Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

Abstract

The collective migration of cells is a complex integrated process that represents a common theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a remarkable amount of secondary metabolites produced by aquatic invertebrates displays active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of crude extracts or isolated compounds that exert a modulatory effect on collective cell locomotion and/or skin tissue reconstitution and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated to the substances under examination, grouping the producing species according to their taxonomic hierarchy. Taken all of the collected data into account, marine invertebrates emerge as a still poorly-exploited valuable resource of natural products that may significantly improve the process of skin regeneration and restrain tumor cell migration, as documented by in vitro and in vivo studies. Therefore, the identification of the most promising invertebrate-derived extracts/molecules for the utilization as new targets for biomedical translation merits further and more detailed investigations.

MIR31 May Mediate Multiple Biology Processes To Promote Vocal Fold Wound Healing

“…Collagen has been shown to increase keratinocyte proliferation, positively acting on cell entry in the mitotic phase (Luparello et al, 2020). Thus, collagen synthesis and deposition into the wound is essential during wound healing (Han et al, 2012).…”

Marine Animal-Derived Compounds and Autophagy Modulation in Breast Cancer Cells

“…Thus, to cite just a few examples, anticancer compounds have been found among the primary and secondary metabolites of starfishes and Mediterranean ascidians [20,21], and extracts or isolated molecules obtained from marine invertebrates have been proven to exert a modulatory effect on collective cell migration, a process at the basis of different biological events such as neoplastic cell metastasization and wound repair [22]. Chemicals with histone deacetylase inhibitory properties, whose wide range of potential biomedical applications is generally acknowledged, have also been extracted and identified in preparations from marine invertebrates [23].…”

“…They show a relatively smooth surface with several pores and can be found as encrusting species growing over coral rubbles [29]. In 2013, Yamazaki et al [30] reported the cytotoxic activity of the pentacyclic alkaloid papuamine (1S,2E,4E,6S,7R,12S,14R,20R,22S,27R)-15,19diazapentacyclo[18.7.0.0 6,14 .0 7,12 .0 22,27 ]heptacosa-2,4-diene, Figure 1), the major constituent of these sponges, in MCF-7 breast cancer cells.…”

“…They show a relatively smooth surface with several pores and can be found as encrusting species growing over coral rubbles [29]. In 2013, Yamazaki et al [30] reported the cytotoxic activity of the pentacyclic alkaloid papuamine (1S,2E,4E,6S,7R,12S,14R,20R,22S,27R)-15,19-diazapentacyclo[18.7.0.0 6,14 .0 7,12 .0 22,27 ]heptacosa-2,4-diene, Figure 1), the major constituent of these sponges, in MCF-7 breast cancer cells. A more detailed molecular examination of the effect exerted on MCF-7 cells by the alkaloid at concentrations at or greater than 5 µM demonstrated the expression of LC3, a central component of the autophagy process, as revealed by confocal microscopic observations of the time-dependent increase of LC3-associated fluorescence intensity from 4 h of exposure onward.…”

Histone Deacetylase Inhibitors from Marine Invertebrates

“…These products contribute to the adaptation mechanisms to the specific life conditions in the greatly different marine ecosystems [26]. A large proportion of invertebrate-derived extracts and isolated compounds has shown active pharmacological properties, such as anticancer, antimicrobial, and anti-inflammatory, among others, with an extensive spectrum of biomedical applications that makes them already approved or prospective drugs of marine origin with promising results for different therapeutic purposes [27][28][29][30][31][32]. Within this scenario, the aim of this review is to gather selected studies that reported the extraction and identification of marine invertebrate-derived chemicals that possess HDACi properties and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated with the examined molecules.…”