Colon cancer in malrotated gut: A case report

Abstract

Malrotation of the gut is a rare congenital anomaly that mostly presents in the 1st month of life. Very rarely, it is found during adulthood either as an asymptomatic incidental finding or at autopsy. Presenting in adulthood with colon cancers is extremely rare. Here, we present the case of a middle-aged male patient with unexplained anemia which on investigation was found to have adenocarcinoma at the hepatic flexure of the colon. The staging computed tomography scan of the abdomen showed the growth at the hepatic flexure with malrotation of the gut. During the laparoscopic assessment, the cecum and ascending colon were found on the left side, and hence, a formal midline incision was made. Cecum was found on the left of the midline along with Ladd’s band. Extended right hemicolectomy was performed, dividing the Ladd’s band, taking care of the anomalous position of superior mesenteric vessels. The post-operative period was uneventful. Histopathological examination revealed this to be well-differentiated adenocarcinoma (pT3N1b). He thereafter received adjuvant chemotherapy and remains well after 5 years of follow-up. Presentation of malrotation of the gut in adulthood is seen in only 10–15% of cases as an incidental finding or at autopsy. Cancers in the colon in these patients are extremely rare. The treatment for colon cancer remains the same although one has to be careful about the vascular anomaly during the resection.

Skin as an interface: Understanding the synergy of dermatology, biomimetics and tribology

“…Notably, measurements involving steel spheres yielded the highest friction coefficients. Moreover, in various friction experiments, wherein alternative probes were employed alongside linear sliding movements [114,130,137,140], the estimated contact pressures were consistently maintained at relatively low levels.…”

“…A study conducted by Pailler-Mattei et al [139] illuminated how the skin surface lipid film influences skin adhesion properties through capillary phenomena. Likewise, Gupta et al [137] presented noteworthy findings, illustrating a moderate positive linear correlation between sebum levels and the forearm skin's friction when measured against steel.…”

“…Comprising a blend of water from sweat and sebum secreted by sebaceous glands, the hydrolipid film envelops the stratum corneum. In the domain of skin tribology, the role and significance of sebum lipids and their interactions with water have sparked debates and controversies [107,[136][137][138][139]. A study conducted by Pailler-Mattei et al [139] illuminated how the skin surface lipid film influences skin adhesion properties through capillary phenomena.…”