Colon Carcinoma Metastasizing to Skin and Breast - Rare Metastasis Sites: A Case Report

Abstract

Colorectal cancer (CRC) is the third most common cancer in the world and second most common cause of cancer mortality after lung cancer. Metastasis to the regional lymph nodes are found in 40-70% of cases at the time of resection, with metastasis to more distant sites occurring most frequently in the liver, peritoneal cavity, and lung, followed by the adrenals, ovaries, and bone. it is a rare case for a CRC to metastasis to skin and breast and that indicates advanced disease. In this case we reported a 64-year-old female CRC patient presenting with cervical and intra abdominal lymph nodes metastase a short time after adjuvant chemotherapy treatment and subsequent developing breast and diffuse skin metastase at initial of new cure chemotherapy. Because of skin and breast metastase related to colorectal cancers are so rare we try to inform this case to literature. Key Words: Colorectal cancer, Breast metastasis, Skin metastasis ÖzKolorektal kanser dünya çapında en sık görülen üçüncü ve akciğer kanserinden sonra en sık ölüme neden olan ikinci malignitedir. Rezeksiyon sırasında hastaların %40-70'inde rejyonel lenf nodu metastazı varken, uzak metastazlar en sık karaciğer, peritoneal kavite ve akciğere, daha nadir olarak da adrenaller, overler ve kemiklere olmaktadır. Bu olguda 64 yaşında kolon kanseri nedeniyle adjuvan kemoterapi alan kadın hastada kısa süre sonra gelişen servikal ve intraabdominal lenf nodu metastazı gelişmesini ve yeni başlanan kemoterapi rejiminden kısa süre sonra meme ve cilt metastazı gelişmesini rapor ettik. Kolorektal kanserlerde meme ve cilt metastazlarının çok nadir olması nedeniyle bu olguyu litaratüre bidirmek istedik. Colorectal cancer the third most common cancer in the world and second most common cause of cancer mortality after lung cancer. The risk for colorectal cancer increases with age, but 3% of colorectal cancers occur in patients younger than 40 years of age. Multiple factors like polyps, diet, inflammatory bowel disease, genetics and smoking drive the transformation of healthy colorectal mucosa to cancer. Genetic and environmental factors, such as maintaining a low body mass index and exercising regularly, correlate with lower incidence rates. Metastases to the regional lymph nodes are found in 40-70 % of cases at the time of resection, with metastases to more distant sites occurring most frequently in the liver, peritoneal cavity, and lung, followed by the adrenals, ovaries, and bone (1). It is a rare case for a CRC to metastasis to skin and breast and that indicates advanced disease. Breast metastasis of CRC is an uncommon case with a poor prognosis. The development of breast metastases is exceptionally rare, account for 0.43 % of all breast malignancies and is associated with poor clinical outcome (2). It is reported that skin