Collision tumor of the thyroid gland: Follicular carcinoma and papillary microcarcinoma

Abstract

Collision tumor represents the proximal coexistence of two histologically distinct tumors. The combination of two different types of tumors in a single thyroid gland is extremely unusual. We reported a case of follicular carcinoma and papillary microcarcinoma occur independently as a primary tumor separated by a normal tissue in a 59-yearold Saudi female, presented at the clinic with goiter for two months duration without symptoms of thyroid hormonal disorders. This case is one of few cases to be reported as a combined follicular thyroid carcinoma and papillary thyroid carcinoma in English literature.

A patient with a rare co‐occurrence of papillary and follicular thyroid carcinomas

“…The most reported TCT is PTC and MTC as highlighted in a recent case series by Ryan et al 2 . Though the co‐occurrence of PTC and other carcinomas in the thyroid have been reported, 19 the co‐existence of PTC and FTC are extremely rare, with only 20 cases reported in the English literature 3–18 . Among the cases of co‐existent PTC and FTC, the median age is 56 years old (range: 12–79 years old), with a female preponderance (66%) as per our review of current published English literature.…”

“…The most reported TCT is PTC and MTC as highlighted in a recent case series by Ryan et al 2 Though the co-occurrence of PTC and other carcinomas in the thyroid have been reported, 19 the coexistence of PTC and FTC are extremely rare, with only 20 cases reported in the English literature. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Among the cases of co-existent PTC and FTC, the median age is 56 years old (range: 12-79 years old), with a female preponderance (66%) as per our review of current published English literature. Additionally, lymph node metastasis was reported in four patients, 5,6,13,15 and distant metastasis to the rib/femur/shoulder bone, and adrenal gland have also been reported in four patients.…”

“…Ultrasonography of the thyroid using the TI‐RADs grading scale is both sensitive and specific to further guide the investigation of asymptomatic thyroid nodules 20 . TI‐RADs risk stratifies patients using a standardized scoring 1–5 system determined from five categories of ultrasound findings (composition, echogenicity, shape, margin, and echogenic foci). Higher cumulative scores indicate a greater likelihood of malignancy 21 .…”

“…Current literature reports that most thyroid collision tumors (TCT) are due to the co‐occurrence of papillary (PTC) and medullary thyroid carcinomas (MTC) 2 . However, there are only 20 cases to date that describe the concurrent presentation of both PTC and follicular thyroid carcinoma (FTC) 3–18 …”

“…2 However, there are only 20 cases to date that describe the concurrent presentation of both PTC and follicular thyroid carcinoma (FTC). [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]…”