Collective cell migration patterns: Follow the leader

Gov, Nir S.

doi:10.1073/pnas.0708037104

Cited by 60 publications

(53 citation statements)

References 14 publications

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“…While it was originally suspected that leader cells might speed up wound closure [102] and that they are responsible for dragging the cell sheet behind them by excreting traction forces on the substrate ( [32,85,[102][103][104]), Trepat et al mapped these forces throughout the cell sheet and showed that the leader cells' contribution to the overall force balance is small. Instead, traction forces of similar magnitude can arise throughout the cell sheet.…”

Section: Leader Cells and Roughening Of The Epithelial Bordermentioning

confidence: 99%

Phenomenological approaches to collective behavior in epithelial cell migration

Zorn

Marel

Segerer

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Collective cell migration in epithelial tissues resembles fluid-like behavior in time-lapse recordings. In the last years, hydrodynamic velocity fields in living matter have been studied intensely. The emergent properties were remarkably similar to phenomena known from active soft matter systems. Here, we review migration experiments of large cellular ensembles as well as of mesoscopic cohorts in micro-structured environments. Concepts such as diffusion, velocity correlations, swirl strength and polarization are metrics to quantify the cellular dynamics both in experiments as well as in computational simulations. We discuss challenges relating collective migration to single cell and oligocellular behavior as well as linking the phenotypic parameters to the underlying cytoskeleton dynamics and signaling networks. This article is part of a Special Issue entitled: Mechanobiology.

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Section: Leader Cells and Roughening Of The Epithelial Bordermentioning

confidence: 99%

Phenomenological approaches to collective behavior in epithelial cell migration

Zorn

Marel

Segerer

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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“…In addition to growth factors, a multitude of chemical signals is produced when a wound occurs [31]. Injury and its associated tissue damage would result in the release of cellular proteins that, through receptors on the surface of surrounding cells, provoke a very complex response intended to close, and eventually heal, the wound [31].…”

Section: Egfr Transactivation Growth Factor Cross-talk and The Comentioning

confidence: 99%

Growth factors and corneal epithelial wound healing

Yin

et al. 2010

Brain Research Bulletin

174

117

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“…The resurfacing of an epidermal wound by migrating keratinocytes was initially described by the term of leapfrogging cells that progressively fall over each other and onto the wound bed without certain migrational activity [25,26]. Other authors depicted leader cells or even entire cell rows that drag others with them to crawl over the wound [27,28,29,30]. Additionally, 3 other mechanisms might also be involved such as extension membrane or epidermal tongue, lamellipodial crawling and shuffling [31,32].…”

Section: Epithelialization In Skin Wound Healingmentioning

confidence: 99%

Skin Wound Healing: An Update on the Current Knowledge and Concepts

Sorg

Tilkorn²,

Hager³

et al. 2016

Eur Surg Res

951

691

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Background: The integrity of healthy skin plays a crucial role in maintaining physiological homeostasis of the human body. The skin is the largest organ system of the body. As such, it plays pivotal roles in the protection against mechanical forces and infections, fluid imbalance, and thermal dysregulation. At the same time, it allows for flexibility to enable joint function in some areas of the body and more rigid fixation to hinder shifting of the palm or foot sole. Many instances lead to inadequate wound healing which necessitates medical intervention. Chronic conditions such as diabetes mellitus or peripheral vascular disease can lead to impaired wound healing. Acute trauma such as degloving or large-scale thermal injuries are followed by a loss of skin organ function rendering the organism vulnerable to infections, thermal dysregulation, and fluid loss. Methods: For this update article, we have reviewed the actual literature on skin wound healing purposes focusing on the main phases of wound healing, i.e., inflammation, proliferation, epithelialization, angiogenesis, remodeling, and scarring. Results: The reader will get briefed on new insights and up-to-date concepts in skin wound healing. The macrophage as a key player in the inflammatory phase will be highlighted. During the epithelialization process, we will present the different concepts of how the wound will get closed, e.g., leapfrogging, lamellipodial crawling, shuffling, and the stem cell niche. The neovascularization represents an essential component in wound healing due to its fundamental impact from the very beginning after skin injury until the end of the wound remodeling. Here, the distinct pattern of the neovascularization process and the special new functions of the pericyte will be underscored. At the end, this update will present 3 topics of high interest in skin wound healing issues, dealing with scarring, tissue engineering, and plasma application. Conclusion: Although wound healing mechanisms and specific cell functions in wound repair have been delineated in part, many underlying pathophysiological processes are still unknown. The purpose of the following update on skin wound healing is to focus on the different phases and to brief the reader on the current knowledge and new insights. Skin wound healing is a complex process, which is dependent on many cell types and mediators interacting in a highly sophisticated temporal sequence. Although some interactions during the healing process are crucial, redundancy is high and other cells or mediators can adopt functions or signaling without major complications.

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Collective cell migration patterns: Follow the leader

Cited by 60 publications

References 14 publications

Phenomenological approaches to collective behavior in epithelial cell migration

Phenomenological approaches to collective behavior in epithelial cell migration

Growth factors and corneal epithelial wound healing

Skin Wound Healing: An Update on the Current Knowledge and Concepts

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