Colloidal stability and drug incorporation aspects of micellar-like PLA–PEG nanoparticles

Riley, Trevor; Govender, Thirumala; Stolnik, Snow; Xiong, Chenyan; Garnett, Martin C.; Illum, Lisbeth; Davis, S.S.

doi:10.1016/s0927-7765(99)00066-1

Cited by 200 publications

(144 citation statements)

References 25 publications

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“…An increase in FALT with increase in PEG molecular weight led to enhancement in escape from reticuloendothelial system and augmentation in tumor uptake of liposomes (Sadzuka et al, 2002(Sadzuka et al, , 2006. Similar kind of results were observed, and the copolymer with PEG of molecular weight 5000 g showed higher FALT compared to micelles prepared with PEG of molecular weight 2000 g. A reduction in FALT was also seen with increase in the molecular weight of PCL block; these may be attributed due to decrease in PEG surface coverage (Riley et al, 1999). Interactions of nanocarrier with serum proteins present in blood after intravenous administration decide the in vivo fate of nanocarrier by two possible mechanisms (Liu et al, 2005).…”

Section: Discussionsupporting

confidence: 72%

Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles

et al. 2012

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Section: Discussionsupporting

confidence: 72%

Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles

et al. 2012

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“…At nanoparticle surface, the area available per PEG chain at the outer boundary of the shell is dependent on PEG to PLA molecular weight ratio that governs the PLA packing density and the surface curvature (linked to the nanoparticle size) of the assembly. 57,58,71 As an example, an increase in the diameter of nanoparticles made of mPEG 5000 -PLA 45000 results in a lower surface curvature, thus in an apparent increase in PEG surface coverage 59 and in an improved colloidal stability. 58 …”

Section: Nanoparticle Preparationmentioning

confidence: 99%

“…57,58,71 As an example, an increase in the diameter of nanoparticles made of mPEG 5000 -PLA 45000 results in a lower surface curvature, thus in an apparent increase in PEG surface coverage 59 and in an improved colloidal stability. 58 …”

Section: Nanoparticle Preparationmentioning

confidence: 99%

“…65 PEG conformation at the PLA-PEG nanoparticle surface is of utmost importance for the opsoninrepelling function of the PEG layer and has been extensively studied. [57][58][59]66,68 The PEG layer thickness depends on the PEG molecular weight and surface density. 57 Depending on their surface density, PEG blocks have brush-like (elongated coil, high density) or mushroom-like (random coil, low density) conformations.…”

Section: Nanoparticle Preparationmentioning

confidence: 99%

“…It is generally admitted that hydrophobic surfaces promote protein adsorption and that negative surfaces are activators of the complement system. 76 Following the rule hydrophobic and negative PLA or PLGA nanoparticle surfaces 57,58 activate the complement system 32 and coagulation factors 77 in vitro. In contrast, hydrophilic coating with PEG sterically stabilizes PLA or PLGA nanoparticles and reduces opsonization and phagocytosis in vitro 32 or ex vivo, 78 and uptake by neutrophilic granulocytes in vivo.…”

Section: Pharmacokineticsmentioning

confidence: 99%

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Summary: Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50 -300 nm generally). They cannot freely diffuse through the bloodbrain barrier (BBB) and require receptor-mediated transport through brain capillary endothelium to deliver their content into the brain parenchyma. Polysorbate 80-coated polybutylcyanoacrylate nanoparticles can deliver drugs to the brain by a still debated mechanism. Despite interesting results these nanoparticles have limitations, discussed in this review, that may preclude, or at least limit, their potential clinical applications. Long-circulating nanoparticles made of methoxypoly(ethylene glycol)-polylactide or poly(lactide-co-glycolide) (mPEG-PLA/ PLGA) have a good safety profiles and provide drug-sustained release. The availability of functionalized PEG-PLA permits to prepare target-specific nanoparticles by conjugation of cell surface ligand. Using peptidomimetic antibodies to BBB transcytosis receptor, brain-targeted pegylated immunonanoparticles can now be synthesized that should make possible the delivery of entrapped actives into the brain parenchyma without inducing BBB permeability alteration. This review presents their general properties (structure, loading capacity, pharmacokinetics) and currently available methods for immunonanoparticle preparation.

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Modulation of Intracellular Oxygen Pressure by Dual‐Drug Nanoparticles to Enhance Photodynamic Therapy

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et al. 2019

Adv Funct Materials

114

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Oxygen plays an essential role in the photodynamic therapy (PDT) of cancer. However, hypoxia inside tumors severely attenuates the therapeutic effect of PDT. To address this issue, a novel strategy is reported for cutting off the oxygen consumption pathway by using sub‐50 nm dual‐drug nanoparticles (NPs) to attenuate the hypoxia‐induced resistance to PDT and to enhance PDT efficiency. Specifically, dual‐drug NPs that encapsulate photosensitizer (PS) verteporfin (VER) and oxygen‐regulator atovaquone (ATO) with sub‐50 nm diameters can penetrate deep into the interior regions of tumors and effectively deliver dual‐drug into tumor tissues. Then, ATO released from NPs efficiently reduce in advance cellular oxygen consumption by inhibition of mitochondria respiratory chain and further heighten VER to generate greater amounts of 1O2 in hypoxic tumor. As a result, accompanied with the upregulated oxygen content in tumor cells and laser irradiation, the dual‐drug NPs exhibit powerful and overall antitumor PDT effects both in vitro and in vivo, and even tumor elimination. This study presents a potential appealing clinical strategy in photodynamic eradication of tumors.

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Colloidal stability and drug incorporation aspects of micellar-like PLA–PEG nanoparticles

Cited by 200 publications

References 25 publications

Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles

Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles

Drug transport to brain with targeted nanoparticles

Modulation of Intracellular Oxygen Pressure by Dual‐Drug Nanoparticles to Enhance Photodynamic Therapy

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