Collecting Duct Renal Cell Carcinoma: A Matched Analysis of 41 Cases

Karakiewicz, Pierre I.; Trinh, Quoc‐Dien; Rioux‐Leclercq, Nathalie; Taille, A. De La; Novara, Giacomo; Tostain, Jacques; Cindolo, Luca; Ficarra, Vincenzo; Artibani, Walter; Schips, Luigi; Zigeuner, Richard; Mulders, Peter F.A.; Lechevallier, É.; Coulange, C.; Valéri, Antoine; Descotes, Jean‐Luc; Rambeaud, Jean‐Jacques; Abbou, C.C.; Lang, Hervé; Jacqmin, Didier; Méjean, A.; Patard, J.J.

doi:10.1016/j.eururo.2007.01.070

Cited by 101 publications

(72 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, 2 patients in our series had adrenal metastases, a site not commonly reported for cdc metastasis 3 . The poor prognosis reported in several series also held true for our patients, who had a median survival of 11 months [1][2][3] . Histopathology diagnosis of cdc in our series was complex and required specialized review.…”

Section: Case Seriesmentioning

confidence: 48%

“…Recently published series [1][2][3] and conventional secondary sources 9 do not provide direction on the appropriate management of cdc. It is for that purpose that we report the results of a systematic review addressing the management of cdc.…”

Section: Discussionmentioning

confidence: 99%

“…Localized cdc is an uncommon entity [1][2][3] . No studies encountered in our review addressed the management of localized cdc.…”

Section: Localized Cdcmentioning

confidence: 99%

“…Surgery Almost all reported patients with cdc have undergone surgery [1][2][3]11 and are diagnosed with cdc only after a histopathology examination. To illustrate this point, 87% of patients in the study by Oudard et al underwent prior cytoreductive nephrectomy.…”

Section: 21mentioning

confidence: 99%

See 3 more Smart Citations

Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience

et al. 2013

View full text Add to dashboard Cite

Introduction: Collecting duct carcinoma (CDC) is a rare, aggressive form of renal carcinoma that presents at an advanced stage and has a poor prognosis. Little is known concerning the optimal management of CDC. We present the results of a systematic review addressing the management of CDC and the McMaster University CDC series. Methods: The MEDLINE, Cochrane Library, and EMBASE databases and conference proceedings were searched to identify studies relating to the management of CDC. Included studies reported on a minimum of 10 subjects receiving a single intervention. Series in which an evaluation of therapeutic effectiveness was not possible were excluded. The McMaster University (Hamilton, Ontario) series of 6 cases of CDC were retrospectively reviewed. Results: We identified 3 studies relevant to the management of CDC that included a total of 72 patients. A gemcitabine–cisplatin or –carboplatin regimen resulted in a 26% objective response rate in 23 patients with metastatic CDC. Two additional studies indicated that 49 patients treated with immunotherapy achieved no response. In the McMaster series, cytoreductive nephrectomy was performed in 4 of 6 patients. In 2 patients, MVAC therapy (methotrexate–vinblastine–doxorubicin–cisplatin) achieved no response. No significant therapeutic complications occurred, but survival was poor (median: 11 months; range: 10–33 months). Conclusions: Our review and clinical experience suggest that the current standard of care for metastatic CDC is a gemcitabine–cisplatin regimen.

show abstract

Section: Case Seriesmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

“…Localized cdc is an uncommon entity [1][2][3] . No studies encountered in our review addressed the management of localized cdc.…”

Section: Localized Cdcmentioning

confidence: 99%

Section: 21mentioning

confidence: 99%

See 2 more Smart Citations

Management of Renal Collecting Duct Carcinoma: A Systematic Review and the McMaster Experience

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Karakiewicz reported that when CDC cases were compared to conventional RCC controls with the same pattern of symptoms, stage, and grade of disease, cause-specific survival was similar in both groups. 9 Pathologically, CDC consists of a tubular or tubulopapillary growth pattern with irregular angulated glands. Solid , cord-like patterns and sarcomatoid features may be seen.…”

Section: Discussionmentioning

confidence: 99%

Collecting duct carcinoma with acquired cystic disease of the kidney in a long‐term hemodialysis patient

et al. 2008

View full text Add to dashboard Cite

Abstract:We report a very rare case of collecting or Bellini duct carcinoma (CDC) found in a 60-year-old male who had received hemodialysis therapy for 21 years. Screening with ultrasonography revealed a solid tumor originating from the cyst wall in the right kidney with acquired cystic disease of the kidney. Subsequent computed tomography (CT) and angiography could not detect another renal tumor. Right radical nephrectomy was performed. The tumor detected preoperatively was composed of papillary renal cell tumor (RCC) and multiple clear cell carcinoma, pathologically. In addition to the tumors, CDC was revealed in the central medulla with the involvement of regional lymph nodes. Three months later, left nephrectomy was performed because left RCC was suspected during CT. The histological diagnosis was multiple clear cell carcinomas. Peritonitis carcinomatosa appeared and the patient died 13 months later.

show abstract