Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms

Santander-Ortega, Manuel J.; Jódar-Reyes, Ana Belén; Csaba, Nœmi; Bastos‐González, Delfi; Ortega-Vinuesa, J.L.

doi:10.1016/j.jcis.2006.07.031

Cited by 187 publications

(143 citation statements)

References 31 publications

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“…Ortega et al [26] found a sharp increase in the adsorption isotherm of PF68 coated PLGA particles for low PF68 concentration (up to 100 mg/L), whilst above that value, the increase was quite steady, and reached a plateau, which supports our findings .…”

Section: Discussionsupporting

confidence: 92%

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Shubhra

Tóth

Gyenis

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Lifetime prolongation for hydrophobic drug carriers has been the focus of interest for many years. Poloxamer (Pluronic F68, PF68) has been employed in this study for modifying the surface of magnetic poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with human serum albumin (HSA) model drug. Surface characteristics of untreated and PF68 treated NPs were analyzed by size, zeta potential and electrophoretic mobility studies. UV/VIS spectroscopic analysis, isothermal titration calorimetry (ITC) and dynamic light scattering methods were used to investigate serum protein (bovine serum albumin, BSA) adsorption. Results showed the successful surface attachment of PF68. Among different concentrations (0.1 to 1% wt/vol) of PF68 studied, 0.5% was found to be the most useful, since a higher concentration can issue in micelle formation. 50% less BSA tended to be adsorbed on the treated NPs in comparison to the untreated ones.

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Section: Discussionsupporting

confidence: 92%

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Shubhra

Tóth

Gyenis

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…That decrease in zeta potential is clearly due to the presence of protonated amine groups of Pluronic-amine. Bare PLGA particles are stabilized in aqueous solution by electrostatic interactions due to their negative surface charge [44]. The stability of such systems vanishes above a certain electrolyte concentration due to the screening effect of ionic strength.…”

Section: Preparation and Characterizationmentioning

confidence: 99%

Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles

Gyulai

Magyar²,

Rohonczy

et al. 2016

Express Polym. Lett.

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“…Surface charge is the parameter that affects body distribution and interaction with the biological environment. Zeta potential measurement involves consideration of the electric potential, i.e., diffusion coefficient and electrophoretic mobility (61). These values are transformed to zeta potential after calculating them from the Smoluchowski equation or Stokes equation.…”

Section: Characterization Of Nanospongesmentioning

confidence: 99%

Cyclodextrin based nanosponges for pharmaceutical use: A review

Tejashri¹,

Amrita²,

Darshana³

2013

Acta Pharmaceutica

197

100

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Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. Well--known examples of nanosponges are titanium-based nanosponges (1), silicon nano- Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. These nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release as well as improve a drug's bioavailability by modifying the pharmacokinetic parameters of actives. Development of nanosponges as drug delivery systems, with special reference to cyclodextrin based nanosponges, is presented in this article. In the current review, attempts have been made to illustrate the features of cyclodextrin based nanosponges and their applications in pharmaceutical formulations. Special emphasis has been placed on discussing the methods of preparation, characterization techniques and applications of these novel drug delivery carriers for therapeutic purposes. Nanosponges can be referred to as solid porous particles having a capacity to load drugs and other actives into their nanocavity; they can be formulated as oral, parenteral, topical or inhalation dosage forms. Nanosponges offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility and delayed release of actives. Controlled release of the loaded actives and solubility enhancement of poorly water-soluble drugs are major advantages of nanosponge drug delivery systems.

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Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms

Cited by 187 publications

References 31 publications

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Surface modification of HSA containing magnetic PLGA nanoparticles by poloxamer to decrease plasma protein adsorption

Preparation and characterization of cationic Pluronic for surface modification and functionalization of polymeric drug delivery nanoparticles

Cyclodextrin based nanosponges for pharmaceutical use: A review

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