Colon-Specific Prodrugs of 5-Aminosalicylic Acid: Synthesis and In Vitro/In Vivo Properties of Acidic Amino Acid Derivatives of 5-Aminosalicylic Acid

Diglyceride prodrug strategy for enhancing the bioavailability of norfloxacin

“…A new HPLC method was developed for estimation of NFX released from NFXDG in HCl buffer (pH 1.2), phosphate buffer (pH 7.4), stomach and intestinal homogenates (Rainsford, 1975;Morris et al, 1989;Nielson and Bundgaard, 1988;Jung et al, 2001;Scheline, 1973). The HPLC system used for this purpose consisted of a pump (Jasco LC Net II/ADC, Serial No.…”

Drug and Cell Delivery Systems in the Treatment of Colitis

“…Jung et al (1998) formulated stable dextrane conjugate of 5-ASA with delayed release. Lately, they focused their research towards conjugation of 5-ASA with amino acid derivatives where 5-aminosalicyl-L-aspartic acid and 5-aminosalicyl-L-glutamic acid were synthesized and their properties as colon-specific prodrugs of 5-ASA investigated in colitic rats (Jung et al, 2001). The most of 5-ASA-Asp was delivered to the large intestine and about half of the administered dose was activated to liberate 5-ASA.…”

Green and catalyst-free synthesis of olsalazine analogs

“…However, the reported method suffered from low overall yield (15%), long reaction times (82 h), lengthy separation process and column purification of the intermediate compounds (11).…”