Collateral ventilation of obstructed lung during high-frequency oscillation in dogs and pigs

Takeda, Junzo; Cf, Mackenzie; Watson, Robert J.; Hg, Roberts; Moorman, Robert; Bh, Hoff; Wilson, Douglas F.; Gs, Johnston; Jl, Hill

doi:10.1097/00003246-198709000-00012

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the mechanism is unclear, adequate gas exchange in pigs can be achieved by means of pure high frequency ventilation [4]. Collateral ventilation is excluded as it is very limited in pigs [13]. If high frequency alone is an effective mode of ventilation, adding high frequency to other modes may have an additive effect on either oxygenation or CO2 washout or both in pigs.…”

Section: Discussionmentioning

confidence: 99%

A comparison of continuous positive pressure ventilation, combined high frequency ventilation and airway pressure release ventilation on experimental lung injury

1992

View full text Add to dashboard Cite

In pigs with oleic induced lung injury, the effectiveness of combined high frequency ventilation (CHFV, with VDR-Phasitron) and airway pressure release ventilation (APRV) were compared to continuous positive pressure ventilation (CPPV) in a randomized study. The respiratory rate was 15/min, CPAP 8 mmHg and FiO2 0.25. PaCO2 was maintained at 5 kPa. PaO2 was significantly lower with APRV (12.5 +/- 3.9 kPa, CPPV: 15.8 +/- 3.9 kPa, and CHFV: 15.5 +/- 3.2 kPa). This was in accordance with the lowest peak airway pressure during APRV (20.9 +/- 4.8 mmHg, CPPV: 26.3 +/- 4.4 mmHg and CHFV: 28.2 +/- 3.7 mmHg). There was no difference in the pericardiac pressure between the 3 ventilation modes. The pressure related depressive effects on the cardiovascular function during CHFV and APRV were similar to those during CPPV. Adequate oxygenation and ventilation could be achieved with both CHFV and APRV, but these methods were not superior to CPPV.

show abstract

Section: Discussionmentioning

confidence: 99%

A comparison of continuous positive pressure ventilation, combined high frequency ventilation and airway pressure release ventilation on experimental lung injury

1992

View full text Add to dashboard Cite

show abstract

“…The mechanism of action of HFV in the lung of the pig is unclear. The influence of collateral ventilation is excluded because of its very limited nature (13). At a certain lung volume or lung distension level, HFV might have its optimal effect.…”

Section: Cppvmentioning

confidence: 99%

The effect of combined high frequency ventilation with and without continuous positive airway pressure in experimental lung injury

Jousela

Måkelãinen

Linko

1992

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Combined high frequency ventilation (CHFV) with 8 mmHg (1.0 kPa) continuous positive airway pressure (CPAP) and without CPAP (CHFV0) were compared to each other, and to continuous positive pressure ventilation (CPPV) with 8 mmHg (1.0 kPa) CPAP in pigs with oleic acid induced lung injury. The respiratory rate was 15 min-1 and the high frequency (HF) rate 360 min-1. Arterial carbon dioxide tension (PaCO2) was adjusted to 5 kPa and 25% oxygen was used. After CHFV, CPAP was briefly discontinued to allow the establishment of CHFV0 in order to examine the cardiovascular and pulmonary effects of combined high frequency ventilation alone. Mean arterial oxygen tension (PaO2) was 15.8 +/- 3.9 kPa during CPPV, 15.5 + 3.2 kPa during CHFV and 13.2 +/- 5.1 kPa during CHFV0 (ns). The peak airway pressure and the pericardiac pressure were lowest during CHFV0. CHFV provoked significant cardiovascular depression (mean arterial pressure, stroke index, left and right ventricle stroke work index). When compared to CPPV, a non-significant trend towards improved cardiovascular function was found during CHFV0. With similar mean airway pressures (during CHFV0) or the same CPAP (during CHFV) as during CPPV, no further improvement in oxygenation due to HF waves was found. Airway pressure was the major factor causing alterations in cardiovascular function, not the ventilation technique.

show abstract

“…These findings may be explained as follows: during high frequency ventilation collateral ventilation has marked influence on lung volumes and gas exchange, presumably by decreasing maldistribution of regional ventilation. Interregional gas exchange has been demonstrated in dogs and to some extent in humans, too, particularly in patients with COPD [24], in the presence of regional differences of lung volume and pressure [25], and during high frequency oscillation ventilation [26].…”

Section: Hfjv In Panlobular Emphysemamentioning

confidence: 99%

High frequency jet ventilation in experimental pulmonary emphysema

et al. 1991

View full text Add to dashboard Cite

The effects of high frequency jet ventilation (HFJV, f = 2 Hz and 8 Hz, I:E = 0.43, FiO2 = 0.4) were studied and compared with intermittent positive pressure ventilation (IPPV, f = 10-14 breaths/min, VT = 15 ml/kg, I:E = 0.5, FiO2 = 0.4) in 8 dogs before and after induction of panlobular emphysema (PLE). PLE increased alveolar-arterial PO2 difference (PA-aO2) during all modes of ventilation, whereas PaCO2 did not change significantly. In both periods of the study, HFJV8 Hz was less effective in terms of CO2-elimination and oxygenation. In the control-period, functional residual capacity (FRC) was 937 +/- 212 ml. The increase during HFJV (HFJV2 Hz: 1156 +/- 508 ml, HFJV8 Hz: 1153 +/- 433 ml) did not reach significance (P = 0.09). Closing volume (CV) increased from 1.5 +/- 4.3% of vital capacity (%VC) (IPPV) to 6.3 +/- 7.1%VC (HFJV2 Hz) and 10.8 +/- 9.8% VC (HFJV8 Hz), respectively. In the PLE-period, FRC and CV increased significantly to 1107 +/- 207 ml and 14.1 +/- 7.0% VC respectively during IPPV (P less than 0.05). Application of HFJV neither increased FRC (HFJV2 Hz: 1153 +/- 433 ml, HFJV8 Hz: 1005 +/- 344 nor CV 14.8 +/- 6.0% VC and 13.9 +/- 8.1% VC, respectively). It is concluded that HFJV induces no alveolar overdistension in dogs with emphysematous lungs.

show abstract

Collateral ventilation of obstructed lung during high-frequency oscillation in dogs and pigs

Cited by 7 publications

References 0 publications

A comparison of continuous positive pressure ventilation, combined high frequency ventilation and airway pressure release ventilation on experimental lung injury

A comparison of continuous positive pressure ventilation, combined high frequency ventilation and airway pressure release ventilation on experimental lung injury

The effect of combined high frequency ventilation with and without continuous positive airway pressure in experimental lung injury

High frequency jet ventilation in experimental pulmonary emphysema

Contact Info

Product

Resources

About