Colloid Carcinoma of the Breast

Silverberg, Steven G.; Saul, Chitale Kay; Arun, Rajendran; Levitt, Seymour H.

doi:10.1093/ajcp/55.3.355

Cited by 92 publications

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“…[1][2][3][4][5]7 The diagnostic features of MC by breast FNA are well established in the literature. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Mucinous carcinoma often shows grossly visible jellylike mucin when obtained by FNA, which correlates to the abundant mucin in the background of the smears.…”

Section: Discussionmentioning

confidence: 99%

“…2011;135:1533-1538; doi: 10.5858/arpa.2010-0652-CP) P ure mucinous (colloid) carcinomas (MCs) represent about 1% to 6% of breast cancers. [1][2][3][4][5] These tumors are considered ''special-type'' carcinomas owing to their distinctive morphology and behavioral characteristics. Although the cytologic features of mucinous carcinoma of the breast in fine-needle aspiration (FNA) specimens are characteristic, the correlation of these features with the ability of cytologists to definitively identify this tumor has not been well studied.…”

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confidence: 99%

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Performance Characteristics of Mucinous (Colloid) Carcinoma of the Breast in Fine-Needle Aspirates: Observations From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology

Laucirica¹,

Bentz²,

Khalbuss³

et al. 2011

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Mucinous breast carcinoma has characteristic cytologic features, but few studies exist that analyze the reproducibility of this diagnosis. Objective.—To analyze participants' diagnosis of mucinous carcinoma in breast fine-needle aspiration (FNA) slides distributed in an educational interlaboratory peer comparison program. Design.—Participant responses for FNA slides with a reference diagnosis of mucinous carcinoma, distributed between 2001–2008 in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology, were evaluated for concordance with the general category and reference diagnosis of mucinous carcinoma. Results.—Of 8061 responses, 6353 (78.8%) were categorized as malignant; 775 (9.6%) as suspicious; and 933 (11.6%) as negative. The most frequent incorrect responses for the benign category included fibroadenoma (51.7%), nonspecified benign lesion (12%), fibrocystic changes (7.8%), and fat necrosis/granulomatosis/foreign body reaction (6.9%). Conventional Papanicolaou-stained preparations were reviewed for 58.7% (4732) of responses; of these, 39.4% (3177) were from modified Giemsa–stained smears and 1.9% (152) from ThinPrep slides. Papanicolaou-stained conventional smears had the lowest concordance (86.5%) when compared to modified Giemsa–stained smears (91.2%) and ThinPrep challenges (92.1%) (P < .001). Participants specifically diagnosed mucinous carcinoma 37.3% of the time, and modified Giemsa–stained challenges performed best (43.1%, P < .001). There was no significant difference between cytotechnologists' and pathologists' responses (87.9% versus 88.2%; P = .69). Conclusions.—Mucinous carcinoma in FNA was not accurately identified in a glass slide interlaboratory comparison program. We observed better performance with modified Giemsa–stained and ThinPrep slides than with Papanicolaou-stained preparations. The most common response for the benign category of mucinous carcinoma was fibroadenoma. Increased awareness of the cytologic features of mucinous carcinoma may improve accuracy in breast FNA.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Performance Characteristics of Mucinous (Colloid) Carcinoma of the Breast in Fine-Needle Aspirates: Observations From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology

Laucirica¹,

Bentz²,

Khalbuss³

et al. 2011

Archives of Pathology &Amp; Laboratory Medicine

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“…This entity has been well defined in the breast, colon, rectum, and pancreas 1, 2, 3. However, the clinicopathological characteristics of mucinous cholangiocarcinoma have not been elucidated owing to the rarity of this tumor.…”

Section: Introductionmentioning

confidence: 99%

Mucinous cholangiocarcinoma: Clinicopathological features of the rarest type of cholangiocarcinoma

Sumiyoshi¹,

Shima²,

Okabayashi³

et al. 2017

Annals of Gastroent Surgery

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Mucinous cholangiocarcinoma is extremely rare and its clinicopathological features remain unclear. The present study aimed to analyze published data on mucinous cholangiocarcinoma. Medical databases were searched from 1980 to 2016, and clinicopathological data for 16 mucinous cholangiocarcinoma patients were obtained. Characteristic imaging findings, including hypovascular tumor with peripheral enhancement on computed tomography and angiography, extremely high intensity on T2‐weighted magnetic resonance images, intratumoral calcification and luminal communication between the tumor and bile duct on cholangiography, were noted. Mucinous cholangiocarcinoma was correctly diagnosed in one patient only, with some patients diagnosed as low‐malignant biliary cystic tumors preoperatively. Five cases were followed up after the first medical examination, and three of these were initially diagnosed as biliary cystadenoma or intraductal papillary neoplasm of the bile duct. All five tumors showed marked enlargement within 4 months of follow up. Macroscopically, the resected tumors were non‐cystic/solid in seven cases, and cystic in seven. Tumor diameter ranged from 5 cm to 22 cm, and mucoid cut surface, lobulation, lack of capsule and papillary growth were observed. Microscopically, co‐existing intraductal papillary neoplasm of the bile duct was noted in three of five patients with available data. Nine of 10 cases in whom the pathological stage was reported had advanced disease with lymph node and/or distant metastasis, and 5‐year survival was achieved in one microinvasive case only. Overall 1‐ and 3‐year survival rates were 60.1% and 40.1%, respectively. The possibility of mucinous cholangiocarcinoma should be considered when biliary cystic tumors are detected on imaging modalities, despite the rarity of this tumor.

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“…Müsinöz meme kanseri tüm meme kanserlerinin %1-6'sı kadardır ve infiltratif duktal karsinomlara göre daha iyi bir prognoza sahiptir (1 Pür müsinöz meme karsinomu genellikle ileri yaşlarda görülmekle beraber, çok nadir olarak da 35 yaş altı hastalarda da rapor edilmiştir (2,4,5). En sık görülen şikayet memede tek taraflı ele gelen kitledir (4,5).…”

Section: Tartışma Ve Sonuçlarunclassified

“…En sık görülen şikayet memede tek taraflı ele gelen kitledir (4,5). Sonografik olarak hipoekoik, düzensiz veya mikrolobüle desen şeklin-de görülür (6)(7)(8).…”

Section: Tartışma Ve Sonuçlarunclassified

Pure and Mixed Mucinous Carcinoma of the Breast

Gündeş¹,

Aksoy²,

Vatansev³

et al. 2013

J Breasth Health

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Objective: Mucinous carcinoma of the breast is relatively rare and the prevalence of its pure form among all carcinomas of the breast is 2%. Its pure and mixed types have been defined. This study aims at evaluating therapeutic approaches to and prognostic features of mucinous carcinoma of the breast. Materials and Methods:The 24 patients, who had undergone surgery because of mucinous breast cancer at our clinic between 2004 and 2011, were categorized into two groups as pure and mixed according to their pathological diagnoses within the scope of the study.Results: All the cases were female and the median age was 54 years (37-84). While the number of patients with mixed mucinous carcinoma of the breast was 15, the number of patients with pure mucinous carcinoma of the breast was nine (37.5%). The median follow-up period of the patients was 40 (12-84) months. Axillary lymph node metastasis was seen only in one patient within the pure group (11%) while it was seen in nine cases in the mixed group. Thus, there was a statistically significant difference between the groups (p=0.001). Local recurrence was seen only in one patient in the mixed group. While there were six patients with distant metastases in the mixed group, there was no distant metastasis in the pure group (p=0.028). Conclusion:Pure mucinous breast cancers have better prognoses than other invasive breast cancers. Pure mucinous carcinoma of the breast is a type of cancer with which physicians may achieve gratifying results through treatment carried out in line with oncological principles.Key words: Breast cancer, mucinous carcinoma, mastectomy ÖZET Amaç: Müsinöz meme kanserleri nispeten nadirdir ve pür halinin tüm meme karsinomları içerisinde görülme sıklığı %2'dir. Pür ve mikst tipleri tarif edilmiştir. Bu çalışmada müsinöz meme kanserindeki tedavi yaklaşım-ları ve prognostik özelliklerin değerlendirilmesi amaçlanmıştır. Yöntem ve Gereçler:Bu çalışmada kliniğimizde 2004-2011 yılları arasında müsinöz meme kanseri nedeniyle ameliyat edilen 24 olgu patolojik tanılarına göre pür ve miks olarak iki gruba ayrıldı. Bulgular:Olguların tamamı bayan ve ortanca yaşı 54(37-84) idi. Miks müsinöz meme karsinomlu hasta sayısı 15 (%62.5), pür müsinöz meme karsinomlu hasta sayısı ise dokuz (%37,5) idi. Hastaların ortanca izlem süresi 40 (12-84) aydı. Pür grupta aksiller lenf nodu metastazı sadece bir (%11) olguda mevcut olup miks grupta ise dokuz olguda saptanmış olup istatistiksel olarak anlamlı fark vardı (p=0,001). Sadece miks grupta bir hastada lokal nüks görüldü. Miks grupta uzak metastazı olan hasta sayısı altı iken, pür grupta uzak metastaz saptanmadı. İki grup arasında uzak metastaz gelişimi açısından anlamlı fark vardı (p=0,028). Sonuç:Pür müsinöz meme kanserlerinin diğer invaziv meme kanserlerine göre prognozu oldukça iyidir. Pür müsinöz meme karsinomları onkolojik prensiplere uyularak yapılan tedaviyle yüz güldürücü neticeler alınabilen bir kanser türüdür. Anahtar sözcükler: Meme kanseri, müsinöz karsinom, mastektomi GirişMüsinöz meme karsinomu nadir gö...

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Colloid Carcinoma of the Breast

Cited by 92 publications

References 0 publications

Performance Characteristics of Mucinous (Colloid) Carcinoma of the Breast in Fine-Needle Aspirates: Observations From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology

Performance Characteristics of Mucinous (Colloid) Carcinoma of the Breast in Fine-Needle Aspirates: Observations From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology

Mucinous cholangiocarcinoma: Clinicopathological features of the rarest type of cholangiocarcinoma

Pure and Mixed Mucinous Carcinoma of the Breast

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