Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy

Xu, Chenlan; Chen, Shuting; Chen, Cuiping; Ming, Yangcan; Du, Jiahao; Mu, Jinyi; Luo, Fang; Huang, Da; Wang, Na; Lin, Zhenyu; Weng, Zuquan

doi:10.1016/j.ijpharm.2022.121884

Cited by 41 publications

(32 citation statements)

References 40 publications

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“…When the α-amylase is overexpressed in the inflammatory colon can lead to HES degradation, and the drug is released by amylase reaction from DHC-NPs. Targeting and combination therapy significantly reduce the damage caused by DSS induced UC ( Xu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Medicinal plant-based drug delivery system for inflammatory bowel disease

Wang

Lyu

et al. 2023

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease. The incidence rate of IBD is increasing year by year, which seriously endangers human health worldwide. More and more studies have shown that medicinal plants or their main phytochemicals have great potential in the treatment of intestinal diseases. However, the disadvantages of low oral absorption rate, low biological distribution and low systemic bioavailability limit their clinical application to a certain extent. In recent years, the application of nanotechnology has made it possible to treat IBD. Nanoparticles (NPs) drug delivery system has attracted special attention in the treatment of IBD due to its small size, low immunogenicity, surface modification diversity, targeting and other advantages. Synthetic nanoparticles and extracellular vehicles (EVs) can deliver drug components to colon, and play a role in anti-inflammation, regulation of oxidative stress, improvement of intestinal flora, etc. In addition, some medicinal plants can secrete EVs by themselves, and carry biological molecules with therapeutic effects to act on the intestine. Some clinical trials to evaluate the safety, tolerance, toxicity and effectiveness of EVs-loaded drugs in IBD are also progressing steadily. This review introduces that synthetic nanoparticles and medicinal plants derived EVs can play an important role in the treatment of IBD by carrying the effective active phytochemicals of medicinal plants, and discuss the limitations of current research and future research needs, providing a scientific and reliable basis and perspective for further clinical application and promotion.

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Section: Discussionmentioning

confidence: 99%

Medicinal plant-based drug delivery system for inflammatory bowel disease

Wang

Lyu

et al. 2023

Front. Pharmacol.

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“…8A). 116 Li et al developed an enzyme-triggered controlled release system (CD-Cur-CANPs) using a curcumin-cyclodextrin (CD-Cur) polymer as the core and low molecular weight CS and unsaturated sodium alginate nanoparticles (CANPs) as the shell. In the presence of a-amylase, the enzyme-catalyzed degradation of b-CD causes chain scission within the CD, leading to degradation and release of Cur from CD-Cur-CANPs, achieving targeted drug delivery.…”

Section: Enzyme-responsive Nps Drug Delivery Systemsmentioning

confidence: 99%

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

Hu,

Zhao,

et al. 2024

J. Mater. Chem. B

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“… Hydroxyethyl starch Dexamethasone, ROS scavenger Enhancing the efficacy of APIs with great remission of ulcerative colitis by targeting to the inflamed colon. Inflammatory bowel disease [ 95 ] Inulin Curcumin Improving dissolution and bioavailability of curcumin Intestinal tumor [ 96 ] 4-Aminothiophene-carboxymethyl inulin Budesonide Good therapeutic efficacy for colitis Inflammatory bowel disease [ 88 ] Inulin linked by hydrophobic peptide Ornidazole Providing a colon-targeting drug release Colonic diseases [ 97 ] Levan (fructose-composed biopolymer) Selenium, iron and cobalt Supporting beneficial gut microbiota Malnutrition [ 98 ] Hyaluronic acid Melatonin Improving the dysregulated intestinal barrier, microbiome and immune response Colitis [ 99 ] Chitosan Curcumin Ameliorative anticancer effect of curcumin on colorectal cancer Colorectal cancer [ 100 ] Chitosan Epigallocatechin gallate Enhancing oral absorption and bioavailability of EGCG Local or systemic diseases [ 101 ] Pectin-chitosan Curcumin Increasing the release rate of curcumin in the colon Colon cancer [ 102 ...…”

Section: Nanomedicines Based On P -Ctdds For CD In...mentioning

confidence: 99%

Advancement in Therapeutic Intervention of Prebiotic-Based Nanoparticles for Colonic Diseases

Ren¹,

Nie

Luo³

et al. 2022

IJN

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Intestinal flora has become a therapeutic target for the intervention of colonic diseases (CDs) with better understanding of the interplay between microbiota and CDs. Depending on unique properties and prominent ability of regulating the intestinal flora, prebiotics can not only achieve a colon-specific drug delivery but also maintain the intestinal homeostasis, thus playing a positive role in the intervention of CDs. Currently, different studies on prebiotic-based nanoparticles have been contrived for colonic drug delivery and have shown great potential in curing various CDs, such as colitis and colorectal cancer. Nevertheless, there is a lack of systematic survey on the use of prebiotic nanoparticles for the treatment of CDs. This review aims to generalize the state-of-the-art of prebiotic nanomedicines specific for CDs. The species and function of intestinal flora and various kinds of prebiotics available as well as their regulating effects on intestinal flora were expounded. A variety of prebiotic nanoparticles pertinent to colon-targeted drug delivery systems were illustrated with particular emphasis on their curative activities on CDs. The efficacy and safety of prebiotic-based colonic drug delivery systems ( p -CDDs) were also analyzed. In conclusion, the synergy between prebiotic nanoparticles and their cargos may hold promise for the treatment and intervention of CDs.

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Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy

Cited by 41 publications

References 40 publications

Medicinal plant-based drug delivery system for inflammatory bowel disease

Medicinal plant-based drug delivery system for inflammatory bowel disease

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

Advancement in Therapeutic Intervention of Prebiotic-Based Nanoparticles for Colonic Diseases

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