“…Currently in the noisy intermediate-scale quantum (NISQ) era [1], digital quantum devices available for scientific applications have modest numbers of physical qubits, limited but improving fidelity, noisy gate operations, and short coherence times. Device noise in current simulations is mitigated to some degree by selecting a configuration with the highest-fidelity qubits and desired entangling gates within a given quantum processing unit; extrapolating entangling gate errors with global controlled-NOT replacement [2][3][4][5][6][7][8][9][10][11][12][13][14][15] and local stochastic insertions [16,17]; postselection of physical subspaces [16,18]; addressing measurement errors through inversion of simple noise models [19], classical conditional probabilities [20], and majority voting [12]; and time-dependent in vivo calibration work flows and in-medium gate correction [8]. Excitingly, first steps toward experimental demonstration of quantum error correction (QEC) have emerged, e.g., recent demonstrations of exponential convergence of the repetition code [21][22][23][24], error detection in the surface code [25][26][27][28][29][30] on the 53-qubit Sycamore superconducting processor [23,31], fault-tolerant operations in the nine-qubit Bacon-Shor code on 13 trapped 171 Yb + ions [24], and real-time error correction in the [7,1,…”