Collision carcinoma of squamous cell carcinoma and small cell neuroendocrine carcinoma of the larynx: A case report and review of the literature

Abstract

BACKGROUNDCollision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment.CASE SUMMARYA 61-year-old man presented with a 1-year history of hoarseness. Contrast-enhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO2 laser (Vc type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was found.CONCLUSIONThe treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.

Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report

“…Collision tumor refers to two malignant tumors coexisting and the components originate from the same area or organ but with different morphologies according to histologic examination. There are various theories related to collision tumors; however, due to low frequency and individuality, controversy still exists regarding the pathogenesis and definition (8). Reports on the synchronous and metachronous coexistence of SmCC and SCC in the same anatomic space in the head and neck are rare.…”

“…Most cases of SmCC in the head and neck extend into adjacent spaces without extensive bone destruction (3). A previous study reported on SmCC of the nasal cavity with extensive and aggressive destruction of bone at the skull base and invasion of the right orbit (8).…”

Collision carcinoma of the rectum involving neuroendocrine carcinoma and adenocarcinoma: A case report

“…The highest incidence is seen in developed countries. In recent years, the incidence has increased rapidly and younger patients in developing countries have been identified[ 5 ]. The most important risk factor is genetic predisposition depending on the type of mutation, in addition, red meat, alcohol, smoking and excess body fat are also risk factors.…”

Oral collision cancer: A case report and literature review of simultaneous squamous cell and adenoid cystic carcinoma of the oral mucosa

“…1,2 Collision carcinomas have been described in various organs including the cranium, lungs, stomach, larynx, and thyroid gland [3][4][5][6][7] with several cases reported in the head and neck but very rarely in the oral mucosa (Table 1). [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Indeed, and to the best of our knowledge, only two cases of oral collision cancer have been reported (Table 1: Cases 1 and 4). More specifically, Takeda et al 8 describe a collision between duct carcinoma and SqCC in the lip, while Falanga et al 11 report a collision cancer between desmoplastic melanoma and SqCC occurring in the mouth floor.…”