, good collaterals reduce hemorrhagic complications of various therapeutic strategies in AIS [3].…”

mentioning

confidence: 99%

Intracranial Collaterals: The Next Frontier in Acute Ischemic Stroke?

Sharma¹

2014

Brain Disord Ther

View full text Add to dashboard Cite

“…1,2 The extent of collateralization is an independent predictor of a small-lesion volume on follow-up imaging 3 and a favorable clinical outcome. 4 It has been further shown to predict response to intravenous thrombolysis 5 and to determine penumbral tissue loss. 6 Noninvasive imaging of collaterals can be performed by using CT angiography 7,8 or MR angiography.…”

mentioning

confidence: 99%

“…Its value in assessing the maximal extent of collateralization has been shown in several studies. 5,17,18 However, the time point of image analysis might play an important role in correctly assessing the prognostic value of the collateralization.…”

mentioning

confidence: 99%

Strategies of Collateral Blood Flow Assessment in Ischemic Stroke: Prediction of the Follow-Up Infarct Volume in Conventional and Dynamic CTA

Beyer¹,

Thierfelder²,

Baumgarten³

et al. 2014

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Collateral circulation on perfusion‐computed tomography‐source images predicts the response to stroke intravenous thrombolysis

Abstract: A higher degree of LMC assessed by PCT-SI predicts good response to iv thrombolysis in MCA ischaemic stroke patients.

Cited by 67 publications

References 16 publications

Predictive Value of the Velocity of Collateral Filling in Patients with Acute Ischemic Stroke

Predictive Value of the Velocity of Collateral Filling in Patients with Acute Ischemic Stroke

Intracranial Collaterals: The Next Frontier in Acute Ischemic Stroke?

Strategies of Collateral Blood Flow Assessment in Ischemic Stroke: Prediction of the Follow-Up Infarct Volume in Conventional and Dynamic CTA

Contact Info

Product

Resources

About