2007
DOI: 10.1016/j.ijpharm.2006.11.002
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Colloidal stability of ultrasmall superparamagnetic iron oxide (USPIO) particles with different coatings

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Cited by 64 publications
(52 citation statements)
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“…[30][31][32] However, this nonspecific imaging of atherosclerotic plaque was obtained with dextran coated USPIO formulations, whereas our USPIO derivatives were efficiently rendered stealthy by the covalent conjugation of PEG. 33 The stealth behavior of USPIO-PEG is reflected by the kinetics of plaque enhancement in our MRI experiments, where this contrast agent was not retained 24 hours after administration; this result was confirmed by histology following Perl' s-DAB staining. The contrast generated by simple plaque perfusion is illustrated by USPIO-NSP, which only attained 30% of the specific plaque enhancement, as observed with USPIO-R832 and USPIO-R826.…”
Section: In Vivo Behavior Of Functionalized Uspio Derivatives and Persupporting
confidence: 62%
“…[30][31][32] However, this nonspecific imaging of atherosclerotic plaque was obtained with dextran coated USPIO formulations, whereas our USPIO derivatives were efficiently rendered stealthy by the covalent conjugation of PEG. 33 The stealth behavior of USPIO-PEG is reflected by the kinetics of plaque enhancement in our MRI experiments, where this contrast agent was not retained 24 hours after administration; this result was confirmed by histology following Perl' s-DAB staining. The contrast generated by simple plaque perfusion is illustrated by USPIO-NSP, which only attained 30% of the specific plaque enhancement, as observed with USPIO-R832 and USPIO-R826.…”
Section: In Vivo Behavior Of Functionalized Uspio Derivatives and Persupporting
confidence: 62%
“…The diffusion potential ψ d value is assumed very close to the value of the zeta potential (ζ ) and in this study ζ was used for Ψ d . Similar assumptions have been made by other researchers [3,18,23,24]. The Hamaker constant of boron nanoparticles, H BWB , is treated as a fitting parameter in Eq.…”
Section: The Dlvo Modelmentioning
confidence: 85%
“…According to the DLVO model the stability ratio is a function of the van der Waals attraction, V A , and the electrostatic double layer interaction, V E . The equation is written as [19,23]:…”
Section: The Dlvo Modelmentioning
confidence: 99%
“…Low shear was used to prevent formation of an emulsion. Hydrodynamic diameters were determined using dynamic light scattering (DLS) analysis performed on a custom-built apparatus using a scattering angle of 90° [30]. At least three measurements lasting 2 min each were conducted for every dispersion.…”
Section: Nanocluster Characterizationmentioning
confidence: 99%