Colon Cancer Survival With Herbal Medicine and Vitamins Combined With Standard Therapy in a Whole-Systems Approach

McCulloch, Michael; Broffman, Michael; Laan, Mark van der; Hubbard, Alan; Kushi, Lawrence H.; Abrams, Donald I.; Gao, Jin; Colford, John M.

doi:10.1177/1534735411406539

Cited by 41 publications

(28 citation statements)

References 110 publications

(131 reference statements)

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“…Results indicated that PAM+V combined with conventional therapy, as compared with conventional therapy alone, reduced the risk of patient death at stage I by 95%, stage II by 64%, stage III by 29%, and stage IV by 75%. No significant difference was observed between short-term versus long-term PAM+V administration [118]. This was apparently a sound clinical investigation and suggests that prospective trials combining PAM+V with conventional chemotherapy/radiotherapy may be clinically justifiable in future systematic studies.…”

Section: Use Of Herbal Supplements As Adjuvants In Conventional Anmentioning

confidence: 99%

“…In one study with a 10-year followup of colon cancer patients ( n = 193) who presented to a San Francisco Bay Area Center for Chinese medicine, authors compared the survival rate in patients choosing a short-term treatment regime lasting for the duration of their chemotherapy/radiotherapy period with those choosing a continuing long-term treatment. They also compared the survival of patients treated with Pan-Asian medicine plus vitamins (PAM+V) with that of concurrent external controls from the Kaiser Permanente Northern California and California Cancer Registries [118]. In this study, some modern methods, including Kaplan-Meier and traditional Cox regression, were used for analyses of causal inference, namely, propensity score and marginal structural models (MSMs), which have not been previously used in studies of cancer survival in response to treatment with Chinese herbal medicine.…”

Section: Use Of Herbal Supplements As Adjuvants In Conventional Anmentioning

confidence: 99%

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Therapeutic Applications of Herbal Medicines for Cancer Patients

Yin

Wei

Jian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

276

170

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Medicinal herbs and their derivative phytocompounds are being increasingly recognized as useful complementary treatments for cancer. A large volume of clinical studies have reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics. Here, we briefly review some examples of clinical studies that investigated the use of herbal medicines for various cancers and the development of randomized controlled trials (RCTs) in this emerging research area. In addition, we also report recent studies on the biochemical and cellular mechanisms of herbal medicines in specific tumor microenvironments and the potential application of specific phytochemicals in cell-based cancer vaccine systems. This review should provide useful technological support for evidence-based application of herbal medicines in cancer therapy.

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Section: Use Of Herbal Supplements As Adjuvants In Conventional Anmentioning

confidence: 99%

Section: Use Of Herbal Supplements As Adjuvants In Conventional Anmentioning

confidence: 99%

Therapeutic Applications of Herbal Medicines for Cancer Patients

Yin

Wei

Jian

et al. 2013

Evidence-Based Complementary and Alternative Medicine

276

170

View full text Add to dashboard Cite

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“…13 The use of plants from traditional Chinese medicine (TCM) with conventional chemotherapy is an effective technique to significantly increase the survival of patients with breast cancer, 14 hepatocellular carcinoma, 15 lung carcinoma, 16 and colon cancer. 17 Components of both innate and adaptive immunity are potentially modulated by specific TCMs. 10 In fact, some evidence suggests that plant extracts used in folk medicine induce an antitumor IR.…”

Section: Research-article2015mentioning

confidence: 99%

Multifunctional T Lymphocytes Generated After Therapy With an Antitumor Gallotanin-Rich Normalized Fraction Are Related to Primary Tumor Size Reduction in a Breast Cancer Model

et al. 2015

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Natural compounds are promising sources for anticancer therapies because of their multifunctional activity and low toxicity. Although the host immune response (IR) is clearly implicated in tumor control, the relationship between natural therapies and IR has not yet been elucidated. The present work evaluates IR induction after treatment with a gallotanninrich fraction from Caesalpinia spinosa (P2Et). Breast tumor 4T1 cells were used to evaluate antitumor properties and IR activation. Apoptosis and expression of immunogenic cell death (ICD) markers were assessed in vitro, whereas IR and postvaccination tumor evolution were assessed in vivo. P2Et fraction induced apoptotic cell death, displaying phosphatidylserine externalization and DNA fragmentation. ICD markers such as calreticulin, high-mobility group box 1 translocation from nuclei to cytoplasm, and ATP secretion were observed. Primary tumor control was improved by vaccination with P2Et-pretreated 4T1 cells (t-P2Et), yielding long-lasting ex vivo multifunctional CD4 + and CD8 + T lymphocytes (interleukin [IL]-2 + , tumor necrosis factor [TNF]-α + , interferon [IFN]-γ + ) that secrete IL-2, TNF-α, IL-4, IL-5, and IFN-γ after specific 4T1 cell stimulation. The present study constitutes the first demonstration of a long-lasting antitumor IR induction and primary tumor reduction induced by a complex natural fraction. These data reveal the potential use of this fraction as an adjuvant in breast cancer treatment.

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“…The susceptible population includes the patient suffering from chronic colitis, colon polyps [3] and so on. Nowadays, traditional therapies focus on the surgery and chemo, or Chinese medicine treatment [4]. However, total resection of the lesion is not available yet, patients may suffer recrudescence or tumor metastasis.…”

Section: Introductionmentioning

confidence: 99%

Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression

Wang

Zhang

et al. 2016

Cell Physiol Biochem

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Background/Aims: Paclitaxel (PTX) is one of the most effective anti-cancer drugs. However, multiple drug resistance is still the main factor that hinders the effective treatment of cancer with PTX. Several factors including YAP over-expression can cause PTX resistance. In this study, we aimed to verify the role YAP plays in PTX resistance, explore the reversal of PTX resistance by verteporfin (VP) and investigate the effect of combination therapy of PTX and VP on the PTX resistant colon cancer cells (HCT-8/T). Methods: To study the relationship between YAP and PTX resistance, a stable YAP-over-expression or YAP silencing cell line was generated by transfected with YAP-plasmids or siYAP-RNA. WST-1 assay was performed to detect the cytotoxicity of PTX on HCT-8 and HCT-8/T cells. Clone formation assay and Transwell assay was preformed to determine the cell proliferation and invasion ability respectively. Immunofluorescence and Western blot analysis was performed for protein detection. Results: YAP was stronger expressed in HCT-8/T than in HCT-8, and PTX resistance was positively correlated with the level of YAP expression. VP, a strongly YAP inhibitor, could reduce the PTX resistance on HCT-8/T cells without light activation by inhibiting YAP. Beside, VP and PTX combination therapy showed synergism on inhibition of YAP and cytotoxicity to HCT-8/T. Moreover, verteporfin and PTX combination therapy affect the invasion and colony formation ability and induce apoptosis of HCT-8/T cells. Conclusions: VP can reverse the PTX resistance induced by YAP over-expression in HCT-8/T cells without photoactivation through inhibiting YAP expression.

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Colon Cancer Survival With Herbal Medicine and Vitamins Combined With Standard Therapy in a Whole-Systems Approach

Cited by 41 publications

References 110 publications

Therapeutic Applications of Herbal Medicines for Cancer Patients

Therapeutic Applications of Herbal Medicines for Cancer Patients

Multifunctional T Lymphocytes Generated After Therapy With an Antitumor Gallotanin-Rich Normalized Fraction Are Related to Primary Tumor Size Reduction in a Breast Cancer Model

Verteporfin can Reverse the Paclitaxel Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression

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