Colon adenocarcinoma metastatic to the larynx

Abstract

Secondary neoplasms of the larynx are rare and account for 0.09 to 0.4% of all laryngeal tumors. These tumors can occur by hematogenous or lymphogenous spread and may represent a diagnostic dilemma when the laryngeal localization is the only manifestation of disease. When multiple metastases are present, the appropriate treatment becomes even more controversial. To our knowledge only 148 cases of metastatic laryngeal neoplasms have been reported in the literature, with cutaneous melanomas and carcinomas from the kidney representing the most frequent primary sites of origin. Our research of the available literature has shown that only nine cases of metastases from colon adenocarcinomas have been described. In general, the overall prognosis of patients with a secondary laryngeal tumor is poor, since involvement of the larynx by a distant tumor commonly occurs in the terminal phase of the primary disease process. As such, the aim of treatment frequently is only to improve the quality of life of the patient. We report a case of colon adenocarcinoma metastatic to the larynx and discuss the problems related to its pathogenesis, diagnosis and treatment.

Laryngeal Involvement of Rhabdomyosarcoma in an Adult

“…Although it is difficult to make the distinction between metastatic or primary for sure, we supposed our case was a metastatic invasion rather than primary in an adult owing to previous diagnosis of rhabdomyosarcoma, similar histology and multiplicity of the tumor and rarity of primary involvement of larynx in adults [4]. …”

“…Primary involvement of the larynx by mesenchymal tumors has been reported as case reports [2,3]. Metastasis to the larynx from a neoplasia elsewhere is even rare, making 0.09 % to 0.4 % of total [4]. Until present, about 150 metastatic cancers of larynx of various histology have been reported.…”

Subglottic Metastasis of Adenoid Cystic Carcinoma from an Anterior Tangue Primary

“…lung to larynx). There is a suggestion that tumor cells implant onto the subglottic area from expectorated neoplastic cells when metastatic or primary lesions exist in the lungs, though insufficient evidence exists to support this [5].…”

Renal cell carcinoma metastasis to the vocal cord: A case report

“…[1] Metastasis to the larynx most often originates from melanomas (29%) or carcinomas derived from the kidney (25%), gastrointestinal tract (14%), lung (9%), breast (8%), and prostate (5%). Metastatic lesions to the larynx primarily affect the supraglottic region (35%-40%), followed by the subglottic region (10%-20%) and glottis (5%-10%).…”