Collision of Commonality and Personalization: Better Understanding of the Periosteum

Tang, Yufei; Wu, Bingfeng; Huang, Tianyu; Wang, Haochen; Shi, Ruijianghan; Wei, Lai; Lin, Xiang

doi:10.1089/ten.teb.2022.0076

Cited by 3 publications

(4 citation statements)

References 119 publications

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“…It was speculated that the posterior cortex had less periosteum (necessary for bone tissue growth) and soft tissue destruction during osteotomy. The periosteum has three layers of structure: the superficial fibrous layer, the middle vascular undifferentiated area, and the inner cambium layer, which is adjacent to the outer surface of the bone with decent osteogenic ability (28,29). Importantly, the callus formation was significantly impaired (failed bone TABLE 5 The associations of early PVR in four cortices with the healing index, lengthening index, and external fixator index in bone union.…”

Section: Discussionmentioning

confidence: 99%

The early posterior cortex pixel value ratio: a novel reliable indicator for distraction osteogenesis

Liu,

Wang

et al. 2023

Front. Surg.

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AimsWe aimed to explore the associations of the early PVR in four cortices with Healing Index (HI), Lengthening Index (LI), and External Fixator Index (EFI) in the bone union and non-union groups.MethodsA total of 52 patients, including 39 bone union and 13 bone non-union subjects, were recruited in this study. The general characteristics and PVR in four cortices in each group were explored. Afterward, the early PVR in four cortices, including medial, lateral, anterior, and posterior sides, were compared. Finally, the associations of the early PVR in four cortices with HI, LI, and EFI were also investigated.ResultsThe general characteristics of these patients were consistent, except for HI (31.54 ± 12.24 vs. 45.08 ± 27.10, P = 0.018) and EFI (57.63 ± 18.15 vs. 71.29 ± 24.60, P = 0.046). The growth of regenerated callus was asymmetrical in the bone union group (the posterior PVR seems to grow faster), whereas no statistical difference was obtained in the bone non-union group. Furthermore, the posterior PVR in the bone union group was significantly higher than that in the bone non-union group (the first month: 0.96 ± 0.17 vs. 0.86 ± 0.06, p = 0.047; the second month: 0.98 ± 0.14 vs. 0.89 ± 0.09, p = 0.041; the third month: 1.00 ± 0.12 vs. 0.92 ± 0.09, p = 0.039). Most importantly, the posterior PVR was inversely associated with HI, LI, and EFI (the first month: r = −0.343, p = 0.041; r = −0.346, p = 0.042; r = −0.352, p = 0.041; the second month: r = −0.459, p = 0.004; r = −0.277, p = 0.101; r = −0.511, p = 0.002; the third month: r = −0.479, p = 0.003; r = −0.398, p = 0.018; r = −0.551, p = 0.001) in the bone union group, respectively. However, this finding was lost in the bone non-union group.ConclusionThe early posterior cortex PVR seems to grow faster than the medial, lateral, and anterior sides in the bone union group, which represents an asymmetrical development pattern. Moreover, the posterior cortex PVR was negatively associated with HI, LI, and EFI, respectively. The posterior cortex PVR may be a novel and reliable detection index in the process of DO.

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Section: Discussionmentioning

confidence: 99%

The early posterior cortex pixel value ratio: a novel reliable indicator for distraction osteogenesis

Liu,

Wang

et al. 2023

Front. Surg.

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“…In addition to traditional bone regeneration, the UVmediated in situ hydrogel is combined with an autologous bone grafting technique to improve osseointegration and bone fusion. For example, Wu et al (Wu H. et al, 2023) initiated a new method to mend the gaps between osteochondral plugs after mosaicplasty. This approach employs an injectable photosensitive hydrogel (BSN-GelMA), which is fabricated by GelMA loaded with bioactive supramolecular nanofibers to mimic IGF-1(IGF-1bsn) that can bind to IGF-1 receptors and improve the bioavailability, due to their high stability and tissue retention.…”

Section: Uv Light Crosslinking To In Situ Hydrogelmentioning

confidence: 99%

Section: Uv Light Crosslinking To In Situ Hydrogelmentioning

confidence: 99%

“…The periosteum is made up of fibrous connective tissue, which is rich in nerves and blood vessels and plays a vital role in bone nutrition, regeneration, and sensation ( Caffarelli et al, 2023 ). Sclerotin is a hierarchical and anisotropic structure, which is mainly composed of dense cortical bone and spongy cancellous bone ( Delawan et al, 2023 ; Tang et al, 2023 ). The dense cortical bone possesses high mechanical strength and encompasses the cancellous bone on the periphery, which possesses an excellent stabilizing and supporting function.…”

Section: Bone Tissue Structure and Bone Tissue Microenvironmentmentioning

confidence: 99%

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Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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Identification of Postn+ periosteal progenitor cells with bone regenerative potential

Yin,

Shen,

et al. 2024

JCI Insight

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Bone contains multiple pools of skeletal stem/progenitor cells (SSPCs), and SSPCs in periosteal compartments are known to exhibit higher regenerative potential than those in BM and endosteal compartments. However, the in vivo identity and hierarchical relationships of periosteal SSPCs (P-SSPCs) remain unclear due to a lack of reliable markers to distinguish BM SSPCs and P-SSPCs. Here, we found that periosteal mesenchymal progenitor cells (P-MPs) in periosteum can be identified based on Postn -CreER T2 expression. Postn -expressing periosteal subpopulation produces osteolineage descendants that fuel bones to maintain homeostasis and support regeneration. Notably, Postn + P-MPs are likely derived from Gli1 + skeletal stem cells (SSCs). Ablation of Postn + cells results in impairments in homeostatic cortical bone architecture and defects in fracture repair. Genetic deletion of Igf1r in Postn + cells dampens bone fracture healing. In summary, our study provides a mechanistic understanding of bone regeneration through the regulation of region-specific Postn + P-MPs.

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Collision of Commonality and Personalization: Better Understanding of the Periosteum

Cited by 3 publications

References 119 publications

The early posterior cortex pixel value ratio: a novel reliable indicator for distraction osteogenesis

The early posterior cortex pixel value ratio: a novel reliable indicator for distraction osteogenesis

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Identification of Postn+ periosteal progenitor cells with bone regenerative potential

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