Colloidal carriers for extended absorption window of furosemide

Abstract

The recorded results highlighted the potential for SMEDDS and niosomes for widening the absorption window of acidic drugs after oral administration.

Intestinal Absorption of Eprosartan Mesylate From Self Emulsifying System and Cyclodextrin Complex

“…The same trend was shown after perfusion of the drug in the form of an inclusion complex with HPβCD. The use of nanoemulsion was able to extend the absorption window of furosemide which is known to be mainly ionised in the intestinal pH [15]. This agrees with the current finding which showed good potential for enhancing the intestinal absorption of eprosartan mesylate which is known to be mainly ionised at intestinal pH.…”

“…This can be attributed to its existence in an ionised form in the pH of the tested intestinal segments. Dependence of drug absorption on the degree of ionisation was noticed by the same technique [15]. Comparing the intestinal membrane transport parameters recorded after perfusion through the jejunoileum with those recorded in case of the colon, the absorption pattern can be considered site dependent with the colon being superior per unit length.…”

“…The study protocol was approved by the ethical committee of the college of pharmacy, university of Tanta (approval number, 206014). The procedures for the preparation of isolated intestinal segments are well documented in literature with the detailed presentation being reported recently [15,16]. The study employed 9 male albino rabbits with an average weight of 2-2.25 kg obtained from Tanta animal house.…”

“…This technique is being in use for a long period of time with many articles being published recently utilising the same method due to its advantages. The rabbit was selected as the test animal due to its intestinal physiology which simulates the human system [15]. Perfusion of an aqueous solution of eprosartan mesylate (control) through the selected intestinal segments produced membrane transport parameters highlighting the incomplete absorption of the drug from the tested intestinal segments (table 3).…”

“…Systems having an absorbance value below 0.1 were considered nanoemulsions with their undiluted system being classified as a self-nano emulsifying system. Those producing absorbance values above 0.1 were considered as a coarse emulsion with the undiluted systems being classified as self-emulsifying drug delivery systems [15].…”