Collection of HSC in Children

Witt, Volker; Peters, Christina

doi:10.1007/978-3-030-02278-5_16

Cited by 2 publications

(5 citation statements)

References 26 publications

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“…15 We are interested in using analytics that employs "data-science techniques to make explicit the formal associations and affinities'' to identify signature characteristics in Atelier Bow-Wow's Pet Architecture sites. 16 Certain Measures is creating a catalog system much like a librarian would, while we are interested in creating something much more akin to a metal detector.…”

Section: Methodsmentioning

confidence: 99%

Pet Parcels

Imai,

Conway

2022

Empower

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This study combines the concepts from Gordon Matta- Clark’s “Fake Estates” with Certain Measures’s cartographic RoweBot, to create a mapping tool for finding and representing open lots within cities’ existing urban fabric. Referencing a lineage of urban theory by architects that spans from Colin Rowe and John Hejduk’s 1957 “Lockhart, Texas” to Atelier Bow-Wow’s 2001 Pet Architecture Guide Book, Pet Parcels proposes a historically conscious computational model for increasing cities’ density. Results from an analysis of Lubbock, Texas will be shared to articulate the methodology behind this approach. With potential application by city planning agencies, community stakeholders, and architectural practitioners, this digital design method seeks to provide a tool for translating found urban conditions into parameters for generating novel design interventions.

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Section: Methodsmentioning

confidence: 99%

Pet Parcels

Imai,

Conway

2022

Empower

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“…13,14 While PVC collections in older children and young adults have been reported, data in the pediatric population remains scarce and unlike in adult patients the use of PVCs is not routine practice. 3,5 The goal of this study was to determine if it is feasible and safe to utilize PVC access in a select pediatric population to reduce the need for CVC insertions. To the best of our knowledge, this is the first systematic approach to implement PVC collection in pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

“…The utilization of Hematopoietic Stem Cells (HSC) and Immune Effector Cells (IEC) in children continues to increase as both treatment outcomes have improved and indications for cellular products have expanded 1, 2 . HSCs are collected from children for autologous HSC transplantation (HSCT) following mobilizing chemotherapy, and from healthy sibling donors after growth factor stimulation for allogeneic HSCT 3 . The collection of IECs in children is currently used primarily for the cellular manufacturing of CAR T‐cells for the treatment of acute leukemias.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 HSCs are collected from children for autologous HSC transplantation (HSCT) following mobilizing chemotherapy, and from healthy sibling donors after growth factor stimulation for allogeneic HSCT. 3 The collection of IECs in children is currently used primarily for the cellular manufacturing of CAR T-cells for the treatment of acute leukemias. With further advances in cellular therapies 4 it is anticipated that the use of HSCs and IECs in children will continue to expand and strategies to improve the collection of these cellular products are important to optimize clinical care.…”

Section: Introductionmentioning

confidence: 99%

“…However, CVCs are associated with additional procedural risks including pain, infection, anesthetic, bleeding, thromboses, and resource utilization such as equipment, interventional radiology expertise, operating room, and anesthesia time 13, 14 . While PVC collections in older children and young adults have been reported, data in the pediatric population remains scarce and unlike in adult patients the use of PVCs is not routine practice 3, 5 …”

Section: Introductionmentioning

confidence: 99%

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Peripheral venous catheter collection of immune effector cells and hematopoietic stem cells is feasible and safe in older pediatric patients

et al. 2021

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Background: The Collection of hematopoietic stem cells (HSC) and immune effector cells (IEC) has unique challenges in children. To maintain adequate blood flow, central venous catheters (CVCs) remain the standard of care in many centers, but are associated with procedural risks and increased resource utilization. The goal of this study was to determine feasibility and safety of peripheral venous catheter (PVC) cell collection in older children.Methods: Patients and donors requiring venous access with weight >25 kg, age >8 years were screened for PVC collection via 18G PVCs. Those with poor venous access (on history/exam/pre-screening ultrasound) or unable to maintain suitable procedural position were excluded. Comparison was made to CVC collections in a matched patient cohort.Results: Thirty-eight individuals were screened and met age/weight criteria for PVC collection. Five did not have PVC collection attempted due to poor access (n = 4) or behavioral concerns (n = 1). Thirty-three had PVC collection attempt (HSC = 22; IEC = 11) with median age 15.3 year (range 9.7-18.0) and weight 58.5 kg (range 27.9-115.4). Thirty-two of 33 (97%) patients were collected successfully by PVC without adverse events. Comparing PVC to matched CVC collection cohort (n = 18), there was no significant difference in flow rate (48.2 mL/h vs 53.9 mL/h, p = 0.12), collection time (266 min vs 262 min, p = 0.85) or collection efficiency (IEC/CD3 60.9% vs 60.8% p = 0.99; HSC/CD34 53.6% vs 41.3% p = 0.05). Conclusion: PVC collection of HSC and IEC is feasible and safe in older children with comparable collection efficiency to CVC collections. Ultrasound screening may reduce failure rates. PVC collections can reduce the risk of CVC insertions and associated healthcare costs.

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Collection of HSC in Children

Cited by 2 publications

References 26 publications

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Pet Parcels

Peripheral venous catheter collection of immune effector cells and hematopoietic stem cells is feasible and safe in older pediatric patients

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