Colon Cancer in the Splenic Flexure

Nakashima, Masayuki; Akiyoshi, Takashi; Ueno, Masashi; Fukunaga, Yosuke; Nagayama, Satoshi; Fujimoto, Yoshiya; Konishi, Tsuyoshi; Noaki, Rota; Yamakawa, Keiko; Nagasue, Yasutomo; Kuroyanagi, Hiroya; Yamaguchi, Toshiharu

doi:10.1097/sle.0b013e31823aca96

Cited by 38 publications

(10 citation statements)

References 17 publications

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“…Other reports of laparoscopic resection of splenic flexure colon cancer reported a conversion rate of 0%–6.3% [131415]. One reason for conversion in our study was anastomosis site twisting.…”

Section: Discussionmentioning

confidence: 51%

“…Ideally, comparisons should be made between groups with similar basic characteristics, and this is an inherent limitation of the retrospective design and small population of this study. The appropriate resection range for splenic flexure colon cancer has not yet been established [13], and the length of the resection margin in previous studies was about 6–10 cm [1315]. With median proximal and distal resection margins of 8.9 and 8.6 cm, respectively, in the OC group, the OC in this study seems acceptable as a conventional open surgery for splenic flexure colon cancer.…”

Section: Discussionmentioning

confidence: 71%

“…The only known reports on this condition pertain to the short-term safety of laparoscopic surgery [1314] and the comparison of short-term outcomes of laparoscopic splenic flexure colon cancer surgery to that of open surgery [15]. In particular, there are no known reports comparing long-term survival outcomes of laparoscopic surgery to open surgery for this lesion.…”

Section: Discussionmentioning

confidence: 99%

“…Although average operative time increased by over an hour due to the technical difficulty of laparoscopic surgery, there were no differences in perioperative complications and patient recovery was faster, as shown by sooner resumption of bowel movement and shorter length of postoperative hospital stay. Nakashima et al [15] compared short-term outcomes of laparoscopic and open surgery for splenic flexure colon cancer. They also reported longer operative times in the LAC group and better outcomes for flatulence, diet resumption, and postoperative hospital stay.…”

Section: Discussionmentioning

confidence: 99%

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Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery

et al. 2017

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PurposeFew studies about laparoscopic surgery for splenic flexure colon cancer have been published. This study aims to compare the short- and long-term outcomes of laparoscopic surgery for splenic flexure colon cancer with those of conventional open surgery.MethodsFrom January 2004 to December 2010, 51 consecutive patients who underwent curative resection for stages I–III splenic flexure colon cancer were enrolled. Thirty-three patients underwent laparoscopy-assisted colectomy, while 18 patients underwent conventional open colectomy. Short- and long-term outcomes of the 2 groups were compared.ResultsThere were no differences in baseline characteristics, intra- and postoperative complications. The laparoscopy group showed longer operation time (median [interquartile range, IQR]: 295.0 [255.0–362.5] minutes vs. 180.0 [168.8–206.3] minutes, P < 0.001). In the laparoscopy group, return of bowel function was faster (median [IQR]: 3 [2–4] vs. 4 [3–5], P = 0.007) and postoperative hospital stay was shorter (median [IQR]: 9 [8–11] vs. 10.5 [9–19], P = 0.026). There were no statistically significant differences in overall survival rate (84.3% vs. 76.0%, P = 0.560) or disease-free survival rate (93.8% vs. 74.5%, P = 0.078) between the 2 groups.ConclusionLaparoscopic surgery for splenic flexure colon cancer has better short-term outcomes than open surgery, as well as acceptable long-term outcomes. Laparoscopic surgery can be a safe and feasible alternative to conventional open surgery for splenic flexure colon cancer.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery

et al. 2017

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“…A total of 41 gastrointestinal cancer patients diagnosed with preoperative intestinal and gastric endoscopy underwent curative resection. Various surgical approaches have been used: left and right open hemicolectomy for colon cancer; open anterior resection; total mesorectal excision and open abdominoperineal resection for rectal cancer, and open total gastrectomy with D2 lymph node dissection for gastric cancer [16,17,18,19,20]. Patients were staged according to the 7th edition of the AJCC-TNM classification [13,14,15].…”

Section: Methodsmentioning

confidence: 99%

Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically

et al. 2013

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Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T_3-4N_2a-bM₀ (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T₃N_2-3M₀ (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.

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Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure

Kim

Lee

Yoon

et al. 2018

Robotics Computer Surgery

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Colon Cancer in the Splenic Flexure

Abstract: Laparoscopic surgery for SF cancer is feasible.

Cited by 38 publications

References 17 publications

Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery

Long-term oncologic outcomes of laparoscopic surgery for splenic flexure colon cancer are comparable to conventional open surgery

Mast Cell Positivity to Tryptase Correlates with Metastatic Lymph Nodes in Gastrointestinal Cancer Patients Treated Surgically

Robotic left colectomy with complete mesocolectomy for splenic flexure and descending colon cancer, compared with a laparoscopic procedure

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