2009
DOI: 10.1038/nrm2720
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Collective cell migration in morphogenesis, regeneration and cancer

Abstract: The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such migration, cells move as sheets, strands, clusters or ducts rather than individually, and use similar actin- and myosin-mediated protrusions and guidance by extrinsic chemotactic and mechanical cues as used by single migratory cells. However, cadherin-based junctions between cells additionally maintain 'supracellular' properties, s… Show more

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Cited by 2,355 publications
(2,301 citation statements)
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References 126 publications
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“…Discussion E-cadherin is known to suppress tumor cell growth and invasion, and re-expression of E-cadherin in E-cadherindeficient carcinomas reverts cells to a less invasive, less aggressive phenotype (St Croix et al, 1998;Gottardi et al, 2001;Yanagisawa and Anastasiadis, 2006;Soto et al, 2008). On the other hand, the expression of E-cadherin supports cohesive, collective cell migration/ invasion (Friedl and Gilmour, 2009). Although the loss of E-cadherin expression or function is a common event in tumor progression (Yap, 1998;Nollet et al, 1999), there is emerging evidence that the expression of E-cadherin during cancer progression may be dynamic and highly contextual (Kowalski et al, 2003).…”
Section: Regulation Of Pten Levels By Cell Density and E-cadherin-cadmentioning
confidence: 98%
“…Discussion E-cadherin is known to suppress tumor cell growth and invasion, and re-expression of E-cadherin in E-cadherindeficient carcinomas reverts cells to a less invasive, less aggressive phenotype (St Croix et al, 1998;Gottardi et al, 2001;Yanagisawa and Anastasiadis, 2006;Soto et al, 2008). On the other hand, the expression of E-cadherin supports cohesive, collective cell migration/ invasion (Friedl and Gilmour, 2009). Although the loss of E-cadherin expression or function is a common event in tumor progression (Yap, 1998;Nollet et al, 1999), there is emerging evidence that the expression of E-cadherin during cancer progression may be dynamic and highly contextual (Kowalski et al, 2003).…”
Section: Regulation Of Pten Levels By Cell Density and E-cadherin-cadmentioning
confidence: 98%
“…The rate of invasion of the single-cell process, in vitro and in vivo, is much faster than the progression in bulk (Alexander et al, 2008;Friedl and Gilmour, 2009). There are two major types of single-cell movements: through the matrix, as in bulk progression, with digestion of the matrix upfront and its re-synthesis after passage and amoeboid movement around and in between the matrix.…”
Section: Breaking Barriers: Cancer Invasion Metastasis and Cell Metamentioning
confidence: 99%
“…Although key aspects of single cell migration such as the control of protrusive activity, shape generation and interaction between the cell and the extra cellular matrix (ECM) are fairly well understood (Friedl and Gilmour 2009), the mechanisms that regulate collective cell migration are less clear.…”
Section: Introductionmentioning
confidence: 99%
“…While in the former case cells move together in a manner similar to that of single cells, in the latter case cells remain linked both physically and functionally during the movement (Friedl and Gilmour 2009). Cellcell junctions are maintained through adherens junctions proteins, desmosomal proteins, and integrins (Friedl and Gilmour 2009;Ilina and Friedl 2009), which prevent the formation of gaps between the cells (Anand et al 2007). These interactions limit the movement of the cells within the layer and restrict any cellular rearrangement.…”
Section: Introductionmentioning
confidence: 99%
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