College of Physicians of Philadelphia

Repeated urinary calculi developed in a patient who was treated with methazolamide for glaucoma. Previously, he had developed calculi while receiving acetazolamide.The factors involved in urinary calculus formation with carbonic anhydra,~e inhibitor therapy are reviewed. It appears that the incidence of calculus formation is less with methazolamide than with acetazolamide, and patients may be free of urinary symptoms when switched from acetazolamide to methazolamide therapy. It is suggested that the incidence of calculus formation in patients on any carbonic anhydrase inhibitor therapy may be reduced by increasing urine output, restricting calcium in diet, and by the use of aluminum hydroxide gel, oral sodium and potassium phosphates or hydrochlorothiazide.Urinary calculus formation as a complication of acetazolamide (Diamox) therapy is well-documented in clinical and experimental studies.Because methazolamide (Neptazane) is a more potent carbonic anhydrase inhibitor than acetazolamide on a weight basis with smaller dosages required, this drug has been tried in the treatment of glaucoma patients who could not From:

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�ber den Einfluss des Carboanhydrasehemmstoffes 2-Acetylamino-1,3,4-Thiadiazol-5-Sulfonamid (Acetazolamid) auf die Citronens�ureausscheidung im Harn

Otto

1958

Klin Wochenschr

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College of Physicians of Philadelphia

Cited by 7 publications

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Carbonic Anhydrase: Pharmacology of Inhibitors and Treatment of Glaucoma

Carbonic Anhydrase: Pharmacology of Inhibitors and Treatment of Glaucoma

Urinary calculi with methazolamide therapy

�ber den Einfluss des Carboanhydrasehemmstoffes 2-Acetylamino-1,3,4-Thiadiazol-5-Sulfonamid (Acetazolamid) auf die Citronens�ureausscheidung im Harn

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