“…Lichen planus (LP) has been previously associated with vitiligo [23,24,25,26,27,28,29,30,31]. Furthermore, some authorities consider FFA as a variant of LPP [19,20].…”
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia characterized by a progressive band-like recession of the frontotemporal hairline and frequent loss of the eyebrows. It predominantly affects postmenopausal women. Coexistence of FFA and vitiligo is rarely reported in the literature. We retrospectively studied 20 cases diagnosed with FFA in a 14-month period in our Department. Among them, there were 2 cases, a 72-year-old woman and a 48-year-old man, who developed FFA on preexisting vitiligo of the forehead. Anatomical colocalization of the two dermatoses supports the notion that a causal link may exist and their association may not be coincidental. We suggest that interrelated immunologic events and pathologic processes may underlie both these skin conditions.
“…Lichen planus (LP) has been previously associated with vitiligo [23,24,25,26,27,28,29,30,31]. Furthermore, some authorities consider FFA as a variant of LPP [19,20].…”
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia characterized by a progressive band-like recession of the frontotemporal hairline and frequent loss of the eyebrows. It predominantly affects postmenopausal women. Coexistence of FFA and vitiligo is rarely reported in the literature. We retrospectively studied 20 cases diagnosed with FFA in a 14-month period in our Department. Among them, there were 2 cases, a 72-year-old woman and a 48-year-old man, who developed FFA on preexisting vitiligo of the forehead. Anatomical colocalization of the two dermatoses supports the notion that a causal link may exist and their association may not be coincidental. We suggest that interrelated immunologic events and pathologic processes may underlie both these skin conditions.
“…Elevated levels of TNF-α and IL-6 have been found in vitiligo skin when compared to adjacent uninvolved skin [18,19,20,21]. Acute GVHD appeared to be induced by a synergistic interaction of IL-6, γ-interferon and TNF-α.…”
Aim: To investigate the prevalence and clinical characteristics of vitiligo after allogeneic hematopoietic cell transplantation (AHCT). Methods: The development of vitiligo was analyzed among 421 patients who underwent AHCT in Ibni Sina Hospital (University of Ankara) between 1988 and 2004. Results: Among 421 patients, we describe 6 with generalized vitiligo occurring after AHCT for chronic myelogenous leukemia. Five of them had severe chronic graft-versus-host disease (GVHD). Vitiligo was accompanied by alopecia areata and acquired ichthyosis in 2 patients with GVHD. Conclusion: Melanocyte destruction caused by the autoimmune reactions triggered by chronic GVHD as well as a genetic predisposition might have played a role in the development of vitiligo in our patients. These data support the hypothesis that vitiligo is an autoimmune entity.
“…[6] opisali współwystępowanie dermatoz u matki i cór-ki. Zaledwie jeden opis dotyczył okolic genitalnych (moszny) [7]. Hipotezy tłumaczące współistnienie bielactwa i liszaja płaskiego uwzględniają wspólne szlaki etiopatogenetyczne oraz koincydencję dermatoz.…”
Section: Listy Do Redakcjiunclassified
“…Potwierdza to występowa-nie wykwitów w przebiegu liszaja płaskiego w obrębie plam bielaczych na skórze eksponowanej na słońce oraz u pacjentów poddanych fototerapii [1,4]. Zjawisko to tłumaczy się zwiększonym pod wpły-wem promieniowania UV uwalnianiem czynników prozapalnych (TNF-α), indukujących naciek z efektorowych limfocytów T [7]. Wydaje się, że teoria ta jest spójna w odniesieniu do opisywanego przez nas chorego, który eksponował okolice genitalne na promieniowanie ultrafioletowe podczas fotochemoterapii.…”
Section: Listy Do Redakcjiunclassified
“…Doniesienie Göktay i wsp. [7] wydaje się jednak zaprzeczać tej hipotezie. Autorzy przedstawili przypadek mężczyzny, u którego liszaj płaski pojawił się w obrębie plam bielaczych nieeksponowanych na promieniowanie ultrafioletowe (moszna i pachwiny).…”
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