In recent years, the importance of advanced manufacturing in the innovation and sustainability of nations and regions has been demonstrated. Several studies have highlighted the need to maintain and build an advanced manufacturing-enterprise-innovation ecosystem (AMEIE). Thus, in this paper, the symbiosis-evolution model of AMEIE is established according to ecological theory. On the basis of analyzing the evolution equilibrium and its stability conditions, different symbiosis-evolution scenarios were examined through a computer simulation. The results showed the following; (1) AMEIE is a complex system composed of advanced manufacturing enterprises, new-generation information-technology enterprises, and innovation-service organizations that create value cooperatively around resource acquisition and innovation interaction in a given symbiotic environment; (2) in this innovation ecosystem, symbiosis-evolution results depend on the symbiotic coefficient between the subjects; (3) the synergy of the subjects can be maximized in mutualism symbiosis evolution, while system members should strive to switch from parasitic symbiosis evolution or partial symbiosis evolution to mutualism symbiosis evolution. Therefore, countermeasures and suggestions are proposed, such as balancing the dynamics of population symbiosis evolution, optimizing the symbiotic environment, and formulating and improving efficient collaborative innovation mechanisms, which can provide theoretical support to the promotion of the evolution and development of AMEIE, along with mutualism symbiosis evolution.