Collision of Two Tumors: A Case Report of a Lung Adenocarcinoma With Metastasis to a Pituitary Adenoma

Borhan, Marisa Khatijah; Tan, Francis Chee Kuan; Basry, Nur Shazwaniza Awang

doi:10.15605/jafes.037.02.09

Cited by 2 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collision tumors can happen in a variety of organs, such as the stomach, kidney, and pituitary [1][2][3]. In the central nervous system (CNS), meningioma tends to be one of the most common component of collision tumors (as recipient tumor), which also include pituitary adenoma and schwannoma [3,4]. The other component is often malignant tumors, like glioblastoma, breast cancer, lung cancer, and so on.…”

Section: Introductionmentioning

confidence: 99%

“…The most common type of collision tumor is tumor-to-tumor metastasis, which is the type discussed here. Collision tumors can happen in a variety of organs, such as the stomach, kidney, and pituitary [1][2][3]. In the central nervous system (CNS), meningioma tends to be one of the most common component of collision tumors (as recipient tumor), which also include pituitary adenoma and schwannoma [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease

Luo,

Sun,

2023

Case Rep Oncol

View full text Add to dashboard Cite

Collision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). Hemangioblastoma is rarely located in a supratentorial location, and intracranial lateral ventricular is also not a common site of metastasis for RCC. It is extremely rare for the two tumors to collide in the supratentorial area. We report a 64-year-old man with a history of clear cell RCC who presented with a sudden headache. The brain magnetic resonance imaging revealed that there was a cystic-solid mass in the intracranial lateral ventricular trigone. Histopathologically, the tumor consisted of two distinct components, most of which showed the typical morphology of hemangioblastoma. However, there were a few acinar structures composed of clear cells scattered in hemangioblastoma, and these acinar structures were subsequently confirmed as clear cell RCC. The genetic testing confirmed that the patient had VHL disease with de novo somatic mutation. Based on our case report, we systematically reviewed the characteristics of collision tumor composed of hemangioblastoma and metastatic RCC in VHL patients. The special growth site of our case is the first report of this kind of collision tumor, and can also help enrich our understanding of VHL disease and collision tumor.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease

Luo,

Sun,

2023

Case Rep Oncol

View full text Add to dashboard Cite

show abstract

“Intrasellar tumor-to-tumor metastasis: A single center experience with a systematic review”

Mansur,

Alsavaf,

Pasquini

et al. 2024

Pituitary

View full text Add to dashboard Cite

Purpose This study investigates the rare occurrence of tumor-to-tumor metastasis in Pituitary Neuroendocrine Tumors (PitNETs), also known as pituitary adenomas, aiming to enhance understanding of its diagnostic and therapeutic challenges. We report two cases from our institution of tumor-to-tumor metastasis involving PitNETs, followed by a systematic literature review. Methods We conducted a comprehensive literature review using PubMed and Google Scholar databases. This review provides insights into patient demographics, clinical presentations, primary tumor origin, management approaches and outcomes. Results We identified 38 documented cases of tumor-to-tumor metastasis involving the pituitary gland in the literature. This revealed a diverse range of primary tumor origins, with lung, breast, and renal carcinomas being the most prevalent. Clinical presentations varied, with visual disturbances emerging as the most frequently reported symptom. Surgical interventions predominantly resulted in subtotal resection. Kaplan–Meier survival analysis demonstrated that endoscopic endonasal approaches (EEA) are associated with longer median survival times compared to other surgical methods. Conclusion Tumor-to-tumor metastasis to PitNETs must be considered in differential diagnoses of sellar masses. Prompt and accurate diagnosis, coupled with a multidisciplinary treatment strategy, is essential. Our study contributes to the scarce literature on such metastases, providing a foundation for further understanding of this complex pathological entity.

show abstract

Collision of Two Tumors: A Case Report of a Lung Adenocarcinoma With Metastasis to a Pituitary Adenoma

Cited by 2 publications

References 12 publications

Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease

Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease

“Intrasellar tumor-to-tumor metastasis: A single center experience with a systematic review”

Contact Info

Product

Resources

About