Collision of Lymphoepithelioma-like Carcinoma with Diffuse Large B-cell Lymphoma of the Stomach: A Case Report

Liu, Liyan; Zhao, Huishan; Lin, Senjie; Yang, Ping; Zhou, Huihui; Wang, Ruizheng

doi:10.21873/anticanres.11855

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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“…Furthermore, due to the minimal size of the adenocarcinoma component and a lack of continuity with the SCNEC component, we conducted immunohistochemistry for confirmation. This was to exclude the possibility of a collision tumor, a rare confluence of adenocarcinoma and malignant lymphoma, as described in the literature (6,7). Keratins, also known previously as cytokeratins, are intermediate filamentforming proteins that constitute the primary cytoskeletal components of epithelial cells (8).…”

Section: Discussionmentioning

confidence: 99%

Gastric Small Cell Neuroendocrine Carcinoma With Loss of Epithelial Markers Expression

YAMADA,

UMEMOTO,

YONEMITSU

et al. 2024

CDP

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Background/Aim: Given that gastric small cell neuroendocrine carcinoma (SCNEC) is notably more aggressive than conventional adenocarcinoma, and a platinum-based regimen aligned with the treatment for pulmonary SCNEC is advocated when chemotherapy is needed, ensuring an accurate pathological diagnosis is paramount. Case Report: A 63-year-old man, examined for melena, underwent gastroscopy which revealed a total circumferential Borrmann type 3 lesion extending from the pylorus to the antrum of the stomach. He underwent a distal gastrectomy with D2 lymphadenectomy. The microscopic examination revealed SCNEC with a minor adenocarcinoma component. Immunohistochemically, the SCNEC was diffusely positive for synaptophysin, CD56, and INSM1, very focally positive for chromogranin A, and negative for leukocyte common antigen, CD3, and CD20. A significant observation in this case was the complete negativity for epithelial markers including keratin (CK7, CK8, CK20, CAM5.2, and AE1/AE3) and epithelial membrane antigen. Conclusion: Diffuse positivity for neuroendocrine markers, negativity for other lineage markers, and a transition from the adenocarcinoma component, if present, serve as significant diagnostic clues for gastric SCNEC with loss of epithelial markers expression. SCNEC should not be excluded solely based on the negative result for epithelial markers.

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“…An undifferentiated nasopharyngeal carcinoma, which was characterized by epithelial neoplastic cells developing in solid or incohesive sheets mixed with a noticeable lymphoid infiltration, was first named lymphoepithelioma by Carbone in 1982 [ 9 ]. LELC had similar histological features with lymphoepithelioma but primarily occurred in other organs, such as the esophagus [ 3 ], thymus [ 4 ], lungs [ 5 ], stomach [ 6 ], and liver [ 7 ]. LELC in the urinary system is rare, most common in the bladder, followed by the renal pelvis [ 10 ], ureter [ 11 ], and urethra [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lymphoepithelioma-like carcinoma (LELC) or lymphoepithelioma carcinoma is a rare malignant epithelial tumor characterized by lymphocytic interstitial hyperplasia [ 1 ]. It is most common in the nasopharynx [ 2 ], followed by the esophagus [ 3 ], thymus [ 4 ], lungs [ 5 ], stomach [ 6 ], and liver [ 7 ]. Primary LELC of the urinary system is rare.…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Lymphoepithelioma-Like Carcinoma of the Bladder With Review

Zheng¹,

Yu²,

Du³

et al. 2023

Cureus

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Lymphoepithelioma-like carcinoma (LELC) was characterized by epithelial neoplastic cells developing in solid or incohesive sheets mixed with a noticeable lymphoid infiltration. Lymphoepithelioma-like carcinoma of the bladder (LELCB), which was first described by Zukerberg, is a rare variant of LELC. Here we reported a new case of LELCB occurring in a 70-year-old woman presenting with hematuria. Computed tomography (CT) and cystoscopy revealed a tumor on the left upper wall of the bladder. A partial cystectomy was finally performed. Pathological and immunohistochemical analysis revealed LELCB. After receiving systemic adjuvant chemotherapy, the patient conducted a 25-month follow-up without experiencing a recurrence.

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Collision of Lymphoepithelioma-like Carcinoma with Diffuse Large B-cell Lymphoma of the Stomach: A Case Report

Abstract: This is the first report of collision of EBV-associated LELC with primary DLBCL of the stomach.

Cited by 5 publications

References 12 publications

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Gastric Small Cell Neuroendocrine Carcinoma With Loss of Epithelial Markers Expression

A Case of Primary Lymphoepithelioma-Like Carcinoma of the Bladder With Review

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