Collective cell migration in development

Scarpa, Elena; Mayor, Roberto

doi:10.1084/jem.2132oia3

Cited by 46 publications

(70 citation statements)

References 79 publications

(138 reference statements)

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“…A key feature to emerge from these studies of diverse species is the similarity in the patterns of expansion of the three NCr streams (reviewed by: Falck et al, 2002). Within each stream NCr cells show tight coherence as the population expands ventrally and rostrally, a process described as collective cell behavior (reviewed by: Carmona-Fontaine et al, 2008;Scarpa & Mayor, 2016;Theveneau & Mayor, 2012;Wynn, Rupp, Trainor, Schnell, & Kulesa, 2014). Establishing and maintaining these compact streams is facilitated through a complex set of interactions both among NCr cells (Barriga et al, 2018;Gunuth et al, 2018;Kulesa & Fraser, 2000;McKeown, Wallace, & Anderson, 2013) and with their neighbors.…”

Section: E M E R G E N C E An D S P Re a D O F C R A N I O Fa C I Amentioning

confidence: 99%

Neural crest and the patterning of vertebrate craniofacial muscles

Ziermann

Diogo

Noden

2018

Genesis

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Patterning of craniofacial muscles overtly begins with the activation of lineage-specific markers at precise, evolutionarily conserved locations within prechordal, lateral, and both unsegmented and somitic paraxial mesoderm populations. Although these initial programming events occur without influence of neural crest cells, the subsequent movements and differentiation stages of most head muscles are neural crest-dependent. Incorporating both descriptive and experimental studies, this review examines each stage of myogenesis up through the formation of attachments to their skeletal partners. We present the similarities among developing muscle groups, including comparisons with trunk myogenesis, but emphasize the morphogenetic processes that are unique to each group and sometimes subsets of muscles within a group. These groups include branchial (pharyngeal) arches, which encompass both those with clear homologues in all vertebrate classes and those unique to one, for example, mammalian facial muscles, and also extraocular, laryngeal, tongue, and neck muscles. The presence of several distinct processes underlying neural crest:myoblast/myocyte interactions and behaviors is not surprising, given the wide range of both quantitative and qualitative variations in craniofacial muscle organization achieved during vertebrate evolution.

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Section: E M E R G E N C E An D S P Re a D O F C R A N I O Fa C I Amentioning

confidence: 99%

Neural crest and the patterning of vertebrate craniofacial muscles

Ziermann

Diogo

Noden

2018

Genesis

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“…For instance, during embryonic development, neural crest cells undergoing a partial or complete EMT can migrate as either a multicellular stream or individually, in order to reach distant tissues. Similarly, during gastrulation, both these modes of migration are observed at different spatiotemporal coordinates (Scarpa and Mayor, 2016). Typically, collective migration is associated with a partial EMT or hybrid E/M phenotype (Kuriyama et al, 2014;Sarioglu et al, 2015), whereas fully mesenchymal cells tend to migrate alone.…”

Section: How Can Mathematical Models Be Used To Study Changes In Othementioning

confidence: 99%

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

et al. 2017

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Phenotypic plasticity, the ability of cells to reversibly alter their phenotypes in response to signals, presents a significant clinical challenge to treating solid tumors. Tumor cells utilize phenotypic plasticity to evade therapies, metastasize, and colonize distant organs. As a result, phenotypic plasticity can accelerate tumor progression. A well‐studied example of phenotypic plasticity is the bidirectional conversions among epithelial, mesenchymal, and hybrid epithelial/mesenchymal (E/M) phenotype(s). These conversions can alter a repertoire of cellular traits associated with multiple hallmarks of cancer, such as metabolism, immune evasion, invasion, and metastasis. To tackle the complexity and heterogeneity of these transitions, mathematical models have been developed that seek to capture the experimentally verified molecular mechanisms and act as ‘hypothesis‐generating machines’. Here, we discuss how these quantitative mathematical models have helped us explain existing experimental data, guided further experiments, and provided an improved conceptual framework for understanding how multiple intracellular and extracellular signals can drive E/M plasticity at both the single‐cell and population levels. We also discuss the implications of this plasticity in driving multiple aggressive facets of tumor progression.

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“…Recent works have shown that Rac is first activated in some epithelial cells of the free borders during the collective cell migration, which leads to Rac activation in the rest of the cells as well as to the formation of lamellipodia in free border cells and small cryptic lamellipodia in cells located in the center of the epithelial sheet (Lebreton & Casanova, 2014;Scarpa & Mayor, 2016). Therefore, the polarized distribution of CD cells expressing Rac1 within the colony following BK stimulation seems to correlate to the distribution of the active Rac form in epithelial cell sheets, described by the aforementioned authors.…”

Section: Discussionmentioning

confidence: 99%

Bradykinin mediates the association of collecting duct cells to form migratory colonies, through B2 receptor activation

Guaytima

Brandán

Favale

et al. 2018

Journal Cellular Physiology

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It is known that bradykinin (BK) B2 receptor (B2R) is expressed in the collecting duct (CD) cells of the newborn rat kidney, but little is known about its role during early postnatal life. Therefore, we hypothesize that BK could participate in the mechanisms that mediate CD formation during the postnatal renal development. Performing primary cultures, combined with biochemical, immunocytochemical, and time-lapse analysis, we studied the role of BK in CD cell behavior isolated from renal papilla of neonatal rats. A reverse relationship was observed between B2R expression and the degree of CD epithelial cell sheet maturation. BK stimulation induced CD cell association upon B2R activation. The lack of B2R expression in cells showing mature adherens junctions suggested that BK is mostly involved in early adhesive events, thus favoring the initial formation of CD during development. Time-lapse analysis revealed that BK induced a high protrusive activity of CD cells, denoted by ruffle formation and lamellipodia extension. PI3K was involved in the BK-induced CD cell-cell association and the acquisition of the migratory phenotype since, when inhibited, membrane ruffles, and filopodia between cells diminished. Results indicate that the actions of BK mediated by PI3K activation were due to the downstream Akt and Rac pathways. This study, performed with CD cells that were not genetically manipulated, provides new experimental evidence supporting a novel role of BK in rat renal CD organization. As B2R blockade results in abnormal tubular differentiation, our results contribute to better understanding the etiology of human congenital renal malformation and diseases.

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Collective cell migration in development

Cited by 46 publications

References 79 publications

Neural crest and the patterning of vertebrate craniofacial muscles

Neural crest and the patterning of vertebrate craniofacial muscles

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

Bradykinin mediates the association of collecting duct cells to form migratory colonies, through B2 receptor activation

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