Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis in the colon: a case report and literature review

Abstract

This report presents a case of collision tumors of low-grade B-cell lymphoma and adenocarcinoma in the sigmoid colon of an 81-year-old man. All surgically resected regional mesenteric lymph nodes were found to be occupied by low-grade B-cell lymphoma, and one lymph node showed the presence of adenocarcinoma. Low-grade B-cell lymphoma was also observed in the resected spleen. Moreover, concurrent tuberculosis infection in the resected colon was proven by the presence of positive results obtained with polymerase chain reaction analysis of the mycobacterial DNA. Systemic chemotherapy was administered for advanced colon cancer with lung metastasis, and anti-tuberculosis treatment was also prescribed. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectal region is rare. Furthermore, collisions of these different entities are also extremely unusual. The accurate clinical determination of the dominant tumor and a timely follow-up are required for the proper treatment of these cases.

Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: A case report and review of literature

“…The most common lymphoma found was diffuse large B-cell lymphoma. Of note, most cases initially presented with signs and symptoms suggestive of gastrointestinal disease and were subsequently found to have lymphoma, except for those described by Chang et al [18] and Lin et al [21]. In our case, the patient was found to have low grade adenocarcinoma in the descending colon and tubulovillous adenoma in the cecum both colliding with EBV-driven, lambda-restricted large B-cell lymphoma.…”

“…To our knowledge, there are fifteen cases of this type of collision to date, including this report (Table 1) [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. There is a male and elderly predominance at an average age The majority of collisions arise in the cecum or rectum, with eight arising from the right colon, one from the transverse colon, and six from the left colon.…”

Collision Tumors of the Gastrointestinal Tract: A Systematic Review of the Literature

“…Ten cases reported on lymph node infiltration, with intestinal adenocarcinoma being the leading histological element. One case presented a colliding pattern of infiltration from adenocarcinoma and B-cell lymphoma (20). All fourteen cases were surgically treated, seven of them (50%) received adjuvant therapy and no patient received neoadjuvant therapy.…”

A Case of Collision Tumor of MALT Lymphoma and Poorly Differentiated Adenocarcinoma Diagnosed Incidentally After Appendectomy for a Clinical Presentation of Acute Appendicitis.

“…Collision tumors of lymphoma and colorectal adenocarcinoma are rare entities and just a few studies exist [1][2][3][4][5][6][7][8] in the literature. In the case of mucosa-associated lymphoid tissue (MALT) lymphoma which is now known as marginal zone lymphoma MALT type, the gastrointestinal tract is the most frequently involved extranodal site with the stomach being the most common location [7].…”

“…Primary lymphoma of the colon is rare, comprising only 0.2% to 1.2% of all colonic malignancies [9], and colonic lymphomas represent 5.6% to 20% of all gastrointestinal lymphomas [10]. Furthermore, lymphoma synchronously accompanied by adenocarcinoma of the colon is extremely rare [6].…”