Colloidal properties and in vitro evaluation of Hydroxy ethyl cellulose coated iron oxide particles for targeted drug delivery

Bekaroğlu, Maide Gökçe; İşçi, Yavuz; İşçi, Sevim

doi:10.1016/j.msec.2017.04.030

Cited by 36 publications

(18 citation statements)

References 15 publications

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“…Nanoparticle surface coating and functionalization are major components of nanoparticles which allow them to be used for specific applications. The surface coating can be altered to increase biocompatibility [ 79 ], to enhance paramagnetic or superparamagnetic properties for clinical and therapeutic applications [ 80 , 81 ], or to enhance catalytic properties [ 82 , 83 ]. An increase in coating thickness (and subsequent overall nanoparticle size) will increase relaxation times, allowing for better imaging results [ 84 ].…”

Section: “Safe By Design” Ionps Hazard Reduction Strategiesmentioning

confidence: 99%

Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk

et al. 2017

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Fine/micron-sized iron oxide particulates are incidentally released from a number of industrial processes, including iron ore mining, steel processing, welding, and pyrite production. Some research suggests that occupational exposure to these particulates is linked to an increased risk of adverse respiratory outcomes, whereas other studies suggest that iron oxide is biologically benign. Iron oxide nanoparticles (IONPs), which are less than 100 nm in diameter, have recently surged in use as components of novel drug delivery systems, unique imaging protocols, as environmental catalysts, and for incorporation into thermoplastics. However, the adverse outcomes associated with occupational exposure to IONPs remain relatively unknown. Relevant in vivo studies suggest that pulmonary exposure to IONPs may induce inflammation, pulmonary fibrosis, genotoxicity, and extra-pulmonary effects. This correlates well with in vitro studies that utilize relevant dose, cell type(s), and meaningful end points. A majority of these adverse outcomes are attributed to increased oxidative stress, most likely caused by particle internalization, dissolution, release of free iron ions, and disruption of iron homeostasis. However, because the overall toxicity profile of IONPs is not well understood, it is difficult to set safe exposure limit recommendations that would be adequate for the protection of at-risk workers. This review article will focus on known risks following IONPs exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.

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Section: “Safe By Design” Ionps Hazard Reduction Strategiesmentioning

confidence: 99%

Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk

et al. 2017

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“…NCC exhibits remarkable properties, such as high surface area, thermally stable, renewable, biodegradable, non-toxic [6][7][8] and accessible industrially in large scale. 9 NCC has been extensively researched as key components in the design of super capacitors, [10][11][12] aerogels, 13 sensors, 14 pharmaceuticals, 15 chiral materials 16 and catalysts. 17 They are generated by the removal of amorphous regions of different sources of cellulose using acid hydrolysis, enzymatic or mechanical treatments.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Nitrite in Food Based on Poly (3,4-ethylenedioxythiophene) Doped with Fe3O4 Nanoparticles Loaded Carboxylated Nanocrystalline Cellulose

Zhang²,

Yu³

2018

ACSi

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Carboxylated nanocrystalline cellulose (CNCC) was prepared by oxidation degradation of microcrystalline cellulose (MCC) using ammonium peroxydisulfate and modified with Fe 3 O 4 nanoparticles to form Fe 3 O 4-CNCC nanocomposite via simple refluxing process. The Fe 3 O 4-CNCC nanocomposite doped poly(3,4-ethylenedioxythiophene) (PEDOT) was successfully decorated on the glassy carbon electrode (GCE) by electrochemical deposition. The PEDOT/Fe 3 O 4-CNCC modified GCE with enlarged real electrochemical surface area was used to determine nitrite with high selectivity, sensitivity and outstanding reproducibility. Using amperometric current-time (i-t) curve, the proposed sensor provided a wider linear range (0.5-2500 μM) and a lower detection limit (0.1 μM) towards nitrite compared with the method of differential pulse voltammetry (DPV). This analytical method gave good selectivity in the practical measurement of nitrite in pickles.

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“…Starch, ethyl cellulose, chitosan, and gelatin polysaccharides are also used by several researchers to coat iron oxide nanoparticles for MRI, drug delivery, and different biomedical applications. [28][29][30][31][32][33][34][35] Saboktakin et al used iron oxide nanoparticles of 10 nm diameter coated with starch for MRI. 28 Saikia et al studied the pH-sensitive drug delivery potentiality of starch-coated iron oxide nanoparticles (8-20 nm), 29 whereas Ma et al and Bekaroğlu et al reported the successful application of hydroxyethyl cellulose-coated iron oxide nanoparticles in targeted drug delivery.…”

mentioning

confidence: 99%

“…28 Saikia et al studied the pH-sensitive drug delivery potentiality of starch-coated iron oxide nanoparticles (8-20 nm), 29 whereas Ma et al and Bekaroğlu et al reported the successful application of hydroxyethyl cellulose-coated iron oxide nanoparticles in targeted drug delivery. 30,31 Gaihre et al reported gelatincoated doxorubicin-loaded iron oxide nanoparticles and their drug-loading and drug-releasing kinetics with variable pH. 32,33 In food industry, fatty acid-coated iron oxide nanoparticles are widely used as biocatalyst because of their excellent catalytic activity and easy separation of the catalyst post-reaction by applying an external magnetic field.…”

mentioning

confidence: 99%

Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

Mondal¹,

Manivasagan²,

Bharathiraja³

et al. 2017

IJN

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In this review, specific attention is paid to the development of nanostructured magnetic hydroxyapatite (MHAp) and its potential application in controlled drug/gene delivery, tissue engineering, magnetic hyperthermia treatment, and the development of contrast agents for magnetic resonance imaging. Both magnetite and hydroxyapatite materials have excellent prospects in nanomedicine with multifunctional therapeutic approaches. To date, many research articles have focused on biomedical applications of nanomaterials because of which it is very difficult to focus on any particular type of nanomaterial. This study is possibly the first effort to emphasize on the comprehensive assessment of MHAp nanostructures for biomedical applications supported with very recent experimental studies. From basic concepts to the real-life applications, the relevant characteristics of magnetic biomaterials are patented which are briefly discussed. The potential therapeutic and diagnostic ability of MHAp-nanostructured materials make them an ideal platform for future nanomedicine. We hope that this advanced review will provide a better understanding of MHAp and its important features to utilize it as a promising material for multifunctional biomedical applications.

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Colloidal properties and in vitro evaluation of Hydroxy ethyl cellulose coated iron oxide particles for targeted drug delivery

Cited by 36 publications

References 15 publications

Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk

Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk

Electrochemical Detection of Nitrite in Food Based on Poly (3,4-ethylenedioxythiophene) Doped with Fe3O4 Nanoparticles Loaded Carboxylated Nanocrystalline Cellulose

Magnetic hydroxyapatite: a promising multifunctional platform for nanomedicine application

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